IE43222L - Piperazine derivatives - Google Patents

Piperazine derivatives

Info

Publication number
IE43222L
IE43222L IE72076A IE72076A IE43222L IE 43222 L IE43222 L IE 43222L IE 72076 A IE72076 A IE 72076A IE 72076 A IE72076 A IE 72076A IE 43222 L IE43222 L IE 43222L
Authority
IE
Ireland
Prior art keywords
hal
april
piperazine derivatives
novel compounds
gb1490507a
Prior art date
Application number
IE72076A
Other versions
IE43222B1 (en
Original Assignee
Parcor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parcor filed Critical Parcor
Publication of IE43222L publication Critical patent/IE43222L/en
Publication of IE43222B1 publication Critical patent/IE43222B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1490507 Piperazine derivatives PARCOR 6 April 1976 [7 April 1975] 13923/76 Heading C2C Novel compounds of formula where R 1 is halogen, alkyl, alkoxy or trifluoromethyl, and either R 2 and R 3 together complete a 4- to 8-membered saturated heterocyclic ring which may contain an oxygen or nitrogen atom as a second hetero atom, or R 2 is H and R 3 is cycloalkyl, and salts thereof, are prepared by reacting with B, wherein A is H and B is Hal(CH 2 ) 3 NR 2 R 3 or A is -(CH 2 ) 3 Hal and B is HNR 2 R 3 , or by condensing a cycloalkanone with an appropriate amine and reducing the resulting imine. Pharmaceutical compositions comprising the above novel compounds have hypocholesterolaemic, anti-inflammatory and analgesic activity. [GB1490507A]
IE72076A 1975-04-07 1976-04-06 Piperazine derivatives IE43222B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7510729A FR2306694A1 (en) 1975-04-07 1975-04-07 DERIVATIVES OF PIPERAZINE

Publications (2)

Publication Number Publication Date
IE43222L true IE43222L (en) 1976-10-07
IE43222B1 IE43222B1 (en) 1981-01-14

Family

ID=9153579

Family Applications (1)

Application Number Title Priority Date Filing Date
IE72076A IE43222B1 (en) 1975-04-07 1976-04-06 Piperazine derivatives

Country Status (10)

Country Link
JP (1) JPS51118780A (en)
BE (1) BE840326A (en)
DE (1) DE2609746A1 (en)
DK (1) DK140142B (en)
ES (1) ES446598A1 (en)
FR (1) FR2306694A1 (en)
GB (1) GB1490507A (en)
IE (1) IE43222B1 (en)
LU (1) LU74701A1 (en)
NL (1) NL7603508A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU532411B2 (en) * 1979-03-01 1983-09-29 Duphar International Research B.V. Phenyl piperazine derivatives
US4452798A (en) * 1982-06-22 1984-06-05 Warner-Lambert Company 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents
US4457931A (en) * 1982-09-27 1984-07-03 Selvi & C. S.P.A. Piperazine derivatives with anticholinergic and/or antihistaminic activity
CA2474214A1 (en) * 2002-02-05 2003-08-14 Novo Nordisk A/S Novel aryl- and heteroarylpiperazines
WO2007003604A2 (en) 2005-07-04 2007-01-11 Novo Nordisk A/S Hists1mine h3 receptor antagonists
EP2038256A1 (en) 2006-05-23 2009-03-25 TransTech Pharma, Inc 6- (4-cyclopropylpiperazin-1-yl) -2 ' -methyl- [3, 4 ']-bipyridine and its use as a medicament
US8378097B2 (en) 2006-05-29 2013-02-19 High Point Pharmaceuticals, Llc 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine H3 receptor antagonist
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists

Also Published As

Publication number Publication date
NL7603508A (en) 1976-10-11
DK140142C (en) 1979-11-19
IE43222B1 (en) 1981-01-14
FR2306694A1 (en) 1976-11-05
DK125476A (en) 1976-10-08
GB1490507A (en) 1977-11-02
BE840326A (en) 1976-10-04
DK140142B (en) 1979-06-25
FR2306694B1 (en) 1980-01-04
JPS51118780A (en) 1976-10-18
LU74701A1 (en) 1976-11-11
ES446598A1 (en) 1977-06-16
DE2609746A1 (en) 1976-10-14

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