IL125889A0 - Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide - Google Patents
Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxideInfo
- Publication number
- IL125889A0 IL125889A0 IL12588997A IL12588997A IL125889A0 IL 125889 A0 IL125889 A0 IL 125889A0 IL 12588997 A IL12588997 A IL 12588997A IL 12588997 A IL12588997 A IL 12588997A IL 125889 A0 IL125889 A0 IL 125889A0
- Authority
- IL
- Israel
- Prior art keywords
- bioconjugates
- catalysts
- manganese
- nitrogen
- iron complexes
- Prior art date
Links
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 title 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 title 1
- 239000003054 catalyst Substances 0.000 title 1
- 150000002505 iron Chemical class 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 229910052748 manganese Inorganic materials 0.000 title 1
- 239000011572 manganese Substances 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1334896P | 1996-03-13 | 1996-03-13 | |
PCT/US1996/012767 WO1997006824A2 (en) | 1995-08-17 | 1996-08-14 | Bioconjugates of manganese complexes and their application as catalysts |
PCT/US1997/002566 WO1997033877A1 (en) | 1996-03-13 | 1997-03-04 | Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
Publications (1)
Publication Number | Publication Date |
---|---|
IL125889A0 true IL125889A0 (en) | 1999-04-11 |
Family
ID=21759507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12588997A IL125889A0 (en) | 1996-03-13 | 1997-03-04 | Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0891338A1 (en) |
JP (1) | JP2000508625A (en) |
KR (1) | KR19990087784A (en) |
CN (1) | CN1225631A (en) |
AU (1) | AU1962497A (en) |
BR (1) | BR9708179A (en) |
CA (1) | CA2249011A1 (en) |
CZ (1) | CZ271198A3 (en) |
IL (1) | IL125889A0 (en) |
NO (1) | NO984164L (en) |
WO (1) | WO1997033877A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6180620B1 (en) | 1997-06-20 | 2001-01-30 | G.D. Searle & Co. | Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals |
US6214817B1 (en) * | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
EP1155019B1 (en) | 1999-01-25 | 2005-12-07 | National Jewish Medical and Research Center | Substituted porphyrins and their therapeutic use |
WO2000054784A1 (en) * | 1999-03-15 | 2000-09-21 | Abdurafik Bakhramovich Akbarov | Complex comprising the coordination compound manganese, its medical effects and the mode of its production |
ATE383364T1 (en) * | 1999-05-27 | 2008-01-15 | Monsanto Co | BIOMATERIALS MODIFIED WITH SUPEROXIDE DISMUTASE MIMITATORS |
US20050176790A1 (en) | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
JP2005508864A (en) | 2001-06-01 | 2005-04-07 | ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター | Oxidant scavengers for the treatment of diabetes or for use in transplantation or for induction of immune tolerance |
CN102088991A (en) | 2008-05-13 | 2011-06-08 | 堪萨斯大学 | Metal abstraction peptide (MAP) tag and associated methods |
CA2725012C (en) | 2008-05-23 | 2019-05-07 | National Jewish Health | Methods for treating injury associated with exposure to an alkylating species |
WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0598753B1 (en) * | 1991-07-19 | 1998-03-18 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
IL104059A0 (en) * | 1991-12-10 | 1993-05-13 | Dow Chemical Co | Bicyclopolyazamacrocyclocarboxylic acid complexes,their conjugates,processes for their preparation,and use as contrast agents |
US5747026A (en) * | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
WO1996039409A1 (en) * | 1995-06-05 | 1996-12-12 | Nitromed, Inc. | Nitrosylated and nitrated superoxide oxidants and reductants |
US6525041B1 (en) * | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
JPH11507621A (en) * | 1995-06-07 | 1999-07-06 | モンサント カンパニー | Process for producing substituted polyaza macrocycles |
-
1997
- 1997-03-04 CZ CZ982711A patent/CZ271198A3/en unknown
- 1997-03-04 IL IL12588997A patent/IL125889A0/en unknown
- 1997-03-04 WO PCT/US1997/002566 patent/WO1997033877A1/en not_active Application Discontinuation
- 1997-03-04 JP JP9532611A patent/JP2000508625A/en active Pending
- 1997-03-04 BR BR9708179A patent/BR9708179A/en not_active Application Discontinuation
- 1997-03-04 CA CA002249011A patent/CA2249011A1/en not_active Abandoned
- 1997-03-04 AU AU19624/97A patent/AU1962497A/en not_active Abandoned
- 1997-03-04 KR KR1019980707265A patent/KR19990087784A/en not_active Application Discontinuation
- 1997-03-04 CN CN97194351A patent/CN1225631A/en active Pending
- 1997-03-04 EP EP97907685A patent/EP0891338A1/en not_active Withdrawn
-
1998
- 1998-09-10 NO NO984164A patent/NO984164L/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR9708179A (en) | 1999-07-27 |
AU1962497A (en) | 1997-10-01 |
WO1997033877A1 (en) | 1997-09-18 |
CA2249011A1 (en) | 1997-09-18 |
NO984164L (en) | 1998-11-06 |
KR19990087784A (en) | 1999-12-27 |
NO984164D0 (en) | 1998-09-10 |
CZ271198A3 (en) | 1999-01-13 |
JP2000508625A (en) | 2000-07-11 |
EP0891338A1 (en) | 1999-01-20 |
CN1225631A (en) | 1999-08-11 |
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