IL132077A0 - Process for producing 1-chlorocarbonyl-4- piperidinopiperidine or hydrochloride thereof - Google Patents

Process for producing 1-chlorocarbonyl-4- piperidinopiperidine or hydrochloride thereof

Info

Publication number
IL132077A0
IL132077A0 IL13207798A IL13207798A IL132077A0 IL 132077 A0 IL132077 A0 IL 132077A0 IL 13207798 A IL13207798 A IL 13207798A IL 13207798 A IL13207798 A IL 13207798A IL 132077 A0 IL132077 A0 IL 132077A0
Authority
IL
Israel
Prior art keywords
piperidinopiperidine
hydrochloride
chlorocarbonyl
producing
trialkylsilyl
Prior art date
Application number
IL13207798A
Other versions
IL132077A (en
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Publication of IL132077A0 publication Critical patent/IL132077A0/en
Publication of IL132077A publication Critical patent/IL132077A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention provides a highly safe and easily operable process for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof in a high yield. Described specifically, the present invention relates to a process for producing 1-clorocarbonyl-4-piperidinopiperidine or hydrochloride thereof, which comprises reacting 4-piperidinopiperidine with a trialkylsilyl halide to obtain a 4-piperidinopiperidinyl trialkylsilyl, reacting it with a carbon dioxide gas to obtain a 4-piperidinopiperidinyl trialkylsilyl carbamate derivative, reacting the derivative with thionyl chloride or the like to obtain 1-chlorocarbonyl-4-piperidinopiperidine hydrochloride and optionally treating it with a strong base.
IL13207798A 1997-04-11 1998-03-31 Process for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof IL132077A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9093723A JP3046258B2 (en) 1997-04-11 1997-04-11 Method for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof
PCT/JP1998/001465 WO1998046568A1 (en) 1997-04-11 1998-03-31 Process for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof

Publications (2)

Publication Number Publication Date
IL132077A0 true IL132077A0 (en) 2001-03-19
IL132077A IL132077A (en) 2002-11-10

Family

ID=14090343

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13207798A IL132077A (en) 1997-04-11 1998-03-31 Process for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof

Country Status (16)

Country Link
US (1) US6147215A (en)
EP (1) EP0976733B1 (en)
JP (1) JP3046258B2 (en)
CN (1) CN1110479C (en)
AT (1) ATE232517T1 (en)
AU (1) AU723133B2 (en)
BR (1) BR9808105B1 (en)
CA (1) CA2286914C (en)
DE (1) DE69811358T2 (en)
DK (1) DK0976733T3 (en)
EA (1) EA001696B1 (en)
ES (1) ES2192765T3 (en)
IL (1) IL132077A (en)
TW (1) TW419476B (en)
WO (1) WO1998046568A1 (en)
ZA (1) ZA982960B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5133703B2 (en) * 2005-02-08 2013-01-30 フェルミオン オサケ ユキチュア [1,4 '] bipiperidinyl-1'-carbonyl chloride or a method for producing the hydrochloride thereof
US8546573B2 (en) * 2009-11-18 2013-10-01 Cadila Healthcare Limited Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperdino] carbonyloxy-camptothecin hydrochloride trihydrate
CN102869747B (en) 2009-12-30 2017-06-30 普拉德研究及开发股份有限公司 The method of the fluid slug consolidation within fluid system in down-hole application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5540754A (en) * 1978-09-19 1980-03-22 Mitsubishi Electric Corp Electrodeposition coating
JPS6019790A (en) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd Novel camptothecin derivative
JPS6150984A (en) * 1984-07-05 1986-03-13 Yakult Honsha Co Ltd Novel camptothecin derivative
WO1992007856A1 (en) * 1990-10-31 1992-05-14 Smithkline Beecham Corporation SUBSTITUTED INDOLIZINO[1,2-b]QUINOLINONES

Also Published As

Publication number Publication date
EP0976733A4 (en) 2001-05-09
IL132077A (en) 2002-11-10
DE69811358T2 (en) 2003-10-16
US6147215A (en) 2000-11-14
CN1110479C (en) 2003-06-04
CA2286914A1 (en) 1998-10-22
EA199900926A1 (en) 2000-04-24
DE69811358D1 (en) 2003-03-20
EA001696B1 (en) 2001-06-25
AU6520698A (en) 1998-11-11
ZA982960B (en) 1998-10-09
JP3046258B2 (en) 2000-05-29
AU723133B2 (en) 2000-08-17
CN1252055A (en) 2000-05-03
EP0976733A1 (en) 2000-02-02
EP0976733B1 (en) 2003-02-12
JPH10287650A (en) 1998-10-27
ES2192765T3 (en) 2003-10-16
BR9808105B1 (en) 2008-11-18
WO1998046568A1 (en) 1998-10-22
CA2286914C (en) 2005-07-26
TW419476B (en) 2001-01-21
DK0976733T3 (en) 2003-03-31
BR9808105A (en) 2000-03-08
ATE232517T1 (en) 2003-02-15

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Legal Events

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