IE801538L - Dithioacyldihydropyrazole carboxylic acid derivatives and¹dithioacylproline derivatives - Google Patents

Dithioacyldihydropyrazole carboxylic acid derivatives and¹dithioacylproline derivatives

Info

Publication number
IE801538L
IE801538L IE801538A IE153880A IE801538L IE 801538 L IE801538 L IE 801538L IE 801538 A IE801538 A IE 801538A IE 153880 A IE153880 A IE 153880A IE 801538 L IE801538 L IE 801538L
Authority
IE
Ireland
Prior art keywords
derivatives
dithioacyldihydropyrazole
carboxylic acid
acid derivatives
image
Prior art date
Application number
IE801538A
Other versions
IE50220B1 (en
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/061,729 external-priority patent/US4288368A/en
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Priority to IE237/80A priority Critical patent/IE50221B1/en
Priority to IE238/85A priority patent/IE50222B1/en
Publication of IE801538L publication Critical patent/IE801538L/en
Publication of IE50220B1 publication Critical patent/IE50220B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compounds of the formulae <IMAGE> and <IMAGE> in which the symbols have the definition given in Claim 1 possess a hypotensive action. [CH644102A5]
IE1538/80A 1979-07-30 1980-07-24 Dithioacyldihydropyrazole carboxylic acid derivatives dithioacylproline derivatives and related compounds IE50220B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IE237/80A IE50221B1 (en) 1979-07-30 1980-07-24 Iminothioacyldihydropyrazole carboxylic acid derivatives,imonothioacylproline derivatives and related compounds
IE238/85A IE50222B1 (en) 1979-07-30 1980-07-24 Substituted acyldihydropyrazole carboxylic acid derivatives,substituted acylproline derivatives and related compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/061,729 US4288368A (en) 1979-07-30 1979-07-30 Dithioacylproline derivatives

Publications (2)

Publication Number Publication Date
IE801538L true IE801538L (en) 1981-01-30
IE50220B1 IE50220B1 (en) 1986-03-05

Family

ID=22037741

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1538/80A IE50220B1 (en) 1979-07-30 1980-07-24 Dithioacyldihydropyrazole carboxylic acid derivatives dithioacylproline derivatives and related compounds

Country Status (6)

Country Link
AU (1) AU544054B2 (en)
CA (1) CA1155445A (en)
CH (1) CH644102A5 (en)
IE (1) IE50220B1 (en)
IT (1) IT1131778B (en)
ZA (1) ZA804152B (en)

Also Published As

Publication number Publication date
IT8023755A0 (en) 1980-07-28
CA1155445A (en) 1983-10-18
AU544054B2 (en) 1985-05-16
CH644102A5 (en) 1984-07-13
IT1131778B (en) 1986-06-25
ZA804152B (en) 1981-07-29
AU6036680A (en) 1981-02-05
IE50220B1 (en) 1986-03-05

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Legal Events

Date Code Title Description
MM4A Patent lapsed