IL125884A0 - Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes - Google Patents

Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes

Info

Publication number
IL125884A0
IL125884A0 IL12588497A IL12588497A IL125884A0 IL 125884 A0 IL125884 A0 IL 125884A0 IL 12588497 A IL12588497 A IL 12588497A IL 12588497 A IL12588497 A IL 12588497A IL 125884 A0 IL125884 A0 IL 125884A0
Authority
IL
Israel
Prior art keywords
modified
rem
lymphocytes
rapid expansion
expansion methods
Prior art date
Application number
IL12588497A
Original Assignee
Targeted Genetics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targeted Genetics Corp filed Critical Targeted Genetics Corp
Publication of IL125884A0 publication Critical patent/IL125884A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL12588497A 1996-03-04 1997-03-03 Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes IL125884A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61071096A 1996-03-04 1996-03-04
PCT/US1997/003293 WO1997032970A1 (en) 1996-03-04 1997-03-03 Modified rapid expansion methods ('modified-rem') for in vitro propagation of t lymphocytes

Publications (1)

Publication Number Publication Date
IL125884A0 true IL125884A0 (en) 1999-04-11

Family

ID=24446115

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12588497A IL125884A0 (en) 1996-03-04 1997-03-03 Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes

Country Status (4)

Country Link
AU (1) AU726198B2 (en)
CA (1) CA2247131A1 (en)
IL (1) IL125884A0 (en)
WO (1) WO1997032970A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4389039B2 (en) * 1998-04-09 2009-12-24 株式会社リンフォテック PHARMACEUTICAL COMPOSITION CONTAINING ALLOGENIC ACTIVATED CD4-POSITIVE CELLS AS MAIN COMPONENTS, PROCESS FOR PRODUCING THE SAME AND KIT FOR PREPARING THE PHARMACEUTICAL COMPOSITION
CN1222612C (en) 2000-08-16 2005-10-12 宝生物工程株式会社 Method of extensive culture of antigen-specific cytotoxic T cells
US20040071671A1 (en) 2001-02-20 2004-04-15 Leturcq Didier J. Cell therapy method for the treatment of tumors
US20030077248A1 (en) * 2001-02-20 2003-04-24 Ann Moriarty Cell therapy method for the treatment of tumors
DE10120505A1 (en) * 2001-04-26 2002-11-07 Rudolf Wank Use of stimulated peripheral blood mononuclear cells for the treatment of cancer
JP4949607B2 (en) * 2001-08-15 2012-06-13 タカラバイオ株式会社 Antigen-specific cytotoxic T cell expansion culture method
CN100591760C (en) 2002-03-25 2010-02-24 宝生物工程株式会社 Process for producing cytotoxic lymphocyte
JP4562353B2 (en) * 2002-04-08 2010-10-13 株式会社リンフォテック Formulation for prevention / treatment of tumors / infections and autoimmune diseases comprising activated lymphocytes derived from HLA-matched others
US20050084967A1 (en) 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
EP3427741A3 (en) 2003-02-28 2019-02-13 The Johns Hopkins University T cell regulation
EA012520B1 (en) 2003-08-22 2009-10-30 Такара Био Инк. Process for producing cytotoxic lymphocytes
EP1916302A4 (en) 2005-08-17 2009-10-21 Takara Bio Inc Method of producing lymphocytes
KR20090024782A (en) 2006-06-09 2009-03-09 다카라 바이오 가부시키가이샤 Method of producing lymphocytes
WO2008153742A2 (en) * 2007-05-23 2008-12-18 Sangamo Biosciences, Inc. Methods and compositions for increased transgene expression
WO2013094988A1 (en) * 2011-12-22 2013-06-27 Mogam Biotechnology Research Institute Method for producing natural killer cells, natural killer cells produced thereby, and composition for treating cancers and infectious diseases containing the same
US9907820B2 (en) 2013-10-25 2018-03-06 Board Of Regents, The University Of Texas System Polyclonal gamma delta T cells for immunotherapy
NZ725201A (en) * 2014-04-25 2018-05-25 Bluebird Bio Inc Improved methods for manufacturing adoptive cell therapies
IL296691B2 (en) 2014-04-25 2023-11-01 2Seventy Bio Inc Mnd promoter chimeric antigen receptors
RS61406B1 (en) 2014-06-06 2021-03-31 Bluebird Bio Inc Improved t cell compositions
EP3172231B1 (en) 2014-07-24 2021-05-05 Bluebird Bio, Inc. Bcma chimeric antigen receptors
KR101697473B1 (en) 2014-11-26 2017-01-18 주식회사 녹십자랩셀 Method for Preparation of Natural Killer Cells Using T Cells
EP3640262A1 (en) 2014-12-12 2020-04-22 Bluebird Bio, Inc. Bcma chimeric antigen receptors for use in the treatment of a hematological malignancy
US11479755B2 (en) 2015-12-07 2022-10-25 2Seventy Bio, Inc. T cell compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007077A1 (en) * 1987-03-11 1988-09-22 The Children's Hospital, Incorporated Method for the generation of antigen-specific t cell lines and therapeutic use thereof
US5057423A (en) 1987-12-18 1991-10-15 University Of Pittsburgh Method for the preparation of pure LAK-active lymphocytes
ZA91463B (en) * 1990-01-25 1992-09-30 Bristol Myers Squibb Co Method of activating cytolytic activity of lymphocytes using anti-cd28 antibody
JPH06503719A (en) * 1990-09-28 1994-04-28 イムネクス　コーポレイション Method for producing T↓h-dependent cytotoxic T lymphocytes
IE913929A1 (en) * 1990-11-13 1992-05-20 Immunex Corp Bifunctional selectable fusion genes
DE4410136A1 (en) * 1993-03-31 1994-10-06 Boehringer Mannheim Gmbh Tumoricidal T lymphocytes
US5827642A (en) * 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes

Also Published As

Publication number Publication date
CA2247131A1 (en) 1997-09-12
AU726198B2 (en) 2000-11-02
WO1997032970A1 (en) 1997-09-12
AU2194797A (en) 1997-09-22

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