IE901554L - Polypeptides - Google Patents
PolypeptidesInfo
- Publication number
- IE901554L IE901554L IE901554A IE155490A IE901554L IE 901554 L IE901554 L IE 901554L IE 901554 A IE901554 A IE 901554A IE 155490 A IE155490 A IE 155490A IE 901554 L IE901554 L IE 901554L
- Authority
- IE
- Ireland
- Prior art keywords
- terminal
- terminal portion
- hsa
- variant
- polypeptide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 210000004899 c-terminal region Anatomy 0.000 abstract 4
- 230000028327 secretion Effects 0.000 abstract 2
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 abstract 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A fusion polypeptide comprising, as at least part of the N-terminal portion thereof, an N-terminal portion of HSA or a variant thereof and, as at least part of the C-terminal portion thereof, another polypeptide except that, when the said N-terminal portion of HSA is the 1-n portion where n is 369 to 419 or a variant thereof, then the said polypeptide is one of various specified entities, including the 585 to 1578 portion of human fibronectin or a variant thereof. The HSA-like portion may have additional N-terminal residues, such as secretion leader sequences (signal sequences). The C-terminal portion is preferably the 585-1578 portion of human plasma fibronectin. The N-terminal and C-terminal portions may be cleavable to yield the isolated C-terminal portion, with the N-terminal portion having served to facilitate secretion from the host.
[GB2246783A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898909916A GB8909916D0 (en) | 1989-04-29 | 1989-04-29 | Polypeptides |
Publications (2)
Publication Number | Publication Date |
---|---|
IE901554L true IE901554L (en) | 1990-10-29 |
IE67651B1 IE67651B1 (en) | 1996-04-17 |
Family
ID=10656000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE155490A IE67651B1 (en) | 1989-04-29 | 1990-04-27 | Polypeptides |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0470165A1 (en) |
JP (1) | JP2781459B2 (en) |
KR (1) | KR100227167B1 (en) |
AU (1) | AU630450B2 (en) |
CA (1) | CA2015687C (en) |
FI (1) | FI104255B (en) |
GB (2) | GB8909916D0 (en) |
HU (1) | HUT61049A (en) |
IE (1) | IE67651B1 (en) |
IL (1) | IL94243A (en) |
WO (1) | WO1990013653A1 (en) |
ZA (1) | ZA903237B (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5629287A (en) * | 1991-01-18 | 1997-05-13 | University College London | Depot formulations |
US5610148A (en) * | 1991-01-18 | 1997-03-11 | University College London | Macroscopically oriented cell adhesion protein for wound treatment |
FR2686899B1 (en) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
FR2686900B1 (en) * | 1992-01-31 | 1995-07-21 | Rhone Poulenc Rorer Sa | NOVEL POLYPEPTIDES HAVING GRANULOCYTE COLONY STIMULATION ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
WO1994016085A2 (en) * | 1992-12-30 | 1994-07-21 | Zymogenetics, Inc. | Hybrid proteins having cross-linking and tissue-binding activities |
GB9408466D0 (en) * | 1994-04-27 | 1994-06-22 | Univ Nottingham | Cloning and functional expression of neurotoxins |
US5543308A (en) * | 1994-10-18 | 1996-08-06 | New England Biolabs, Inc. | Isolated DNA encoding the FSEI restriction endonuclease and related methods for producing the same |
US5877149A (en) | 1995-06-07 | 1999-03-02 | Beaulieu; Andre | Deepithelialized skin diffusion cell system |
US5641483A (en) * | 1995-06-07 | 1997-06-24 | Beaulieu; Andre | Wound healing formulations containing human plasma fibronectin |
PE99498A1 (en) * | 1996-07-26 | 1999-01-21 | Novartis Ag | FUSION POLYPEPTIDES |
US6423512B1 (en) | 1996-07-26 | 2002-07-23 | Novartis Ag | Fusion polypeptides |
US5932693A (en) * | 1996-12-10 | 1999-08-03 | Washington University | Antithrombotic peptides |
KR20010034305A (en) | 1998-01-23 | 2001-04-25 | 한센 핀 베네드 | Process for making desired polypeptides in yeast |
JP4087563B2 (en) | 1998-06-15 | 2008-05-21 | ジーティーシー バイオセラピューティックス インコーポレイテッド | Erythropoietin analog-human serum albumin fusion |
US20030171267A1 (en) * | 2000-04-12 | 2003-09-11 | Rosen Craig A. | Albumin fusion proteins |
TWI315740B (en) | 2001-08-15 | 2009-10-11 | Takara Bio Inc | |
EP1997829A1 (en) | 2001-12-21 | 2008-12-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
DE60335253D1 (en) | 2002-03-25 | 2011-01-20 | Takara Bio Inc | METHOD OF PRODUCING A CYTOTOXIC LYMPHOCYTE |
CN1839202B (en) * | 2003-08-22 | 2012-07-18 | 宝生物工程株式会社 | Process for producing cytotoxic lymphocytes |
EP3192872A1 (en) | 2003-08-26 | 2017-07-19 | The Regents of the University of Colorado, a body corporate | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
AU2005317828A1 (en) | 2004-12-23 | 2006-06-29 | Novozymes Delta Limited | Gene expression technique |
EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
WO2007146038A2 (en) | 2006-06-07 | 2007-12-21 | Human Genome Sciences, Inc. | Albumin fusion proteins |
DK2049560T3 (en) | 2006-07-13 | 2013-07-29 | Novozymes Biopharma Dk As | Process for the preparation of particles of proteinaceous material |
US9493545B2 (en) | 2009-02-11 | 2016-11-15 | Albumedix A/S | Albumin variants and conjugates |
KR101874834B1 (en) | 2009-10-30 | 2018-07-05 | 알부메딕스 에이/에스 | Albumin variants |
CN106977608A (en) | 2010-04-09 | 2017-07-25 | 阿尔布麦狄克斯公司 | Albumin derivant and variant |
JP6216921B2 (en) | 2011-06-24 | 2017-11-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
WO2013075066A2 (en) | 2011-11-18 | 2013-05-23 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
EP3330283A3 (en) | 2012-03-16 | 2018-07-11 | Albumedix A/S | Albumin variants |
GB2512156A (en) | 2012-11-08 | 2014-09-24 | Novozymes Biopharma Dk As | Albumin variants |
US20160152686A1 (en) | 2013-03-13 | 2016-06-02 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or moiety binding thereto |
US10633428B2 (en) | 2015-08-20 | 2020-04-28 | Albumedix Ltd | Albumin variants and conjugates |
EP3538560A4 (en) * | 2016-11-10 | 2020-06-17 | Keros Therapeutics, Inc. | Gdnf fusion polypeptides and methods of use thereof |
EP3873926A1 (en) * | 2018-10-29 | 2021-09-08 | Spin Therapeutics, LLC | Compositions and methods for alpha-1-antitrypsin disorders |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE459586B (en) * | 1987-09-14 | 1989-07-17 | Mta Szegedi Biolog Koezponti | THE STRUCTURES CODING FOR AUTHENTIC HUMAN SERUM ALBUMIN AND PROCEDURES FOR ITS PREPARATION |
GB8725529D0 (en) * | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
-
1989
- 1989-04-29 GB GB898909916A patent/GB8909916D0/en active Pending
-
1990
- 1990-04-26 JP JP2506978A patent/JP2781459B2/en not_active Expired - Lifetime
- 1990-04-26 EP EP90907285A patent/EP0470165A1/en active Pending
- 1990-04-26 AU AU55646/90A patent/AU630450B2/en not_active Expired
- 1990-04-26 WO PCT/GB1990/000650 patent/WO1990013653A1/en active IP Right Grant
- 1990-04-26 HU HU904413A patent/HUT61049A/en unknown
- 1990-04-27 CA CA002015687A patent/CA2015687C/en not_active Expired - Lifetime
- 1990-04-27 ZA ZA903237A patent/ZA903237B/en unknown
- 1990-04-27 IE IE155490A patent/IE67651B1/en not_active IP Right Cessation
- 1990-04-29 IL IL9424390A patent/IL94243A/en not_active IP Right Cessation
-
1991
- 1991-09-06 GB GB9119043A patent/GB2246783B/en not_active Expired - Lifetime
- 1991-10-14 KR KR1019910701334A patent/KR100227167B1/en not_active IP Right Cessation
- 1991-10-28 FI FI915073A patent/FI104255B/en active
Also Published As
Publication number | Publication date |
---|---|
CA2015687A1 (en) | 1990-10-29 |
IE67651B1 (en) | 1996-04-17 |
JP2781459B2 (en) | 1998-07-30 |
WO1990013653A1 (en) | 1990-11-15 |
FI104255B1 (en) | 1999-12-15 |
GB2246783A (en) | 1992-02-12 |
GB2246783B (en) | 1992-10-14 |
FI915073A0 (en) | 1991-10-28 |
EP0470165A1 (en) | 1992-02-12 |
IL94243A0 (en) | 1991-01-31 |
IL94243A (en) | 1995-10-31 |
AU5564690A (en) | 1990-11-29 |
KR100227167B1 (en) | 1999-10-15 |
GB8909916D0 (en) | 1989-06-14 |
JPH04506598A (en) | 1992-11-19 |
FI104255B (en) | 1999-12-15 |
KR920701451A (en) | 1992-08-11 |
CA2015687C (en) | 2000-08-29 |
HUT61049A (en) | 1992-11-30 |
ZA903237B (en) | 1991-03-27 |
HU904413D0 (en) | 1992-01-28 |
AU630450B2 (en) | 1992-10-29 |
GB9119043D0 (en) | 1991-12-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK9A | Patent expired |