IL133493A0 - Intermediates for the preparation of synthetic excitatory amino acids - Google Patents

Intermediates for the preparation of synthetic excitatory amino acids

Info

Publication number
IL133493A0
IL133493A0 IL13349399A IL13349399A IL133493A0 IL 133493 A0 IL133493 A0 IL 133493A0 IL 13349399 A IL13349399 A IL 13349399A IL 13349399 A IL13349399 A IL 13349399A IL 133493 A0 IL133493 A0 IL 133493A0
Authority
IL
Israel
Prior art keywords
intermediates
preparation
amino acids
excitatory amino
synthetic excitatory
Prior art date
Application number
IL13349399A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/496,643 external-priority patent/US5750566A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL133493A0 publication Critical patent/IL133493A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL13349399A 1994-08-12 1999-12-13 Intermediates for the preparation of synthetic excitatory amino acids IL133493A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28995794A 1994-08-12 1994-08-12
US33734994A 1994-11-10 1994-11-10
US08/496,643 US5750566A (en) 1994-08-12 1995-06-29 Synthetic excitatory amino acids

Publications (1)

Publication Number Publication Date
IL133493A0 true IL133493A0 (en) 2001-04-30

Family

ID=27403949

Family Applications (2)

Application Number Title Priority Date Filing Date
IL11491095A IL114910A (en) 1994-08-12 1995-08-11 Synthetic excitatory amino acids their preparation and pharmaceutical compositions containing them
IL13349399A IL133493A0 (en) 1994-08-12 1999-12-13 Intermediates for the preparation of synthetic excitatory amino acids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL11491095A IL114910A (en) 1994-08-12 1995-08-11 Synthetic excitatory amino acids their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (2) US5925782A (xx)
EP (1) EP0696577B1 (xx)
JP (1) JP2883297B2 (xx)
CN (1) CN1066135C (xx)
AP (1) AP758A (xx)
AT (1) ATE172186T1 (xx)
AU (2) AU692276B2 (xx)
BG (1) BG62728B1 (xx)
CA (1) CA2156024C (xx)
CZ (1) CZ291270B6 (xx)
DE (1) DE69505318T2 (xx)
DK (1) DK0696577T3 (xx)
ES (1) ES2122456T3 (xx)
FI (1) FI114861B (xx)
HK (1) HK1013983A1 (xx)
HU (1) HU223845B1 (xx)
IL (2) IL114910A (xx)
MY (1) MY115977A (xx)
NO (1) NO306342B1 (xx)
NZ (1) NZ272772A (xx)
PL (1) PL182285B1 (xx)
RO (1) RO119147B1 (xx)
SK (1) SK281288B6 (xx)
TW (1) TW438741B (xx)
WO (1) WO1996005175A1 (xx)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118727A (en) * 1995-06-29 2003-01-12 Lilly Co Eli (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid
KR19990067598A (ko) * 1995-11-16 1999-08-25 피터 지. 스트링거 여기성 아미노산 유도체
US5912248A (en) * 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
ZA969485B (en) * 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
GB9605429D0 (en) * 1995-11-16 1996-05-15 Lilly Co Eli Excitatory amino acid receptor antagonists
BR9611521A (pt) 1995-11-16 1999-06-29 Lilly Co Eli Antagonistas de receptor de aminoácido excitador
US5688826A (en) * 1995-11-16 1997-11-18 Eli Lilly And Company Excitatory amino acid derivatives
US5824662A (en) * 1996-09-27 1998-10-20 Guilford Pharmaceuticals Inc. Treatment of global and focal ischemia using naaladase inhibitors
US6017903A (en) 1996-09-27 2000-01-25 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
WO1998013046A1 (en) 1996-09-27 1998-04-02 Guilford Pharmaceuticals Inc. Naaladase compositions and methods for treating glutamate abnormality and effecting neuronal activity in animals
WO1998032436A1 (en) * 1997-01-29 1998-07-30 Eli Lilly And Company Treatment for premenstrual dysphoric disorder
ZA983930B (en) 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
ES2172840T3 (es) * 1997-07-18 2002-10-01 Hoffmann La Roche Derivados de 5h-tiazolo(3,2-a)pirimidina.
US6825211B1 (en) 1997-07-18 2004-11-30 Georgetown University Bicyclic metabotropic glutamate receptor ligands
US6204292B1 (en) 1997-07-18 2001-03-20 Georgetown University Bicyclic metabotropic glutamate receptor ligands
JP3727791B2 (ja) * 1998-01-08 2005-12-14 ファイザー・プロダクツ・インク 二環式［３．１．０］ヘキサン及び関連化合物
ES2191412T3 (es) 1998-01-28 2003-09-01 Taisho Pharmaceutical Co Ltd Derivados de aminoacidos que contienen fluor.
US5933378A (en) * 1998-02-26 1999-08-03 Micron Technology, Inc. Integrated circuit having forced substrate test mode with improved substrate isolation
CA2321639C (en) * 1998-03-17 2005-08-02 Pfizer Products Inc. Bicyclo[2.2.1]heptanes and related compounds
SI1064256T1 (en) * 1998-03-17 2004-10-31 Pfizer Products Inc. Bicyclo (2.2.1) heptanes and related compounds
GB9815542D0 (en) * 1998-07-17 1998-09-16 Lilly Co Eli Bicyclohexane derivatives
KR100469182B1 (ko) 1998-08-31 2005-02-02 다이쇼 세이야꾸 가부시끼가이샤 6-플루오로비시클로[3.1.0]헥산 유도체
CH694053A5 (de) * 1998-09-03 2004-06-30 Hoffmann La Roche Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
JP4192331B2 (ja) 1999-04-16 2008-12-10 住友化学株式会社 光学活性２−オキソビシクロ［３．１．０］ヘキサン−６−カルボン酸誘導体の製造方法
JP4783967B2 (ja) * 1999-07-21 2011-09-28 大正製薬株式会社 含フッ素アミノ酸誘導体を有効成分とする医薬
GB2355982A (en) * 1999-11-03 2001-05-09 Lilly Co Eli Heterocyclic amino acids
EP1351925A1 (en) 2001-01-11 2003-10-15 Eli Lilly And Company Prodrugs of excitatory amino acids
US7256217B2 (en) * 2001-01-11 2007-08-14 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1310480A1 (en) * 2001-11-07 2003-05-14 Eli Lilly & Company Prodrugs of excitatory amino acids
WO2003045898A1 (en) * 2001-11-23 2003-06-05 Eli Lilly And Company Prodrugs of excitatory amino acids
US7456221B2 (en) 2001-12-21 2008-11-25 Eli Lilly And Company Prodrugs of excitatory amino acids
EP1458671A1 (en) * 2001-12-21 2004-09-22 Eli Lilly And Company Prodrugs of excitatory amino acids
US20040116489A1 (en) * 2002-02-12 2004-06-17 Massey Steven Marc Synthetic excitatory amino acids
US7795266B2 (en) * 2003-09-25 2010-09-14 Helton David R Tetrahydroindolone derivatives for treament of neurological conditions
US20050107439A1 (en) * 2003-11-10 2005-05-19 Helton David R. Composition and method for treating emesis
EP2219648A4 (en) * 2007-11-09 2010-11-03 Cenomed Biosciences Llc TREATMENT OF POSTRAUMATIC STRESS WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS
US20090264443A1 (en) * 2008-04-18 2009-10-22 David Helton Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds
WO2010111080A2 (en) 2009-03-27 2010-09-30 Eli Lilly And Company Optimized treatment of schizophrenia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3704312A (en) * 1970-10-30 1972-11-28 American Home Prod Bialicyclic amino acids
US3746495A (en) * 1971-06-01 1973-07-17 American Home Prod Anti-ulcer therapy
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds
US5661184A (en) * 1994-08-12 1997-08-26 Eli Lilly And Company Psychiatric agents

Also Published As

Publication number Publication date
ES2122456T3 (es) 1998-12-16
IL114910A (en) 2000-06-29
NO306342B1 (no) 1999-10-25
CN1123272A (zh) 1996-05-29
EP0696577B1 (en) 1998-10-14
SK13397A3 (en) 1997-07-09
CA2156024A1 (en) 1996-02-13
PL309972A1 (en) 1996-02-19
NO953191L (no) 1996-02-13
US5925680A (en) 1999-07-20
HK1013983A1 (en) 1999-09-17
CA2156024C (en) 2004-10-05
US5925782A (en) 1999-07-20
HU223845B1 (hu) 2005-02-28
DE69505318T2 (de) 1999-03-25
FI953837A0 (fi) 1995-08-14
BG62728B1 (bg) 2000-06-30
NO953191D0 (no) 1995-08-14
RO119147B1 (ro) 2004-04-30
NZ272772A (en) 1997-10-24
AP758A (en) 1999-09-10
FI114861B (fi) 2005-01-14
TW438741B (en) 2001-06-07
AU3325195A (en) 1996-03-07
AU2853095A (en) 1996-02-22
PL182285B1 (pl) 2001-12-31
ATE172186T1 (de) 1998-10-15
CN1066135C (zh) 2001-05-23
BG101213A (en) 1998-03-31
EP0696577A1 (en) 1996-02-14
WO1996005175A1 (en) 1996-02-22
HU9502380D0 (en) 1996-05-28
CZ207495A3 (en) 1996-05-15
JP2883297B2 (ja) 1999-04-19
AU692276B2 (en) 1998-06-04
JPH08188561A (ja) 1996-07-23
FI953837A (fi) 1996-02-13
HUT75524A (en) 1997-05-28
DK0696577T3 (da) 1999-06-23
CZ291270B6 (cs) 2003-01-15
AP9700922A0 (en) 1997-01-31
IL114910A0 (en) 1995-12-08
DE69505318D1 (de) 1998-11-19
MY115977A (en) 2003-10-31
SK281288B6 (sk) 2001-02-12

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Legal Events

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FF Patent granted
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