IL129604A0 - Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents - Google Patents

Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents

Info

Publication number: IL129604A0
Authority: IL; Israel
Prior art keywords: cyclooxygenase; inhibitors; angiogenic agents; angiogenic; agents
Prior art date: 1996-11-19

Application number

IL12960497A

Other versions

IL129604A (en

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-19

Filing date

1997-11-19

Publication date

2000-02-29

1997-11-19 Application filed by Searle & Co filed Critical Searle & Co

1997-11-19 Priority to IL15450297A priority Critical patent/IL154502A/en

2000-02-29 Publication of IL129604A0 publication Critical patent/IL129604A0/en

2004-08-31 Publication of IL129604A publication Critical patent/IL129604A/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Reproductive Health (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL12960497A 1996-11-19 1997-11-19 Use of cyclooxygenase-2 inhibitors for the treatment and prevention of angiogenic-related disorders IL129604A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL15450297A IL154502A (en)	1996-11-19	1997-11-19	Use of cyclooxygenase-2 inhibitors in the preparation of medicaments for treating angiogenesis-related disorders

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3140496P	1996-11-19	1996-11-19
PCT/US1997/021489 WO1998022101A2 (en)	1996-11-19	1997-11-19	Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents

Publications (2)

Publication Number	Publication Date
IL129604A0 true IL129604A0 (en)	2000-02-29
IL129604A IL129604A (en)	2004-08-31

Family

ID=21859277

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12960497A IL129604A (en)	1996-11-19	1997-11-19	Use of cyclooxygenase-2 inhibitors for the treatment and prevention of angiogenic-related disorders

Country Status (19)

Country	Link
EP (1)	EP0941080A2 (en)
JP (1)	JP2001505564A (en)
KR (1)	KR20000053362A (en)
CN (1)	CN1247470A (en)
AU (1)	AU730211B2 (en)
BR (1)	BR9713522A (en)
CA (1)	CA2270469C (en)
CZ (1)	CZ176899A3 (en)
ID (1)	ID21979A (en)
IL (1)	IL129604A (en)
NO (1)	NO992309L (en)
NZ (1)	NZ335853A (en)
PL (2)	PL194717B1 (en)
RO (1)	RO118566B1 (en)
RU (1)	RU2268716C2 (en)
SK (1)	SK59999A3 (en)
TR (1)	TR199901703T2 (en)
UA (1)	UA70294C2 (en)
WO (1)	WO1998022101A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6512121B2 (en)	1998-09-14	2003-01-28	G.D. Searle & Co.	Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US6515014B2 (en)	1995-06-02	2003-02-04	G. D. Searle & Co.	Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
NZ333399A (en)	1997-12-24	2000-05-26	Sankyo Co	Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
BR9916536A (en) *	1998-12-23	2002-01-02	Searle & Co	Method for treating or preventing a neoplasm disorder in a mammal in need of such treatment or prevention, and, combination
US20030013739A1 (en) *	1998-12-23	2003-01-16	Pharmacia Corporation	Methods of using a combination of cyclooxygenase-2 selective inhibitors and thalidomide for the treatment of neoplasia
EP1158977B1 (en) *	1999-03-10	2005-10-12	G.D. Searle LLC	Composition for administering a cyclooxygenase-2 inhibitor to animals
WO2001008693A2 (en) *	1999-07-29	2001-02-08	Tularik Inc.	Combination therapy using pentafluorobenzenesulfonamide and platin compound
EP1282418B1 (en) *	2000-05-19	2005-08-17	Applied Research Systems ARS Holding N.V.	Use of pyrazole derivatives for treating infertility
US6822001B2 (en)	2000-11-03	2004-11-23	Tularik Inc.	Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
KR100686537B1 (en) *	2001-12-28	2007-02-27	씨제이 주식회사	Diaryl 1,2,4-triazole derivatives as a highly selective cyclooxygenase-2 inhibitor
WO2004006931A2 (en) *	2002-07-17	2004-01-22	Warner-Lambert Company Llc	Pharmaceutical compostions comprising an allosteric carboxylic inhibitor of matrix metalloproteinase-13 and a selective inhibitor of cyclooxygenase-2
KR100484525B1 (en) *	2002-10-15	2005-04-20	씨제이 주식회사	Isothiazole derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same
AT504159A1 (en) *	2006-08-16	2008-03-15	Marlyn Nutraceuticals Inc	USE OF PROTEASES
RU2475257C1 (en) *	2011-06-22	2013-02-20	Людмила Николаевна Третьяк	Preparation for increasing organism adaptability to extreme conditions
GB2496135B (en) *	2011-11-01	2015-03-18	Valirx Plc	Inhibitors of the interaction between a Src family kinase and an androgen receptor or estradiol receptor for treatment of endometriosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE160345T1 (en) *	1993-01-15	1997-12-15	Searle & Co	3,4-DIARYLTHIOPHENES AND ANALOGS THEREOF AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
US5436265A (en) *	1993-11-12	1995-07-25	Merck Frosst Canada, Inc.	1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
ES2193609T3 (en) *	1993-11-30	2003-11-01	Searle & Co	PIRAZOLIL-BENCENOSULFONAMIDAS SUBSTITUTED AND ITS USE AS INHIBITORS OF CYCLOOXYGENASE II.
US5521213A (en) *	1994-08-29	1996-05-28	Merck Frosst Canada, Inc.	Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
ES2191069T3 (en) *	1994-12-21	2003-09-01	Merck Frosst Canada Inc	DIARIL-2- (5H) -FURANONAS AS COX-2 INHIBITORS.
US5691374A (en) *	1995-05-18	1997-11-25	Merck Frosst Canada Inc.	Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors

1997
- 1997-11-19 TR TR1999/01703T patent/TR199901703T2/en unknown
- 1997-11-19 AU AU72982/98A patent/AU730211B2/en not_active Ceased
- 1997-11-19 JP JP52396098A patent/JP2001505564A/en not_active Withdrawn
- 1997-11-19 IL IL12960497A patent/IL129604A/en not_active IP Right Cessation
- 1997-11-19 SK SK599-99A patent/SK59999A3/en unknown
- 1997-11-19 CA CA002270469A patent/CA2270469C/en not_active Expired - Fee Related
- 1997-11-19 BR BR9713522A patent/BR9713522A/en not_active Application Discontinuation
- 1997-11-19 ID IDW990379A patent/ID21979A/en unknown
- 1997-11-19 EP EP97949579A patent/EP0941080A2/en not_active Withdrawn
- 1997-11-19 RO RO99-00572A patent/RO118566B1/en unknown
- 1997-11-19 PL PL97373973A patent/PL194717B1/en unknown
- 1997-11-19 RU RU99112952/14A patent/RU2268716C2/en not_active IP Right Cessation
- 1997-11-19 KR KR1019990704392A patent/KR20000053362A/en not_active Application Discontinuation
- 1997-11-19 UA UA99063447A patent/UA70294C2/en unknown
- 1997-11-19 CN CN97181368A patent/CN1247470A/en active Pending
- 1997-11-19 CZ CZ991768A patent/CZ176899A3/en unknown
- 1997-11-19 WO PCT/US1997/021489 patent/WO1998022101A2/en not_active Application Discontinuation
- 1997-11-19 NZ NZ335853A patent/NZ335853A/en not_active Application Discontinuation
1999
- 1999-04-30 PL PL333370A patent/PL191793B1/en unknown
- 1999-05-12 NO NO992309A patent/NO992309L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
PL191793B1 (en)	2006-07-31
NZ335853A (en)	2002-02-01
BR9713522A (en)	2000-03-21
NO992309D0 (en)	1999-05-12
CA2270469C (en)	2007-04-10
AU7298298A (en)	1998-06-10
CZ176899A3 (en)	1999-10-13
UA70294C2 (en)	2004-10-15
IL129604A (en)	2004-08-31
NO992309L (en)	1999-05-12
KR20000053362A (en)	2000-08-25
JP2001505564A (en)	2001-04-24
RU2268716C2 (en)	2006-01-27
TR199901703T2 (en)	2000-07-21
CA2270469A1 (en)	1998-05-28
SK59999A3 (en)	2000-01-18
EP0941080A2 (en)	1999-09-15
ID21979A (en)	1999-08-19
AU730211B2 (en)	2001-03-01
RO118566B1 (en)	2003-07-30
WO1998022101A3 (en)	1998-06-25
PL194717B1 (en)	2007-06-29
WO1998022101A2 (en)	1998-05-28
CN1247470A (en)	2000-03-15
PL333370A1 (en)	1999-12-06

Legal Events

Date	Code	Title
2005-01-24	FF	Patent granted
2005-02-20	KB	Patent renewed
2008-01-06	KB	Patent renewed
2012-10-31	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
PL330995A1 (en)	1999-06-21	Substituted pyridines as selective inhibitors of cyclooxygenase-2
PL327569A1 (en)	1998-12-21	Promedications of thrombosin inhibitors
ZA983249B (en)	1999-04-19	Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders
PL334846A1 (en)	2000-03-27	Sulphamidic inhibitors of metaloproteases
PL331856A1 (en)	1999-08-16	Heterocyclic inhibitors of metaloprotease
IL129604A0 (en)	2000-02-29	Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
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IL154502A0 (en)	2003-09-17	Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
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