IE44403L - CIS-4a-PHENYL-ISOQUINOLINES - Google Patents

CIS-4a-PHENYL-ISOQUINOLINES

Info

Publication number
IE44403L
IE44403L IE762735A IE273576A IE44403L IE 44403 L IE44403 L IE 44403L IE 762735 A IE762735 A IE 762735A IE 273576 A IE273576 A IE 273576A IE 44403 L IE44403 L IE 44403L
Authority
IE
Ireland
Prior art keywords
hydrogen
carbon atoms
cis
isoquinolines
phenyl
Prior art date
Application number
IE762735A
Other versions
IE44403B1 (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1628375A external-priority patent/CH619937A5/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE44403L publication Critical patent/IE44403L/en
Publication of IE44403B1 publication Critical patent/IE44403B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Cis-4a-Phenylisoquinolines The compounds of formula I, I wherein (i) R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, R3 and R4 together are oxygen, and each of R5 and R6 is hydrogen, or (ii) R1 is hydrogen, alkyl of 1 to 4 carbon atoms, or alkanoyl of 1 to 4 carbon atoms, and R2 is an alkyl group of 1 to 4 carbon atoms, and (a) either R3 and R4, together, are oxygen, or methylene, and each of R5 and R6 is hydrogen, or (b) R3 and R6, together, form a bond, and each of R4 and R5 is hydrogen, are useful as analgesics, anti-depressants, tranquilizers and sleep inducers. [CA1085854A]
IE2735/76A 1975-12-16 1976-12-14 Cis-4a-phenyl-isoquinolines IE44403B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1628375A CH619937A5 (en) 1975-12-16 1975-12-16 Process for the preparation of novel cis-4a-phenyl- isoquinolines
CH1628475 1975-12-16

Publications (2)

Publication Number Publication Date
IE44403L true IE44403L (en) 1977-06-16
IE44403B1 IE44403B1 (en) 1981-11-18

Family

ID=25717645

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2735/76A IE44403B1 (en) 1975-12-16 1976-12-14 Cis-4a-phenyl-isoquinolines

Country Status (10)

Country Link
JP (1) JPS5273881A (en)
AU (1) AU512799B2 (en)
CA (1) CA1085854A (en)
DE (1) DE2655150A1 (en)
FR (1) FR2335225A1 (en)
GB (1) GB1568976A (en)
IE (1) IE44403B1 (en)
IL (1) IL51104A (en)
NZ (1) NZ182883A (en)
PH (1) PH13335A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2907461A1 (en) * 1978-03-10 1979-09-20 Sandoz Ag ISOCHINOLINE DERIVATIVES, THEIR MANUFACTURING AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE
EP0787721B1 (en) * 1995-07-20 1999-04-28 Toray Industries, Inc. 4a-ARYLDECAHYDROISOQUINOLINE COMPOUNDS AND MEDICINAL USES THEREOF
US5939551A (en) * 1996-05-15 1999-08-17 Toray Industries, Inc. Process for producing 4a-aryldecahydroisoquinoline derivatives
CN105473554B (en) 2013-07-10 2019-08-13 沃泰克斯药物股份有限公司 Condensed piperidine amide as ion channel modulators

Also Published As

Publication number Publication date
AU2062576A (en) 1978-06-22
IL51104A0 (en) 1977-02-28
IE44403B1 (en) 1981-11-18
GB1568976A (en) 1980-06-11
PH13335A (en) 1980-03-13
JPS5273881A (en) 1977-06-21
IL51104A (en) 1981-12-31
FR2335225A1 (en) 1977-07-15
DE2655150A1 (en) 1977-06-23
CA1085854A (en) 1980-09-16
AU512799B2 (en) 1980-10-30
NZ182883A (en) 1979-06-08
FR2335225B1 (en) 1980-04-18

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