IE45905L - Substituted furan and thiophene alkyl ketones - Google Patents

Substituted furan and thiophene alkyl ketones

Info

Publication number
IE45905L
IE45905L IE772306A IE230677A IE45905L IE 45905 L IE45905 L IE 45905L IE 772306 A IE772306 A IE 772306A IE 230677 A IE230677 A IE 230677A IE 45905 L IE45905 L IE 45905L
Authority
IE
Ireland
Prior art keywords
carbon atoms
alkyl ketones
substituted furan
thiophene alkyl
bond
Prior art date
Application number
IE772306A
Other versions
IE45905B1 (en
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of IE45905L publication Critical patent/IE45905L/en
Publication of IE45905B1 publication Critical patent/IE45905B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compounds of the following general structure are useful as antirhinovirus agents: wherein Y Is a bond, oxygen or divalent sulfur; X is oxygen or sulfur; R is a straight or branched hydrocarbon chain having from 6 to 20 carbon atoms and is saturated or unsaturated having from 1 to 4 double bonds when R has from 10 to 20 carbon atoms and l or 2 double bonds when R has from 6 to 9 carbon atoms; and R, is hydrogen or a straight or branched alkyl group of from 1 to 4 carbon atoms; with the proviso that when Y is a bond the R-Y group is attached at the 4- or 5- position of the heterocycltc ring. [CA1104574A]
IE2306/77A 1976-12-20 1977-11-14 Substituted furan and thiophen alkyl ketones IE45905B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75113976A 1976-12-20 1976-12-20

Publications (2)

Publication Number Publication Date
IE45905L true IE45905L (en) 1978-06-20
IE45905B1 IE45905B1 (en) 1982-12-29

Family

ID=25020661

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2306/77A IE45905B1 (en) 1976-12-20 1977-11-14 Substituted furan and thiophen alkyl ketones

Country Status (15)

Country Link
JP (1) JPS5377055A (en)
AU (1) AU512654B2 (en)
BE (1) BE862066A (en)
CA (1) CA1104574A (en)
DE (1) DE2755750A1 (en)
DK (1) DK564977A (en)
ES (1) ES465093A1 (en)
FR (1) FR2374319A1 (en)
GB (1) GB1539636A (en)
IE (1) IE45905B1 (en)
IL (1) IL53386A0 (en)
NL (1) NL7713825A (en)
NZ (1) NZ185688A (en)
SE (1) SE436878B (en)
ZA (1) ZA776821B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0213066U (en) * 1988-07-12 1990-01-26
US4980371A (en) * 1988-12-21 1990-12-25 Merrell Dow Pharmaceuticals Antiretroviral furan ketones
AU621434B2 (en) * 1988-12-21 1992-03-12 Merrell Dow Pharmaceuticals Inc. Antiretroviral furan ketones
US4977185A (en) * 1988-12-21 1990-12-11 Merrell Dow Pharmaceuticals Antiretroviral aryloxy substituted furan ketones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2746973A (en) * 1955-05-27 1956-05-22 Du Pont 5-alkylmercapto-2-heterocyclic aldehydes and ketones
US4000164A (en) * 1973-04-02 1976-12-28 Richardson-Merrell Inc. Hypolipidemic agents

Also Published As

Publication number Publication date
ZA776821B (en) 1978-09-27
NL7713825A (en) 1978-06-22
CA1104574A (en) 1981-07-07
DK564977A (en) 1978-06-21
FR2374319B1 (en) 1980-10-17
JPS5377055A (en) 1978-07-08
IL53386A0 (en) 1978-01-31
AU512654B2 (en) 1980-10-23
FR2374319A1 (en) 1978-07-13
NZ185688A (en) 1980-09-12
SE7714210L (en) 1978-06-21
ES465093A1 (en) 1978-12-01
DE2755750A1 (en) 1978-06-22
BE862066A (en) 1978-04-14
GB1539636A (en) 1979-01-31
JPS622565B2 (en) 1987-01-20
SE436878B (en) 1985-01-28
IE45905B1 (en) 1982-12-29
AU3086777A (en) 1979-05-31

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Legal Events

Date Code Title Description
MM4A Patent lapsed