IL123638A - Micromolecules for use as carriers for the release of active compounds - Google Patents

Micromolecules for use as carriers for the release of active compounds

Info

Publication number: IL123638A
Authority: IL; Israel
Prior art keywords: microemulsion; water; microemulsion according; surfactant; polar phase
Prior art date: 1995-09-12

Application number

IL12363896A

Other languages

English (en)

Hebrew (he)

Other versions

IL123638A0 (en

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-12

Filing date

1996-09-04

Publication date

2004-06-20

1996-09-04 Application filed by Astra Ab filed Critical Astra Ab

1998-10-30 Publication of IL123638A0 publication Critical patent/IL123638A0/xx

2004-06-20 Publication of IL123638A publication Critical patent/IL123638A/en

Links

239000004530 micro-emulsion Substances 0.000 title claims abstract description 62
150000001875 compounds Chemical class 0.000 title claims abstract description 28
239000004094 surface-active agent Substances 0.000 claims abstract description 44
239000000203 mixture Substances 0.000 claims abstract description 42
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 31
239000003981 vehicle Substances 0.000 claims abstract description 20
239000003607 modifier Substances 0.000 claims abstract description 18
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 17
150000002632 lipids Chemical class 0.000 claims abstract description 8
230000002209 hydrophobic effect Effects 0.000 claims abstract description 7
231100000252 nontoxic Toxicity 0.000 claims abstract description 7
230000003000 nontoxic effect Effects 0.000 claims abstract description 7
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 5
239000003795 chemical substances by application Substances 0.000 claims abstract description 5
239000000787 lecithin Substances 0.000 claims abstract description 5
229940067606 lecithin Drugs 0.000 claims abstract description 5
235000010445 lecithin Nutrition 0.000 claims abstract description 5
150000003408 sphingolipids Chemical class 0.000 claims abstract 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 33
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
239000003921 oil Substances 0.000 claims description 21
150000004665 fatty acids Chemical class 0.000 claims description 17
235000014113 dietary fatty acids Nutrition 0.000 claims description 14
229930195729 fatty acid Natural products 0.000 claims description 14
239000000194 fatty acid Substances 0.000 claims description 14
229920001223 polyethylene glycol Polymers 0.000 claims description 12
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 11
-1 hydroxyethyl lactamide Chemical compound 0.000 claims description 10
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 9
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 8
239000002202 Polyethylene glycol Substances 0.000 claims description 8
150000005690 diesters Chemical class 0.000 claims description 8
229940074928 isopropyl myristate Drugs 0.000 claims description 8
238000000034 method Methods 0.000 claims description 8
239000011780 sodium chloride Substances 0.000 claims description 8
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 6
239000003833 bile salt Substances 0.000 claims description 6
229940093761 bile salts Drugs 0.000 claims description 6
238000002360 preparation method Methods 0.000 claims description 6
239000000600 sorbitol Substances 0.000 claims description 6
229940068918 polyethylene glycol 400 Drugs 0.000 claims description 5
JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 4
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
229930195725 Mannitol Natural products 0.000 claims description 4
239000004698 Polyethylene Chemical class 0.000 claims description 4
239000000594 mannitol Substances 0.000 claims description 4
235000010355 mannitol Nutrition 0.000 claims description 4
150000002772 monosaccharides Chemical class 0.000 claims description 4
238000007911 parenteral administration Methods 0.000 claims description 4
239000000825 pharmaceutical preparation Substances 0.000 claims description 4
229940113115 polyethylene glycol 200 Drugs 0.000 claims description 4
229940068886 polyethylene glycol 300 Drugs 0.000 claims description 4
229940083466 soybean lecithin Drugs 0.000 claims description 4
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 3
239000004359 castor oil Substances 0.000 claims description 3
235000019438 castor oil Nutrition 0.000 claims description 3
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 3
238000010438 heat treatment Methods 0.000 claims description 3
238000003756 stirring Methods 0.000 claims description 3
150000005691 triesters Chemical class 0.000 claims description 3
KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-hydroxyoctadecanoic acid Chemical class CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 claims description 2
229940127291 Calcium channel antagonist Drugs 0.000 claims description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims description 2
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 2
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 2
229930006000 Sucrose Natural products 0.000 claims description 2
239000003741 agents affecting lipid metabolism Substances 0.000 claims description 2
230000001476 alcoholic effect Effects 0.000 claims description 2
229930013930 alkaloid Natural products 0.000 claims description 2
150000003797 alkaloid derivatives Chemical class 0.000 claims description 2
125000000217 alkyl group Chemical group 0.000 claims description 2
230000001430 anti-depressive effect Effects 0.000 claims description 2
229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
239000002260 anti-inflammatory agent Substances 0.000 claims description 2
239000003146 anticoagulant agent Substances 0.000 claims description 2
229940127219 anticoagulant drug Drugs 0.000 claims description 2
239000000935 antidepressant agent Substances 0.000 claims description 2
239000003963 antioxidant agent Substances 0.000 claims description 2
230000003078 antioxidant effect Effects 0.000 claims description 2
239000002876 beta blocker Substances 0.000 claims description 2
229940097320 beta blocking agent Drugs 0.000 claims description 2
230000003115 biocidal effect Effects 0.000 claims description 2
239000000480 calcium channel blocker Substances 0.000 claims description 2
229940113088 dimethylacetamide Drugs 0.000 claims description 2
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims description 2
229940093471 ethyl oleate Drugs 0.000 claims description 2
150000002194 fatty esters Chemical class 0.000 claims description 2
229930182478 glucoside Natural products 0.000 claims description 2
239000002955 immunomodulating agent Substances 0.000 claims description 2
229940121354 immunomodulator Drugs 0.000 claims description 2
230000002584 immunomodulator Effects 0.000 claims description 2
229960003444 immunosuppressant agent Drugs 0.000 claims description 2
230000001861 immunosuppressant effect Effects 0.000 claims description 2
239000003018 immunosuppressive agent Substances 0.000 claims description 2
XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 2
229940075495 isopropyl palmitate Drugs 0.000 claims description 2
238000002156 mixing Methods 0.000 claims description 2
239000003176 neuroleptic agent Substances 0.000 claims description 2
230000000701 neuroleptic effect Effects 0.000 claims description 2
125000001095 phosphatidyl group Chemical group 0.000 claims description 2
229940126409 proton pump inhibitor Drugs 0.000 claims description 2
239000000612 proton pump inhibitor Substances 0.000 claims description 2
239000002461 renin inhibitor Substances 0.000 claims description 2
229940086526 renin-inhibitors Drugs 0.000 claims description 2
150000003431 steroids Chemical class 0.000 claims description 2
239000005720 sucrose Substances 0.000 claims description 2
229940114069 12-hydroxystearate Drugs 0.000 claims 1
229940035674 anesthetics Drugs 0.000 claims 1
229940005513 antidepressants Drugs 0.000 claims 1
239000003193 general anesthetic agent Substances 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
229920000573 polyethylene Chemical class 0.000 claims 1
RNVYQYLELCKWAN-UHFFFAOYSA-N solketal Chemical compound CC1(C)OCC(CO)O1 RNVYQYLELCKWAN-UHFFFAOYSA-N 0.000 claims 1
235000008979 vitamin B4 Nutrition 0.000 claims 1
239000011579 vitamin B4 Substances 0.000 claims 1
239000012071 phase Substances 0.000 description 37
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 16
235000019198 oils Nutrition 0.000 description 15
230000004872 arterial blood pressure Effects 0.000 description 11
238000002474 experimental method Methods 0.000 description 11
241000700159 Rattus Species 0.000 description 9
241001465754 Metazoa Species 0.000 description 8
239000000126 substance Substances 0.000 description 8
239000008280 blood Substances 0.000 description 7
210000004369 blood Anatomy 0.000 description 7
238000005191 phase separation Methods 0.000 description 7
239000000839 emulsion Substances 0.000 description 6
RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 description 5
239000003814 drug Substances 0.000 description 5
229960003580 felodipine Drugs 0.000 description 5
239000007788 liquid Substances 0.000 description 5
239000000243 solution Substances 0.000 description 5
239000011521 glass Substances 0.000 description 4
238000001356 surgical procedure Methods 0.000 description 4
101000656751 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 30S ribosomal protein S24e Proteins 0.000 description 3
229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
229920000604 Polyethylene Glycol 200 Polymers 0.000 description 3
229920002556 Polyethylene Glycol 300 Polymers 0.000 description 3
239000013543 active substance Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000009472 formulation Methods 0.000 description 3
239000007789 gas Substances 0.000 description 3
238000001802 infusion Methods 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
239000008279 sol Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
230000007928 solubilization Effects 0.000 description 3
238000005063 solubilization Methods 0.000 description 3
244000025254 Cannabis sativa Species 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
210000001367 artery Anatomy 0.000 description 2
239000000084 colloidal system Substances 0.000 description 2
239000008139 complexing agent Substances 0.000 description 2
OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000003792 electrolyte Substances 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
239000008103 glucose Substances 0.000 description 2
230000000004 hemodynamic effect Effects 0.000 description 2
RXXXUIOZOITBII-UHFFFAOYSA-N indeno[1,2-g]indole Chemical compound C1=C2C=CC=CC2=C2C1=C1N=CC=C1C=C2 RXXXUIOZOITBII-UHFFFAOYSA-N 0.000 description 2
239000006193 liquid solution Substances 0.000 description 2
229920000223 polyglycerol Polymers 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
230000003381 solubilizing effect Effects 0.000 description 2
239000002904 solvent Substances 0.000 description 2
229940124597 therapeutic agent Drugs 0.000 description 2
230000000007 visual effect Effects 0.000 description 2
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 1
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
229920000858 Cyclodextrin Polymers 0.000 description 1
208000037656 Respiratory Sounds Diseases 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
230000003444 anaesthetic effect Effects 0.000 description 1
210000000709 aorta Anatomy 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
125000004429 atom Chemical group 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
230000000059 bradycardiac effect Effects 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
238000004590 computer program Methods 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
239000006184 cosolvent Substances 0.000 description 1
239000004064 cosurfactant Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000008344 egg yolk phospholipid Substances 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
229940072106 hydroxystearate Drugs 0.000 description 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
238000007689 inspection Methods 0.000 description 1
238000001361 intraarterial administration Methods 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
239000002563 ionic surfactant Substances 0.000 description 1
210000004731 jugular vein Anatomy 0.000 description 1
210000004705 lumbosacral region Anatomy 0.000 description 1
239000000463 material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000010907 mechanical stirring Methods 0.000 description 1
229960001620 methohexital sodium Drugs 0.000 description 1
KDXZREBVGAGZHS-UHFFFAOYSA-M methohexital sodium Chemical compound [Na+].CCC#CC(C)C1(CC=C)C(=O)N=C([O-])N(C)C1=O KDXZREBVGAGZHS-UHFFFAOYSA-M 0.000 description 1
FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
239000007764 o/w emulsion Substances 0.000 description 1
239000008188 pellet Substances 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
230000010349 pulsation Effects 0.000 description 1
206010037833 rales Diseases 0.000 description 1
210000002254 renal artery Anatomy 0.000 description 1
238000005549 size reduction Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
238000013222 sprague-dawley male rat Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000008399 tap water Substances 0.000 description 1
235000020679 tap water Nutrition 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Health & Medical Sciences (AREA)
Dispersion Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Colloid Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL12363896A 1995-09-12 1996-09-04 Micromolecules for use as carriers for the release of active compounds IL123638A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9503143A SE9503143D0 (sv)	1995-09-12	1995-09-12	New preparation
PCT/SE1996/001097 WO1997009964A1 (en)	1995-09-12	1996-09-04	Microemulsions for use as vehicles for administration of active compounds

Publications (2)

Publication Number	Publication Date
IL123638A0 IL123638A0 (en)	1998-10-30
IL123638A true IL123638A (en)	2004-06-20

Family

ID=20399446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12363896A IL123638A (en)	1995-09-12	1996-09-04	Micromolecules for use as carriers for the release of active compounds

Country Status (27)

Country	Link
US (1)	US6602511B2 (sv)
EP (1)	EP0850046B1 (sv)
JP (1)	JP4203123B2 (sv)
KR (1)	KR100448953B1 (sv)
CN (1)	CN1160057C (sv)
AT (1)	ATE228822T1 (sv)
AU (1)	AU702366B2 (sv)
BR (1)	BR9610089A (sv)
CA (1)	CA2230730C (sv)
CZ (1)	CZ64398A3 (sv)
DE (1)	DE69625213T2 (sv)
DK (1)	DK0850046T3 (sv)
EE (1)	EE9800070A (sv)
ES (1)	ES2186802T3 (sv)
HU (1)	HUP9901215A3 (sv)
IL (1)	IL123638A (sv)
IS (1)	IS4675A (sv)
MX (1)	MX9801755A (sv)
NO (1)	NO326404B1 (sv)
NZ (1)	NZ318530A (sv)
PL (1)	PL325825A1 (sv)
PT (1)	PT850046E (sv)
RU (1)	RU2164134C2 (sv)
SE (1)	SE9503143D0 (sv)
SK (1)	SK282390B6 (sv)
TR (1)	TR199800437T1 (sv)
WO (1)	WO1997009964A1 (sv)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9503143D0 (sv)	1995-09-12	1995-09-12	Astra Ab	New preparation
US6489346B1 (en)	1996-01-04	2002-12-03	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US5840737A (en)	1996-01-04	1998-11-24	The Curators Of The University Of Missouri	Omeprazole solution and method for using same
US6458373B1 (en)	1997-01-07	2002-10-01	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
US7030155B2 (en)	1998-06-05	2006-04-18	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
ATE462417T1 (de) *	1998-08-13	2010-04-15	Cima Labs Inc	Microemulsionen als feste dosisformen zur oralen verabreichung
DE19859427A1 (de) *	1998-12-22	2000-06-29	Beiersdorf Ag	Kosmetische oder pharmazeutische lecithinhaltige Gele oder niedrigviskose, lecithinhaltige O/W-Mikroemulsionen
GB9912476D0 (en)	1999-05-28	1999-07-28	Novartis Ag	Organic compounds
FR2795960B1 (fr) *	1999-07-05	2001-10-19	Sanofi Elf	Microemulsions stables pour l'administration d'acides gras a l'homme ou a l'animal, et utilisation de ces microemulsions
KR100441167B1 (ko) *	2001-12-27	2004-07-21	씨제이 주식회사	마이크로에멀젼 예비 농축액 조성물
EP1485442A4 (en) *	2002-03-01	2009-11-11	Cesi Chemical A Flotek Co	COMPOSITION AND METHOD FOR CLEANING A WELL
US20050124705A1 (en) *	2002-03-28	2005-06-09	Beiersdorf Ag	Cosmetic or pharmaceutical, low-viscosity oil-in-water emulsions containing phospholipids
DE10213955A1 (de) *	2002-03-28	2003-10-09	Beiersdorf Ag	Kosmetische oder pharmazeutische phospholipidhaltige, niedrigviskose (versprühbare) O/W-Emulsionen
US7811594B2 (en)	2002-03-28	2010-10-12	Beiersdorf Ag	Crosslinked oil droplet-based cosmetic or pharmaceutical emulsions
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1995
- 1995-09-12 SE SE9503143A patent/SE9503143D0/sv unknown
1996
- 1996-09-04 PT PT96931319T patent/PT850046E/pt unknown
- 1996-09-04 CZ CZ98643A patent/CZ64398A3/cs unknown
- 1996-09-04 AU AU70037/96A patent/AU702366B2/en not_active Ceased
- 1996-09-04 RU RU98106482/14A patent/RU2164134C2/ru active
- 1996-09-04 SK SK283-98A patent/SK282390B6/sk unknown
- 1996-09-04 EP EP96931319A patent/EP0850046B1/en not_active Expired - Lifetime
- 1996-09-04 TR TR1998/00437T patent/TR199800437T1/xx unknown
- 1996-09-04 NZ NZ318530A patent/NZ318530A/en not_active IP Right Cessation
- 1996-09-04 WO PCT/SE1996/001097 patent/WO1997009964A1/en active IP Right Grant
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- 1996-09-04 JP JP51187897A patent/JP4203123B2/ja not_active Expired - Fee Related
- 1996-09-04 AT AT96931319T patent/ATE228822T1/de active
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- 1996-09-04 ES ES96931319T patent/ES2186802T3/es not_active Expired - Lifetime
- 1996-09-04 US US08/718,485 patent/US6602511B2/en not_active Expired - Fee Related
- 1996-09-04 KR KR10-1998-0701818A patent/KR100448953B1/ko not_active IP Right Cessation
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- 1996-09-04 DK DK96931319T patent/DK0850046T3/da active
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1998
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Publication number	Publication date
ES2186802T3 (es)	2003-05-16
ATE228822T1 (de)	2002-12-15
EE9800070A (et)	1998-10-15
NZ318530A (en)	1999-09-29
DK0850046T3 (da)	2003-03-03
PL325825A1 (en)	1998-08-03
PT850046E (pt)	2003-03-31
KR19990044569A (ko)	1999-06-25
HUP9901215A3 (en)	2000-06-28
NO981021L (no)	1998-03-09
US20010007663A1 (en)	2001-07-12
EP0850046B1 (en)	2002-12-04
RU2164134C2 (ru)	2001-03-20
NO326404B1 (no)	2008-11-24
NO981021D0 (no)	1998-03-09
CZ64398A3 (cs)	1998-08-12
SK28398A3 (en)	1998-11-04
US6602511B2 (en)	2003-08-05
IL123638A0 (en)	1998-10-30
MX9801755A (es)	1998-08-30
AU7003796A (en)	1997-04-01
DE69625213T2 (de)	2003-08-28
JPH11512424A (ja)	1999-10-26
SE9503143D0 (sv)	1995-09-12
CN1160057C (zh)	2004-08-04
BR9610089A (pt)	1999-01-05
DE69625213D1 (de)	2003-01-16
TR199800437T1 (xx)	1998-05-21
CA2230730C (en)	2008-06-10
IS4675A (is)	1998-02-25
AU702366B2 (en)	1999-02-18
JP4203123B2 (ja)	2008-12-24
WO1997009964A1 (en)	1997-03-20
KR100448953B1 (ko)	2005-04-06
SK282390B6 (sk)	2002-01-07
EP0850046A2 (en)	1998-07-01
CA2230730A1 (en)	1997-03-20
HUP9901215A2 (hu)	1999-08-30
CN1201386A (zh)	1998-12-09

Legal Events

Date	Code	Title
2004-11-24	FF	Patent granted
2005-02-20	KB	Patent renewed
2006-10-30	KB	Patent renewed
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JP3074732B2 (ja)	2000-08-07	脂肪乳剤
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WO2000002534A1 (fr)	2000-01-20	Kit a preparer avant usage avec preparation contenant un medicament et solvant destine a cette fin
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