IE970360A1 - Delayed-action acidifying additive for animal feed and¹processes for its use - Google Patents
Delayed-action acidifying additive for animal feed and¹processes for its useInfo
- Publication number
- IE970360A1 IE970360A1 IE970360A IE970360A IE970360A1 IE 970360 A1 IE970360 A1 IE 970360A1 IE 970360 A IE970360 A IE 970360A IE 970360 A IE970360 A IE 970360A IE 970360 A1 IE970360 A1 IE 970360A1
- Authority
- IE
- Ireland
- Prior art keywords
- additive
- support
- acidifying
- weight
- alkaline
- Prior art date
Links
- 239000000654 additive Substances 0.000 title claims abstract description 44
- 230000000996 additive effect Effects 0.000 title claims abstract description 41
- 241001465754 Metazoa Species 0.000 title claims abstract description 24
- 239000002253 acid Substances 0.000 claims abstract description 24
- 230000001079 digestive effect Effects 0.000 claims abstract description 11
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 10
- 230000008569 process Effects 0.000 claims abstract description 8
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 6
- 239000011707 mineral Substances 0.000 claims abstract description 6
- 230000006872 improvement Effects 0.000 claims abstract description 5
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 30
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 15
- 235000019253 formic acid Nutrition 0.000 claims description 15
- 230000000050 nutritive effect Effects 0.000 claims description 11
- 150000007513 acids Chemical group 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000000377 silicon dioxide Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 235000012211 aluminium silicate Nutrition 0.000 claims description 3
- 229920001222 biopolymer Polymers 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- 150000004781 alginic acids Chemical group 0.000 claims description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 2
- 229910000323 aluminium silicate Inorganic materials 0.000 claims description 2
- 239000010775 animal oil Substances 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 2
- 150000004760 silicates Chemical class 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 235000012222 talc Nutrition 0.000 claims description 2
- 239000008158 vegetable oil Substances 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 239000010455 vermiculite Substances 0.000 claims description 2
- 229910052902 vermiculite Inorganic materials 0.000 claims description 2
- 235000019354 vermiculite Nutrition 0.000 claims description 2
- 239000010457 zeolite Substances 0.000 claims description 2
- 239000005995 Aluminium silicate Substances 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 238000004321 preservation Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 description 9
- 230000000694 effects Effects 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 235000019621 digestibility Nutrition 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 230000000750 progressive effect Effects 0.000 description 4
- 210000000813 small intestine Anatomy 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 235000021050 feed intake Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 229910052622 kaolinite Inorganic materials 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 230000020477 pH reduction Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- CBOCVOKPQGJKKJ-UHFFFAOYSA-L Calcium formate Chemical compound [Ca+2].[O-]C=O.[O-]C=O CBOCVOKPQGJKKJ-UHFFFAOYSA-L 0.000 description 1
- 102000005367 Carboxypeptidases Human genes 0.000 description 1
- 108010006303 Carboxypeptidases Proteins 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 241000195480 Fucus Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010059881 Lactase Proteins 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 241001466453 Laminaria Species 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 239000004118 Natrolite-phonolite Substances 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 241000255969 Pieris brassicae Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- -1 algal powders Natural products 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 102000016679 alpha-Glucosidases Human genes 0.000 description 1
- 108010028144 alpha-Glucosidases Proteins 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 229940127090 anticoagulant agent Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000004281 calcium formate Substances 0.000 description 1
- 229940044172 calcium formate Drugs 0.000 description 1
- 235000019255 calcium formate Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229940116108 lactase Drugs 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013384 milk substitute Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 235000019358 natrolite-phonolite Nutrition 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000017363 positive regulation of growth Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 230000003019 stabilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
Abstract
The invention concerns a delayed-action acidifying additive suitable for animal feed, the said additive containing at least a strong acid that is compatible with the digestive functioning of animals, the strong acid(s) being bonded with at least an organic or mineral, particulate support that is compatible with the digestive functioning of animals. The invention also concerns processes for the use of such an acidifying additive for the improvement of the digestive functions of an animal by lowering the pH of the digestive tract, and for the preservation of ensilaged fodder.
Description
DELAYED-ACTION ACIDIFYING ADDITIVE FOR ANIMAL FEED AND PROCESSES FOR ITS USE The present invention concerns delayed-action acidifying additives suitable for animal food, that is to say, additives whose acidifying action is progressive and continues over time, and processes for the use of these additives to improve the digestive functions of an animal by lowering the pH of its digestive tract.
It is known that the digestive tract of some animals at the time of weaning is unsuited to the digestion of maternal milk substitute foods and that this deficiency of the digestive tract constitutes a particularly large problem at industrial breeding installations. For example, in the case of the piglet, this deficiency is mainly due to the insufficient production of hydrochloric acid and lactic acid by the stomach; the secretion of these is in fact deficient during the first three weeks of life and only reaches levels compatible with good proteinic digestion and optimum intestinal protection from the third or fourth week after weaning. At the time of weaning, the passage of poorly degraded nutriments into the intestines causes serious digestive disturbances manifested in diarrhoea and hepatic deficiencies. At the microbiological level, weaning can cause an imbalance of the intestinal microbial flora owing to the low level of acidity of the intestinal tract; in the case of the piglet, because gastric pH does not fall below 3 until the sixtieth day of life, before this time has passed the stomach does not play its role as a barrier with regard to undesirable microorganisms such as Escherichia coli or pathogenic microorganisms which will colonise the small intestine. At the enzvmatic level, aciditv also affectsthe functioning ί .........................1 I'· « OPEN TO PUBLIC INSPECTION I ί 15,! f.: Γ5 UHOEP SECTION 28 AND RULE 23 JNL Wo /£26 -2and activity of several enzymes of the intestinal tract, such as pepsin, and pancreatic enzymes such as trypsin, chymotrypsin, carboxypeptidase, amylase, lipase, maltase and lactase; the consequence of these dysfunctions manifests itself in the poor digestibility of foods in the diet, which is harmful to nutritive efficiency and to growth.
Much work has been undertaken to remedy this lack of acidity and various methods of acidification have been proposed. Thus, numerous publications have proposed the direct addition of mineral or organic acids or of mixtures of acids and/or salts thereof, to the feed intake of the weaned piglet. For example, JOST and BRACHER-JAKOB (1991, Utilisation d’acides organiques dans 1'alimentation des porcelets d'elevage, Revue Suisse Agric. 23 (2), 73-76) have studied the effects of adding citromix (a mixture of acids) at 0.8% or fumaric acid at 1.2% or calcium formate at 1.2% to food for piglets, on the average daily gain (A.D.G.), on the index of consumption, on digestibility and on the frequency of diarrhoea. In this study, they observed only a slight influence of these acids on the digestibility of the nitrogenous material. This procedure of adding pure acids has the disadvantage of bringing about a fall In the gastric pH to a value below 3.5, thus disturbing the natural secretion of hydrochloric acid by the peripheral cells of the animal’s stomach and inhibiting the production of lactic acid by the Lactobacillus spp. Moreover, these free acids are too rapidly absorbed to produce beneficial effects and they do not reach the small intestine.
There is therefore a need to use acid in a form that gives it a progressive effect continuing over time so as to avoid a sudden drop in the pH at the time of ingestion of the food by the piglet and to permit the -3ΙΕ 970360 acid to have an effect at the level of the small intestine. In order to obtain an acid which has a progressive action continuing over time, it has been proposed (Feed mix, Vol.2, No. 3, 1994, pages 23-25) to use mineral or organic acids arranged in a layer inside a lipid matrix. The acids protected in this way by a lipid matrix have a delayed action and are therefore more effective than pure acids, but their cost is high.
An aim of the present invention is to propose a delayed-action acidifying additive suitable for addition to animal feed, that is, an additive from which an acid can be released progressively over time. Another aim of the invention is to propose an acidifying additive which can be used in a nutriment for animals in order to lower the pH of the digestive tract. A third aim of the invention is to propose an acidifying additive with a low cost price.
Subject matter of the invention, therefore, is a delayed-action acidifying additive suitable for animal feed, the said additive containing at least a strong acid that is compatible with the digestive functions of animals, characterised in that the strong acid is formic acid and in that it is bonded at least with an organic or mineral, particulate, hydrophilic support that is compatible with the digestive functioning of animals.
Formic acid is in fact a much stronger acid than its superior homologues; it has an excellent acidification capacity owing to the high value of its dissociation constant (pKs - 3.75). Moreover, tests have shown that, in piglet rearing, it is a source of better results than other acids, not only for digestibility of nutriments but also for the reduction of diarrhoea and the stimulation of growth.
In the matter of chemistry, pure formic acid is unstable and a certain water content is necessary for -4IE 970360 stabilising it; at ambient temperature, formic acid decomposes as soon as it is totally dehydrated. According to the invention, by associating formic acid with a hydrophilic, pulverulent support which has a high water retention capacity and which is compatible in nutritive terms with the digestive physiology of animals, its molecular stability is increased and it can be incorporated into an animal feed intake in pulverulent form.
According to the invention, the hydrophilic support serves to provide an active, stable acidifying additive having a particulate structure. This support can therefore have great affinity for water provided that it adsorbs and/or absorbs the water without any important variation in its structure or properties, in order to be capable of transforming the acid or acid solution bonded with the support into sufficiently fluid powder. As used within the context of the present invention, the terms bonded" or bond cover forms of bonding of the acid with the support, which are variable according to the support. The bonds can be hydrogen bonds by electrovalency, for example in the case of silicas and alginates, or else an adsorption possibly combined with a chemical bond, for example in the case of clays.
The bonding of formic acid with the support enables its acidifying power to be maintained for longer, since it is released only progressively from the additive. It enables the release of formic acid into the whole of the digestive tract, including the small intestine part and, furthermore, at a given point, this release is more progressive and thus more effective owing to the less rapid absorption of the mucous membranes.
The particulate or pulverulent form of the acidifying additive enables the contact surface to be -5IE 970360 increased with a view to the release of formic acid.
The support must therefore be resistant to settling and not have a tendency to form agglomerates.
Suitable supports according to the invention are advantageously chosen from the group formed by: hydrophilic mineral products of natural and/or synthetic origin chosen from silica, in particular pyrogenous or precipitated silica, alumina? alkaline-earth silicates, in particular talcum; aluminium silicates, in particular clays such as kaolinite, montmorillonite, bentonite, vermiculite? and alkaline or alkaline-earth silicoaluminates, in particular zeolites such as natrolitephonolite; biodegradable organic products, in particular biopolymers such as alginic acids and salts thereof, in particular ammonium, sodium, potassium, magnesium or calcium salts; pulverised biodegradable natural products such as algal powders, in particular micronized algal powders obtained from Fucus spp, Laminaria spp or Rscophyllum spp.
Preferably, the support has a size grading between 10 nm and 10 mm.
The quantity of support(s) advantageously represents from 30% to 75% by weight of the total weight of the acidifying additive according to the invention. In addition to formic acid and the support, the acidifying additive can contain at least one active constituent, other than formic acid, bonded with the support(s) and/or formulation adjuvants. A vegetable or animal oil added in small quantities, preferably at the rate of 1% to 8% by weight so as not to destroy the pulverulent aspect of the additive, can be mentioned as the other active constituent. An anti-clotting agent ίΕ 970360 -6such as magnesium stearate can be mentioned as the adjuvant.
Further subject matter of the present invention is a process for improving the digestive functions of an animal by lowering the pH of the digestive tract, in which process an acidifying additive according to the invention is added to the nutritive intake of the animal. The quantity of acidifying additive that is added is preferably between 0.2% and 10% by weight in relation to the weight of the nutritive intake; this quantity is preferably in the region of 1% by weight. The nutritive intake is preferably a nutritive intake for a young animal, in particular a piglet; in a particularly advantageous way, the nutritive intake is a nutritive intake for a piglet in the first phase after weaning, that is to say, for the 14 days following weaning.
The examples given below by way of illustration and in a non-restrictive manner, will permit a better understanding of the invention.
EXAMPLE 1 In the powdered sodium alginate there is incorporated 35% by weight formic acid at 85% by dropping the formic acid drop by drop into the alginate while mixing carefully to avoid clotting. The acidifying additive that is obtained can be preserved without degradation of the formic acid for six months in a flask that is impervious to ultra-violet rays.
EXAMPLE 2 There is incorporated 60% by weight of formic acid at 85% of a mixture constituted by 62.5% by weight of hydrophilic silica, 25% of kaolinite and 12.5% of algal proteinic concentrate. 5% by weight of soya oil is then introduced to this mixture. -7The additive that is thus obtained is then incorporated in a first-age" piglet food commercially produced by the company GUILDALI, at the rate of 2 to 20 kg in weight of additive for 1 tonne in weight of food. The buffer capacity of the food has passed from 920 meq/kg to 700 meq/kg. There has thus been achieved a buffer capacity of less than 750 meq/kg, which is consequently unfavourable to the development of Escherichia Coli in the case of the piglet.
EXAMPLE 3 As in Example 1, an acidifying additive was prepared and mixed with the piglet food in an industrial mixer at the rate of 10 kg/tonne.
Three categories of tests were carried out at a birth and fattening farm of 300 Large White x Landrace sows, on a total of 450 piglets.
Tests 1 and 2 were carried out during the period of use of a first-age nutriment, that is to say, from weaning to the 14th day after weaning. Test 3 was carried out over a period covering both the first-age phase and the second-age phase. The following parameters were measured: Consumption of nutriments (g/day), Average daily gain (g) (ADG), Index of conversion.
A reference batch of piglets consuming the same nutriment but without acidifying additive, was studied by way of a comparison. -8TABLE 1 Reference batch Batch with additive Number 72 71 Weight at weaning (kg) 7.7 7.5 Weight at end of test (kg) 11.25 12 Duration of test (in days) 14 14 Consumption g/day 265 327 I Average daily gain (g) 253 321 Index of conversion 1.05 1.02 j TABLE 2 Reference batch Batch with additive Number 70 70 Weight at weaning (kg) 8.37 8.71 Weight at end of test (kg) 11.27 12.47 Duration of test (in days) 14 14 -9IE 970360 Consumption g/day 306 382 Average daily gain (g) 207 268 Index of conversion 1.47 1.42 TABLE 3 10 15 Reference batch Batch with additive Number 67 68 Weight at weaning (kg) 8.74 8.97 Weight at day 14 (kg) 11.77 12.83 Average daily gain at day 14 (g) 216 276 20 Weight at day 54 (kg) 35.11 36.41 Average daily gain day 14 to day 54 (g) 583 589 25 Average daily gain day 0 to day 54 (g) 488 508 Index of conversion 1.67 1.62 -10IE 970360 Tables 1 and 2 show that the presence of the acidifying additive in a first-age nutriment enables the consumption and the average daily gain (ADG) to be improved. The improvement in consumption is 23% in Table 1 and 24% in Table 2 and the improvement in ADG is 26% in Table 1 and 29% in Table 2.
Table 3 confirms the improvement in ADG in the first period. With the second-age nutriment, the effect of the addition of the acidifying additive on the ADG is less significant. However, a sanitary effect is observed: the reduction of diarrhoea.
Claims (11)
1. Delayed-action acidifying additive suitable for animal feed, the said additive containing at least a strong acid, characterised in that the strong acid is formic acid and in that it is bonded at least with an organic or mineral, particulate, hydrophilic support that is compatible with the digestive functioning of animals.
2. Additive according to claim 1, characterised in that the support(s) is (are) chosen from the group formed by silica, alumina, alkaline and alkaline-earth silicates, aluminium silicates, and alkaline or alkaline-earth silicoaluminates, biopolymers, algal powders and mixtures thereof.
3. Additive according to claim 2, characterised in that the biopolymer is alginic acid or the ammonium, alkaline or alkaline-earth salts thereof.
4. Additive according to claim 3, characterised in that the support(s) is (are) chosen from the group formed by talcum, kaolin!te, montmorillonite, bentonite, vermiculite and zeolites.
5. Additive according to one of claims 1 to 4, characterised in that the support(s) has (have) a size grading between 10 nm and 10 mm.
6. Additive according to one of claims 1 to 5, characterised in that the quantity of support(s) represents from 30% to 75% by weight of the total weight of the acidifying additive.
7. Additive according to one of claims 1 to 6, characterised in that it contains at least one active constituent other than the strong acid (or acids) bonded with the support(s) and/or at least one formulation adjuvant.
8. Additive according to claim 7, characterised in that it contains from 1% to 8% by weight of a vegetable or animal oil. -129.
9.Process for the improvement of the digestive functions of an animal by lowering the pH of its digestive tract, characterised in that an acidifying additive according to one of claims 1 to 8 is added to 5 the nutritive intake of the animal.
10. Process according to claim 9, characterised in that the quantity of acidifying additive that is added is between 0.2% and 10% by weight in relation to the weight of the nutritive intake. 10
11. Process according to one of claims 9 or 10, characterised in that the nutritive intake is an intake for a piglet in the first phase after weaning.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9606206A FR2748635B1 (en) | 1996-05-20 | 1996-05-20 | DELAY EFFECT ACIDIFYING ADDITIVES FOR ANIMAL FEEDING AND METHODS OF IMPLEMENTATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IE970360A1 true IE970360A1 (en) | 1997-12-03 |
Family
ID=9492262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE970360A IE970360A1 (en) | 1996-05-20 | 1997-05-19 | Delayed-action acidifying additive for animal feed and¹processes for its use |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE1010491A3 (en) |
| DE (1) | DE19720703A1 (en) |
| ES (1) | ES2127139B1 (en) |
| FR (1) | FR2748635B1 (en) |
| GB (1) | GB2313287A (en) |
| IE (1) | IE970360A1 (en) |
| IT (1) | IT1292355B1 (en) |
| LU (1) | LU90060B1 (en) |
| NL (1) | NL1006014C2 (en) |
| PT (1) | PT102008A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9807287D0 (en) * | 1998-04-03 | 1998-06-03 | Verdugt Bv | Biocidal compositions |
| FI113003B (en) * | 2000-03-01 | 2004-02-27 | Kemira Chemicals Oy | Solid formic acid product |
| CN113875896B (en) * | 2021-10-11 | 2024-02-09 | 浙江省农业科学院 | Feed additive for treating and preventing pig intestinal tract injury |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4816307B1 (en) * | 1969-09-04 | 1973-05-21 | ||
| AR206283A1 (en) * | 1971-01-27 | 1976-07-15 | Chinoin Gyogyszer Es Vegyeszet | A COMPOSITION FOR THE PRESERVATION OF PRODUCTS OF ANIMAL OR PLANT ORIGIN |
| CH613607A5 (en) * | 1975-06-11 | 1979-10-15 | Lonza Ag | Ensiling agent and process for preparation thereof |
| US4199606A (en) * | 1977-09-22 | 1980-04-22 | Bland Bobby | Propionic acid on a carrier material as a preservative |
| JPS56121436A (en) * | 1980-02-29 | 1981-09-24 | Kyodo Shiryo Kk | Formula stock feed |
| GB8525061D0 (en) * | 1985-10-10 | 1985-11-13 | Bp Chem Int Ltd | Antimicrobial additives |
| JPS63152948A (en) * | 1986-12-17 | 1988-06-25 | Nissei Yakuhin Kk | Additive in feed composition for young animal, feed composition and feeding thereof |
| SU1461398A1 (en) * | 1987-12-11 | 1989-02-28 | А.Ф. Пономарев, А.Т. Гнилицкий, В.Г. Правдин, А.Н. Моргунов, Ю.Д.Панаев, В.А. Бондарев, А.А. Панов, , Т.е. Моргунова, Т.Г. Андроникашвили, Н.А. Филиппов и А.А. Шапошников | Agent for preserving green feed |
| JPH01279814A (en) * | 1989-03-27 | 1989-11-10 | Nisshin Flour Milling Co Ltd | Fungicide for feed |
| CN1018144B (en) * | 1990-02-06 | 1992-09-09 | 北京市营养源研究所 | Feed for fish and shrimp containing stale-proof and anti-oxygenic agent |
| JP2925703B2 (en) * | 1990-10-08 | 1999-07-28 | 株式会社中埜酢店 | How to feed pigs |
| US5637312A (en) * | 1995-03-29 | 1997-06-10 | Tock; Richard W. | Digestion enhancer for ruminant animals comprising a formate salt |
-
1996
- 1996-05-20 FR FR9606206A patent/FR2748635B1/en not_active Expired - Fee Related
-
1997
- 1997-04-30 BE BE9700392A patent/BE1010491A3/en not_active IP Right Cessation
- 1997-05-07 LU LU90060A patent/LU90060B1/en active
- 1997-05-09 NL NL1006014A patent/NL1006014C2/en not_active IP Right Cessation
- 1997-05-14 GB GB9709799A patent/GB2313287A/en not_active Withdrawn
- 1997-05-16 DE DE19720703A patent/DE19720703A1/en not_active Withdrawn
- 1997-05-19 PT PT102008A patent/PT102008A/en not_active Application Discontinuation
- 1997-05-19 IE IE970360A patent/IE970360A1/en not_active IP Right Cessation
- 1997-05-19 ES ES009701066A patent/ES2127139B1/en not_active Expired - Fee Related
- 1997-05-19 IT IT97TO000421A patent/IT1292355B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| FR2748635A1 (en) | 1997-11-21 |
| FR2748635B1 (en) | 1998-10-30 |
| ITTO970421A1 (en) | 1998-11-19 |
| NL1006014A1 (en) | 1997-11-21 |
| DE19720703A1 (en) | 1997-11-27 |
| NL1006014C2 (en) | 1997-11-21 |
| PT102008A (en) | 1997-11-28 |
| ES2127139B1 (en) | 1999-12-01 |
| BE1010491A3 (en) | 1998-10-06 |
| LU90060B1 (en) | 1997-12-08 |
| GB2313287A (en) | 1997-11-26 |
| IT1292355B1 (en) | 1999-01-29 |
| GB9709799D0 (en) | 1997-07-09 |
| ITTO970421A0 (en) | 1997-05-19 |
| ES2127139A1 (en) | 1999-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed | ||
| MM4A | Patent lapsed | ||
| ERR | Erratum |
Free format text: PATENTS EXPIRED IN JOURNAL NO. 2013 OF 20050209, IN THE LIST OF PATENTS EXPIRED, PATENT NO. 83298 WAS ADVERTISED IN ERROR. THIS PATENT IS STILL IN FORCE. |