IE43700L - 9-HYDROXYDIBENZO[b,d] PYRANS - Google Patents

9-HYDROXYDIBENZO[b,d] PYRANS

Info

Publication number
IE43700L
IE43700L IE761842A IE184276A IE43700L IE 43700 L IE43700 L IE 43700L IE 761842 A IE761842 A IE 761842A IE 184276 A IE184276 A IE 184276A IE 43700 L IE43700 L IE 43700L
Authority
IE
Ireland
Prior art keywords
formula
hydroxymethylene
substituent
hydroxydibenzo
pyrans
Prior art date
Application number
IE761842A
Other versions
IE43700B1 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IE43700L publication Critical patent/IE43700L/en
Publication of IE43700B1 publication Critical patent/IE43700B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/205Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
    • C07C43/2055Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The dibenzopyranones of formula III are prepared by condensation of a 4-(hydroxymethylene)chromanone of formula IV with methyl vinyl ketone. The substances of formula IV can be obtained by introduction of the hydroxymethylene substituent at position 3 by reaction of the corresponding compound not carrying this substituent with ethyl formate in the presence of sodium hydride. The compounds of formula III are particularly useful as intermediates in the synthesis of medicaments. <IMAGE> [CH622790A5]
IE1842/76A 1975-11-03 1976-08-19 9-hydroxydibenzo /b,d/pyrans and intermediates therefor IE43700B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62821075A 1975-11-03 1975-11-03

Publications (2)

Publication Number Publication Date
IE43700L true IE43700L (en) 1977-05-03
IE43700B1 IE43700B1 (en) 1981-05-06

Family

ID=24517939

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1842/76A IE43700B1 (en) 1975-11-03 1976-08-19 9-hydroxydibenzo /b,d/pyrans and intermediates therefor

Country Status (25)

Country Link
JP (3) JPS5277065A (en)
AR (1) AR220521A1 (en)
BG (3) BG28058A4 (en)
CA (1) CA1099269A (en)
CH (1) CH622790A5 (en)
CS (1) CS207571B2 (en)
DD (3) DD143774A5 (en)
DK (1) DK495876A (en)
EG (1) EG12648A (en)
ES (3) ES452772A1 (en)
FI (1) FI763131A (en)
GR (1) GR65202B (en)
HU (1) HU178321B (en)
IE (1) IE43700B1 (en)
IL (1) IL50717A (en)
NO (1) NO148745C (en)
NZ (1) NZ182368A (en)
PH (3) PH14811A (en)
PL (1) PL125297B1 (en)
PT (1) PT65781B (en)
RO (4) RO71411A (en)
SE (1) SE432251B (en)
SU (4) SU843748A3 (en)
YU (1) YU268176A (en)
ZA (1) ZA766281B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0765890A (en) * 1993-08-26 1995-03-10 Sumitomo Wiring Syst Ltd Connector
JP2988237B2 (en) * 1994-01-31 1999-12-13 住友電装株式会社 Simple waterproof connector
JP5037799B2 (en) * 2005-06-30 2012-10-03 パナソニック株式会社 TV outlet
CN215214680U (en) 2020-06-16 2021-12-17 爱信精机株式会社 Gear shifting device

Also Published As

Publication number Publication date
DD129214A5 (en) 1978-01-04
SU677660A3 (en) 1979-07-30
AR220521A1 (en) 1980-11-14
GR65202B (en) 1980-07-29
BG28057A4 (en) 1980-02-25
BG28058A4 (en) 1980-02-25
IL50717A0 (en) 1976-12-31
IE43700B1 (en) 1981-05-06
PH14811A (en) 1981-12-14
NO148745C (en) 1983-12-07
YU268176A (en) 1983-10-31
PT65781B (en) 1978-05-10
DD143774A5 (en) 1980-09-10
CA1099269A (en) 1981-04-14
RO76006A (en) 1981-03-30
SE432251B (en) 1984-03-26
RO71411A (en) 1982-12-06
PH16788A (en) 1984-02-28
SU784772A4 (en) 1980-11-30
RO75876A (en) 1981-05-30
IL50717A (en) 1981-09-13
PL193435A1 (en) 1980-01-28
DD137837A5 (en) 1979-09-26
PL125297B1 (en) 1983-04-30
SU677661A3 (en) 1979-07-30
BG27552A3 (en) 1979-11-12
NZ182368A (en) 1978-04-03
JPS5277065A (en) 1977-06-29
HU178321B (en) 1982-04-28
FI763131A (en) 1977-05-04
NO148745B (en) 1983-08-29
JPS56103173A (en) 1981-08-18
CS207571B2 (en) 1981-08-31
EG12648A (en) 1979-06-30
JPS5943958B2 (en) 1984-10-25
ZA766281B (en) 1977-09-28
SE7611275L (en) 1977-06-27
JPS5589280A (en) 1980-07-05
CH622790A5 (en) 1981-04-30
SU843748A3 (en) 1981-06-30
RO76124A (en) 1981-04-30
DK495876A (en) 1977-05-04
JPS5943955B2 (en) 1984-10-25
ES462783A1 (en) 1978-06-01
JPS564555B2 (en) 1981-01-30
NO763725L (en) 1977-05-04
ES452772A1 (en) 1978-02-16
PT65781A (en) 1976-12-01
PH14383A (en) 1981-06-24
ES462784A1 (en) 1978-06-01

Similar Documents

Publication Publication Date Title
IE45631L (en) 4-hydroxyphenylalkanolamine derivatives.
CA1035089A (en) Stabilised composition containing 2(2&#39;,2&#39;,6&#39;,6&#39;-tetramethylpiperidinyl-4&#39;) ethyl alcohol compounds
IE43700L (en) 9-HYDROXYDIBENZO[b,d] PYRANS
JPS52113974A (en) Synthesis of benzotriazole derivatives
JPS52113973A (en) Synthesis of benzotriazole derivatives
JPS572298A (en) Erythromycin derivative
JPS5432480A (en) Novel preparation of piperidine derivatives
IE42478L (en) Pharmaceutical composition
IE41394L (en) Benzimidazole derivatives
JPS5219642A (en) Preparation of 2-hydroxy-4-(2,7- alkadienyloxy)-benzophenones
SE8206352D0 (en) SET TO MAKE BENZYL ALCOHOL derivatives
JPS5432484A (en) Preparation of 5,8-dihydroxy-3,4-dihydro-carbostyril
JPS532476A (en) Synthesis of 4-substituted-dithio-2-azetidinone derivatives
JPS54119485A (en) Novel optically active pyridoxamine derivative and their preparation
JPS52105136A (en) Preparation of aminophenolalkylethers
JPS5562087A (en) Preparation of 1-(3-chloropropyl)-3, 7-dimethylxanthine
JPS52141839A (en) Preparation of royal purple compound
JPS52121700A (en) Preparation of novel photosensitive substances
JPS5257180A (en) Process for preparing l-ascorbic acid labeled with deuterium
JPS5223067A (en) Novel synthesis of 2-aminomethyl-1- ethylpyrrolidine
JPS57188538A (en) Preparations of ether derivatives of cyclopentenones
JPS5295636A (en) Preparation of oxime derivatives
JPS5753486A (en) Preparation of 3-formyl-pyrazolo 1,5-a pyridine derivative
JPS5212172A (en) Process for preparation of novel ortho- nitrobutyrophenone derivatives
ES422248A1 (en) Procedure for the preparation of 7-chlorine-1,2-dihydro-5-phenyl - 1,4-benzodiazepin-2-onas. (Machine-translation by Google Translate, not legally binding)