IL119971A - Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids - Google Patents

Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids

Info

Publication number
IL119971A
IL119971A IL11997197A IL11997197A IL119971A IL 119971 A IL119971 A IL 119971A IL 11997197 A IL11997197 A IL 11997197A IL 11997197 A IL11997197 A IL 11997197A IL 119971 A IL119971 A IL 119971A
Authority
IL
Israel
Prior art keywords
dicarboxylic acids
pharmaceutical compositions
derivatives
compositions containing
novel
Prior art date
Application number
IL11997197A
Other languages
English (en)
Other versions
IL119971A0 (en
Original Assignee
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co filed Critical Yissum Res Dev Co
Priority to IL11997197A priority Critical patent/IL119971A/xx
Publication of IL119971A0 publication Critical patent/IL119971A0/xx
Priority to KR1020077003601A priority patent/KR100806927B1/ko
Priority to CA2277075A priority patent/CA2277075C/en
Priority to PCT/IL1997/000427 priority patent/WO1998030530A1/en
Priority to EP09160514.7A priority patent/EP2112134B1/en
Priority to EP97949080A priority patent/EP0988274B1/en
Priority to US09/331,895 priority patent/US6284903B1/en
Priority to KR1019997006147A priority patent/KR100806928B1/ko
Priority to DE69739415T priority patent/DE69739415D1/de
Priority to AU79947/98A priority patent/AU742945B2/en
Priority to JP53069798A priority patent/JP2001507713A/ja
Priority to AT97949080T priority patent/ATE431816T1/de
Priority to US09/881,812 priority patent/US6800772B2/en
Publication of IL119971A publication Critical patent/IL119971A/xx
Priority to US10/680,429 priority patent/US20040132818A1/en
Priority to JP2009260665A priority patent/JP5479857B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/602—Dicarboxylic acid esters having at least two carbon-to-carbon double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11997197A 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids IL119971A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
AT97949080T ATE431816T1 (de) 1997-01-07 1997-12-25 Carbonsaeuren und ihre derivate und pharmazeutische zusammensetzungen die diese enthalten
US09/331,895 US6284903B1 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
DE69739415T DE69739415D1 (de) 1997-01-07 1997-12-25 Carbonsaeuren und ihre derivate und pharmazeutische zusammensetzungen die diese enthalten
PCT/IL1997/000427 WO1998030530A1 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
EP09160514.7A EP2112134B1 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
EP97949080A EP0988274B1 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
KR1020077003601A KR100806927B1 (ko) 1997-01-07 1997-12-25 카르복실산, 그의 유도체 및 이들을 함유하는 약학적조성물
KR1019997006147A KR100806928B1 (ko) 1997-01-07 1997-12-25 카르복실산, 그의 유도체 및 이들을 함유하는 약학적 조성물
CA2277075A CA2277075C (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
AU79947/98A AU742945B2 (en) 1997-01-07 1997-12-25 Carboxylic acids and derivatives thereof and pharmaceutical compositions contai ning them
JP53069798A JP2001507713A (ja) 1997-01-07 1997-12-25 カルボン酸及びその誘導体及びそれらを含む薬剤組成物
US09/881,812 US6800772B2 (en) 1997-01-07 2001-06-18 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
US10/680,429 US20040132818A1 (en) 1997-01-07 2003-10-08 Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them
JP2009260665A JP5479857B2 (ja) 1997-01-07 2009-11-16 カルボン酸及びその誘導体及びそれらを含む薬剤組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids

Publications (2)

Publication Number Publication Date
IL119971A0 IL119971A0 (en) 1997-04-15
IL119971A true IL119971A (en) 2003-02-12

Family

ID=11069666

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11997197A IL119971A (en) 1997-01-07 1997-01-07 Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids

Country Status (10)

Country Link
US (3) US6284903B1 (xx)
EP (2) EP2112134B1 (xx)
JP (2) JP2001507713A (xx)
KR (2) KR100806927B1 (xx)
AT (1) ATE431816T1 (xx)
AU (1) AU742945B2 (xx)
CA (1) CA2277075C (xx)
DE (1) DE69739415D1 (xx)
IL (1) IL119971A (xx)
WO (1) WO1998030530A1 (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303653B1 (en) 1997-06-26 2001-10-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them

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US6814962B1 (en) * 1994-06-02 2004-11-09 Aventis Pharma S.A. Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
US6410802B1 (en) 1999-04-01 2002-06-25 Esperion Therapeutics, Inc. Methods for synthesizing ether compounds and intermediates therefor
JP2004531459A (ja) 2000-10-11 2004-10-14 エスペリオン セラピューティクス，インコーポレイテッド コレステロールマネージメント用スルホキシドおよびビススルホキシド化合物ならびに組成物および関連する使用
AU2002211666A1 (en) 2000-10-11 2002-04-22 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
MXPA03003020A (es) 2000-10-11 2003-07-14 Esperion Therapeutics Inc Compuestos de cetona y composiciones para el control del colesterol y usos relacionados.
CN1894195A (zh) 2000-10-11 2007-01-10 埃斯佩里安医疗公司 用于控制胆固醇以及相关用途的醚化合物以及组合物
US7304093B2 (en) 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
US7335799B2 (en) 2003-01-23 2008-02-26 Esperion Therapeutics, Inc. Hydroxyl compounds and compositions for cholesterol management and related uses
CA2549995C (en) 2003-12-24 2011-11-15 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
KR20070015114A (ko) * 2003-12-30 2007-02-01 신드로멕스 리미티드 3,3,14,14 테트라메틸 헥사데칸 1,16 이산의 투여 방법
KR101431279B1 (ko) 2005-07-29 2014-08-20 리스버로직스 코퍼레이션 복합 질환의 예방 및 치료용 약학적 조성물 및 삽입가능한의료 장치에 의한 이의 전달
PL2118074T3 (pl) 2007-02-01 2014-06-30 Resverlogix Corp Związki chemiczne do celów profilaktyki i leczenia chorób układu sercowo-naczyniowego
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
US8481084B2 (en) 2007-05-23 2013-07-09 Amcol International Corporation Cholesterol-interacting layered phyllosilicates and methods of reducing hypercholesteremia in a mammal
NZ586440A (en) 2008-06-26 2011-07-29 Resverlogix Corp Methods of preparing quinazolinone derivatives
ES2463097T3 (es) 2009-01-08 2014-05-27 Resverlogix Corp. Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
US9238640B2 (en) 2009-03-18 2016-01-19 Resverlogix Corp. Anti-inflammatory agents
NZ596117A (en) 2009-04-22 2014-10-31 Resverlogix Corp Novel anti-inflammatory agents
MX2012002639A (es) 2009-09-03 2012-03-14 Pfizer Vaccines Llc Vacuna de pcsk9.
WO2012040177A1 (en) 2010-09-20 2012-03-29 Kareus Therapeutics, Sa Methods and compositions for treatment of diabetes and dyslipidemia
EP2680883B1 (en) 2011-03-02 2018-09-05 Pfizer Inc Pcsk9 vaccine
HUE044986T2 (hu) 2011-11-01 2019-11-28 Resverlogix Corp Orális, azonnali felszabadulású készítmények szubsztituált kinazolinonokhoz
WO2013084237A1 (en) 2011-12-08 2013-06-13 Syndromex Ltd. Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
KR20150096794A (ko) 2012-12-21 2015-08-25 제니쓰 에피제네틱스 코포레이션 브로모도메인 저해제로서의 신규한 헤테로사이클릭 화합물
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
CA2978204A1 (en) 2015-03-13 2016-09-22 Esperion Therapeutics, Inc. Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease
CN114984016A (zh) 2015-03-13 2022-09-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CN107118098B (zh) * 2016-02-25 2020-07-14 中国科学院上海药物研究所 一类脂肪酸类化合物、其制备方法及其用途
US11207285B2 (en) 2016-06-02 2021-12-28 Syndromex Ltd. Diabetes treatment regimens using alpha, alpha-substituted long-chain amphipathic carboxylates
US10512624B2 (en) 2016-11-30 2019-12-24 Syndromex Ltd. Long-chain amphipathic dicarboxylic acids for treatment of diabetes type-1
EP3986859A1 (en) 2019-06-21 2022-04-27 Esperion Therapeutics, Inc. Methods of making bempedoic acid and compositions of the same

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GB1268082A (en) 1969-08-08 1972-03-22 Orsymonde Improvements in or relating to bis-(carboxy-alkylene-thio)-decanes
BE755550A (fr) * 1969-09-02 1971-02-01 Parke Davis & Co Acides alcanedioiques, leurs sels et leurs esters abaissant la teneur en triglycerides du serum sanguin
US3930024A (en) * 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
US3773946A (en) * 1969-09-02 1973-11-20 Parke Davis & Co Triglyceride-lowering compositions and methods
FR2288516A2 (fr) * 1974-10-21 1976-05-21 Orsymonde Nouveaux bis-(carboxyalcoylene-thio)-1,10 decanes et leurs derives
IL64542A0 (en) * 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
DE3423166A1 (de) * 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4634975A (en) * 1984-09-17 1987-01-06 Progressive Dynamics, Inc. Method and apparatus for producing electromagnetic surveillance fields
JPS61171417A (ja) * 1985-01-23 1986-08-02 Wakunaga Seiyaku Kk 抗糖尿病剤
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3634356A1 (de) * 1986-10-08 1988-04-21 Epis Sa Arzneimittel enthaltend alpha-halogenierte dicarbonsaeuren
DE4224670A1 (de) * 1992-07-25 1994-01-27 Boehringer Mannheim Gmbh Verwendung von â,w-Dicarbonsäuren als Fibrinogensenker
US5648387A (en) * 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
JP2003001549A (ja) * 2001-06-26 2003-01-08 Howa Mach Ltd 光電式刃具折れ検知装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303653B1 (en) 1997-06-26 2001-10-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Carboxylic acids and derivatives thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP2112134A1 (en) 2009-10-28
KR20000069934A (ko) 2000-11-25
US20020049345A1 (en) 2002-04-25
WO1998030530A1 (en) 1998-07-16
CA2277075C (en) 2010-06-22
EP2112134B1 (en) 2013-10-30
DE69739415D1 (de) 2009-07-02
US6284903B1 (en) 2001-09-04
JP2010077141A (ja) 2010-04-08
EP0988274B1 (en) 2009-05-20
EP0988274A4 (en) 2000-10-18
EP0988274A1 (en) 2000-03-29
AU742945B2 (en) 2002-01-17
AU7994798A (en) 1998-08-03
KR100806928B1 (ko) 2008-02-22
US6800772B2 (en) 2004-10-05
CA2277075A1 (en) 1998-07-16
IL119971A0 (en) 1997-04-15
KR100806927B1 (ko) 2008-02-22
JP5479857B2 (ja) 2014-04-23
JP2001507713A (ja) 2001-06-12
US20040132818A1 (en) 2004-07-08
KR20070026888A (ko) 2007-03-08
ATE431816T1 (de) 2009-06-15

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees