IE780577L - Propanolamines - Google Patents
PropanolaminesInfo
- Publication number
- IE780577L IE780577L IE780577A IE57778A IE780577L IE 780577 L IE780577 L IE 780577L IE 780577 A IE780577 A IE 780577A IE 57778 A IE57778 A IE 57778A IE 780577 L IE780577 L IE 780577L
- Authority
- IE
- Ireland
- Prior art keywords
- carbon atoms
- alkyl
- hydrogen
- independently
- phenyl ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/38—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/93—Spiro compounds
- C07C2603/94—Spiro compounds containing "free" spiro atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of formula I wherein (i) m is o, n is 2 and p is 1 or (ii) m is o or 1, n is 1, and p is 1 or (iii) m is 1, n is 1 or 2 and p is o, R1 is (i) alkyl of 3 to 7 carbon atoms or (ii) phenylalkyl, phenoxyalkyl, phenylthioalkyl of 8 to 11 carbon atoms in the aggregate thereof and wherein the phenyl ring is separated by at least 2 carbon atoms from the nitrogen atoms to which R1 is bound and wherein the phenyl ring is unsubstituted, or mono-substituted by, or independently disubstituted by, alkyl or alkoxy of 1 to 4 carbon atoms, halogen of atomic number from 9 to 35. trifluoromethyl or cyano, R2 and R3 are either together straight chain alkylene of 4 to 6 carbon atoms. or, independently, hydrogen or alkyl of 1 to 4 carbon atoms, with the proviso that when m is 1, n is 1 and p is O then least one of R2 and R3 is other than hydrogen, and R4 and R5 are, independently, hydrogen or alkyl of 1 to 4 carbon atoms, are useful in the treatment of coronary disorders. (From CA1119190 A1) [FR2384740A1]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH375377A CH628021A5 (en) | 1977-03-24 | 1977-03-24 | Process for the preparation of 3-amino-2-hydroxypropoxy derivatives |
CH375177A CH633521A5 (en) | 1977-03-24 | 1977-03-24 | Process for preparing novel 3-amino-2-hydroxypropoxy derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
IE780577L true IE780577L (en) | 1978-09-24 |
IE46590B1 IE46590B1 (en) | 1983-07-27 |
Family
ID=25693765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE577/78A IE46590B1 (en) | 1977-03-24 | 1978-03-22 | Propanolamine derivatives |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS53149960A (en) |
AT (1) | AT370720B (en) |
AU (1) | AU521709B2 (en) |
CA (1) | CA1119190A (en) |
DE (1) | DE2810869A1 (en) |
DK (1) | DK117578A (en) |
ES (1) | ES468132A1 (en) |
FI (1) | FI780820A (en) |
FR (1) | FR2384740A1 (en) |
GB (1) | GB1597886A (en) |
IE (1) | IE46590B1 (en) |
IL (1) | IL54327A (en) |
IT (1) | IT1104178B (en) |
NL (1) | NL7802975A (en) |
NZ (1) | NZ186758A (en) |
PH (1) | PH13897A (en) |
PT (1) | PT67807A (en) |
SE (1) | SE7802972L (en) |
SU (1) | SU959622A3 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU516491B2 (en) * | 1978-11-06 | 1981-06-04 | Nippon Steel Corporation | Continuous casting |
FR2507181A1 (en) * | 1981-06-05 | 1982-12-10 | Sanofi Sa | NOVEL ETHERS OF PHENOL ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESS FOR PREPARING THEM AND USE THEREOF IN MEDICAMENTS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3641152A (en) * | 1968-09-23 | 1972-02-08 | Warner Lambert Pharmaceutical | 3 4-dihydronaphthalenoneoxy-2-hydroxy-propylamines |
CH621330A5 (en) * | 1976-05-14 | 1981-01-30 | Sandoz Ag |
-
1978
- 1978-03-13 DE DE19782810869 patent/DE2810869A1/en not_active Ceased
- 1978-03-15 FI FI780820A patent/FI780820A/en not_active Application Discontinuation
- 1978-03-15 SE SE7802972A patent/SE7802972L/en unknown
- 1978-03-15 DK DK117578A patent/DK117578A/en not_active Application Discontinuation
- 1978-03-20 NL NL7802975A patent/NL7802975A/en unknown
- 1978-03-21 GB GB1110/78A patent/GB1597886A/en not_active Expired
- 1978-03-21 FR FR7808108A patent/FR2384740A1/en active Granted
- 1978-03-22 ES ES468132A patent/ES468132A1/en not_active Expired
- 1978-03-22 AU AU34426/78A patent/AU521709B2/en not_active Expired
- 1978-03-22 IL IL54327A patent/IL54327A/en unknown
- 1978-03-22 PT PT67807A patent/PT67807A/en unknown
- 1978-03-22 PH PH20916A patent/PH13897A/en unknown
- 1978-03-22 IE IE577/78A patent/IE46590B1/en unknown
- 1978-03-22 NZ NZ186758A patent/NZ186758A/en unknown
- 1978-03-23 CA CA000299681A patent/CA1119190A/en not_active Expired
- 1978-03-23 AT AT0207178A patent/AT370720B/en not_active IP Right Cessation
- 1978-03-23 SU SU782594304A patent/SU959622A3/en active
- 1978-03-23 JP JP3246278A patent/JPS53149960A/en active Pending
- 1978-03-23 IT IT48558/78A patent/IT1104178B/en active
Also Published As
Publication number | Publication date |
---|---|
SU959622A3 (en) | 1982-09-15 |
ATA207178A (en) | 1982-09-15 |
CA1119190A (en) | 1982-03-02 |
PT67807A (en) | 1978-04-01 |
AU3442678A (en) | 1979-09-27 |
IT7848558A0 (en) | 1978-03-23 |
AU521709B2 (en) | 1982-04-29 |
IL54327A (en) | 1982-09-30 |
DK117578A (en) | 1978-09-25 |
JPS53149960A (en) | 1978-12-27 |
DE2810869A1 (en) | 1978-09-28 |
NL7802975A (en) | 1978-09-26 |
NZ186758A (en) | 1980-10-24 |
ES468132A1 (en) | 1979-07-01 |
IT1104178B (en) | 1985-10-21 |
GB1597886A (en) | 1981-09-16 |
AT370720B (en) | 1983-04-25 |
FI780820A (en) | 1978-09-25 |
IE46590B1 (en) | 1983-07-27 |
PH13897A (en) | 1980-10-27 |
IL54327A0 (en) | 1978-06-15 |
SE7802972L (en) | 1978-09-25 |
FR2384740A1 (en) | 1978-10-20 |
FR2384740B1 (en) | 1980-06-20 |
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