IE893481L - THE USE OF 4H-1-benzopyran-4-one derivatives, novel¹4H-1-benzopyran-4-one derivatives, and pharmaceuticals¹containing them - Google Patents
THE USE OF 4H-1-benzopyran-4-one derivatives, novel¹4H-1-benzopyran-4-one derivatives, and pharmaceuticals¹containing themInfo
- Publication number
- IE893481L IE893481L IE893481A IE348189A IE893481L IE 893481 L IE893481 L IE 893481L IE 893481 A IE893481 A IE 893481A IE 348189 A IE348189 A IE 348189A IE 893481 L IE893481 L IE 893481L
- Authority
- IE
- Ireland
- Prior art keywords
- benzopyran
- derivatives
- novel14h
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Compounds of the formula I <IMAGE> in which the substituents R1-R5 and n and m have the said meanings, are suitable for controlling tumours. The present invention relates to the use of 4H-1-benzopyran-4-one derivatives, to 4H-1-benzopyran-4-one derivatives and to medicines containing same. Benzopyran derivatives have already been disclosed in European Patent No. 0137193 and German Offenlegungsschrift 36 12 337. In the latter, compounds of the formula a) are disclosed.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3836676A DE3836676A1 (en) | 1988-10-28 | 1988-10-28 | THE USE OF 4H-1-BENZOPYRAN-4-ON DERIVATIVES, NEW 4H-1-BENZOPYRAN-4-ON DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM |
Publications (2)
Publication Number | Publication Date |
---|---|
IE893481L true IE893481L (en) | 1990-04-28 |
IE69982B1 IE69982B1 (en) | 1996-10-16 |
Family
ID=6366059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE348189A IE69982B1 (en) | 1988-10-28 | 1989-10-27 | Use of 4H-1-benzopyran-4-one derivatives 4H-1-benzopyran-4-one derivatives and medicines containing same |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0366061B1 (en) |
JP (1) | JP2879910B2 (en) |
KR (1) | KR100194505B1 (en) |
AT (1) | ATE133170T1 (en) |
AU (1) | AU628409B2 (en) |
CA (1) | CA1336715C (en) |
CY (1) | CY2026A (en) |
DE (2) | DE3836676A1 (en) |
DK (1) | DK175228B1 (en) |
ES (1) | ES2084593T3 (en) |
GR (1) | GR3018739T3 (en) |
HK (1) | HK1006167A1 (en) |
IE (1) | IE69982B1 (en) |
PT (1) | PT92145B (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
EP0508347A1 (en) * | 1991-04-10 | 1992-10-14 | Hoechst Aktiengesellschaft | 5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-(1-propyl)) piperidinyl]-4H-1-benzopyran-4-one, its preparation and its use |
US5464871A (en) * | 1993-05-12 | 1995-11-07 | Octamer, Inc. | Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents |
US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
DE59712561D1 (en) * | 1996-03-12 | 2006-04-13 | Sanofi Aventis Deutschland | Novel prodrugs for the treatment of tumors and inflammatory diseases |
DE19802449A1 (en) * | 1998-01-23 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Preparation of 3-hydroxy-1-methyl-4-phenyl-piperidine derivative isomer, for use as intermediate for antitumor agent flavopiridol |
DE19959546A1 (en) * | 1999-12-09 | 2001-06-21 | Rhone Poulenc Rorer Gmbh | Pharmaceutical preparation for the treatment of tumor diseases |
US6576647B2 (en) | 2000-01-18 | 2003-06-10 | Aventis Pharmaceuticals Inc. | Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one |
US6821990B2 (en) | 2000-01-18 | 2004-11-23 | Aventis Pharma Deutschland Gmbh | Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one |
SI1252155T1 (en) * | 2000-01-18 | 2005-06-30 | Aventis Pharmaceuticals Inc. | Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8- (4r-(3s-hydroxy-1-methyl)piperidinyl)-4h-1-benzopyran-4-one |
FR2805538B1 (en) * | 2000-02-29 | 2006-08-04 | Hoechst Marion Roussel Inc | NOVEL FLAVON DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE |
KR100392468B1 (en) * | 2000-09-18 | 2003-07-22 | 주식회사 엘지생명과학 | 3-Hydroxychromene-4-on derivatives useful as cyclin dependendent kinase inhibitors |
DE10113513A1 (en) * | 2001-03-20 | 2002-10-02 | Medinnova Ges Med Innovationen | Drug combination of kinase inhibitor and neurotropic factor, useful for treating and/or preventing nerve and/or glial cell damage, e.g. associated with neurodegenerative diseases |
US7547716B2 (en) | 2001-06-08 | 2009-06-16 | Institute Of Medicinal Molecular Design, Inc. | Sulfonamide derivatives |
RU2308454C9 (en) | 2002-04-17 | 2008-05-10 | Цитокинетикс, Инк. | Compounds, compositions based on the same and methods for using thereof |
TWI331034B (en) * | 2002-07-08 | 2010-10-01 | Piramal Life Sciences Ltd | Inhibitors of cyclin-dependent kinases and their use |
DE60326248D1 (en) | 2002-07-17 | 2009-04-02 | Cytokinetics Inc | Compounds, compositions and methods for treating cellular proliferative disorders |
EP2429292B1 (en) * | 2009-05-08 | 2019-04-03 | Georgia State University Research Foundation | Compounds and compositions comprising cdk inhibitors and their use in the treatment of cancer |
EP3399026A1 (en) | 2010-06-14 | 2018-11-07 | The Scripps Research Institute | Reprogramming of cells to a new fate |
WO2012007327A1 (en) | 2010-07-12 | 2012-01-19 | Dkfz Deutsches Krebsforschungszentrum | Wogonin for the prevention and therapy of cardiac hypertrophy |
WO2013113762A1 (en) | 2012-01-31 | 2013-08-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for predicting the risk of having a cutaneous melanoma in a subject |
US9901574B2 (en) | 2015-04-20 | 2018-02-27 | Tolero Pharmaceuticals, Inc. | Predicting response to alvocidib by mitochondrial profiling |
CN111349118B (en) | 2015-05-18 | 2023-08-22 | 住友制药肿瘤公司 | Avicenna prodrugs with increased bioavailability |
CA2993659A1 (en) | 2015-08-03 | 2017-02-09 | Tolero Pharmaceuticals, Inc. | Combination therapies for treatment of cancer |
US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | Treatment regimen for cancers that are insensitive to bcl-2 inhibitors using the mcl-1 inhibitor alvocidib |
US11034710B2 (en) | 2018-12-04 | 2021-06-15 | Sumitomo Dainippon Pharma Oncology, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
JP2022525149A (en) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド | Treatment of Acute Myeloid Leukemia (AML) with Venetoclax Failure |
CN110028475B (en) * | 2019-05-13 | 2022-07-01 | 中国药科大学 | Novel CDK9 inhibitor based on benzopyran structure, preparation method and application thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3329186A1 (en) * | 1983-08-12 | 1985-02-21 | Hoechst Ag, 6230 Frankfurt | CHROMONAL CALALIDE, METHOD FOR ITS INSULATION FROM DYSOXYLUM BINECTARIFERUM, AND ITS USE AS A MEDICINAL PRODUCT |
IN164232B (en) * | 1986-04-11 | 1989-02-04 | Hoechst India |
-
1988
- 1988-10-28 DE DE3836676A patent/DE3836676A1/en not_active Withdrawn
-
1989
- 1989-09-29 CA CA000614537A patent/CA1336715C/en not_active Expired - Lifetime
- 1989-10-24 AT AT89119710T patent/ATE133170T1/en not_active IP Right Cessation
- 1989-10-24 EP EP89119710A patent/EP0366061B1/en not_active Expired - Lifetime
- 1989-10-24 ES ES89119710T patent/ES2084593T3/en not_active Expired - Lifetime
- 1989-10-24 DE DE58909573T patent/DE58909573D1/en not_active Expired - Lifetime
- 1989-10-27 PT PT92145A patent/PT92145B/en not_active IP Right Cessation
- 1989-10-27 IE IE348189A patent/IE69982B1/en not_active IP Right Cessation
- 1989-10-27 KR KR1019890015509A patent/KR100194505B1/en not_active IP Right Cessation
- 1989-10-27 DK DK198905372A patent/DK175228B1/en not_active IP Right Cessation
- 1989-10-27 AU AU43841/89A patent/AU628409B2/en not_active Expired
- 1989-10-27 JP JP1278756A patent/JP2879910B2/en not_active Expired - Lifetime
-
1996
- 1996-01-19 GR GR960400124T patent/GR3018739T3/en unknown
-
1998
- 1998-02-20 CY CY202698A patent/CY2026A/en unknown
- 1998-06-12 HK HK98105251A patent/HK1006167A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU4384189A (en) | 1990-05-03 |
ATE133170T1 (en) | 1996-02-15 |
CY2026A (en) | 1998-02-20 |
DE3836676A1 (en) | 1990-05-03 |
HK1006167A1 (en) | 1999-02-12 |
JP2879910B2 (en) | 1999-04-05 |
EP0366061A1 (en) | 1990-05-02 |
DE58909573D1 (en) | 1996-02-29 |
DK175228B1 (en) | 2004-07-19 |
DK537289D0 (en) | 1989-10-27 |
KR100194505B1 (en) | 1999-06-15 |
CA1336715C (en) | 1995-08-15 |
JPH02178225A (en) | 1990-07-11 |
ES2084593T3 (en) | 1996-05-16 |
PT92145B (en) | 1995-06-30 |
EP0366061B1 (en) | 1996-01-17 |
PT92145A (en) | 1990-04-30 |
AU628409B2 (en) | 1992-09-17 |
KR900006325A (en) | 1990-05-07 |
IE69982B1 (en) | 1996-10-16 |
DK537289A (en) | 1990-04-29 |
GR3018739T3 (en) | 1996-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK9A | Patent expired |