IE39872L - 1, 3- oxygenated 8 ó- oestratrienes. - Google Patents
1, 3- oxygenated 8 ó- oestratrienes.Info
- Publication number
- IE39872L IE39872L IE741461A IE146174A IE39872L IE 39872 L IE39872 L IE 39872L IE 741461 A IE741461 A IE 741461A IE 146174 A IE146174 A IE 146174A IE 39872 L IE39872 L IE 39872L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- oestratrienes
- oxygenated
- oestraoligoene
- gb1479934a
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Abstract
1,3-Dihydroxy-1,3,5(10)-8alpha-oestratrienes or their ethers or esters of the following formula <IMAGE> in which the substituents are defined in Claim 1 are prepared. The said compounds are obtained by hydrogenating the 8(9) and, if present, the 14(15) double bond in a corresponding oestraoligoene. It is possible in the resulting compounds to reduce a 17-ketone group, to eliminate ester and ether groups, to esterify or etherify free hydroxyl groups and, furthermore, react a 17-ketone compound with organometallic compounds to introduce a hydrocarbon radical. The said compounds display favourable oestrogenic dissociation and they can be used for the treatment of manifestations of oestrogen deficiency.
[GB1479934A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2336431A DE2336431C2 (en) | 1973-07-13 | 1973-07-13 | 1.3-oxygenated 8-alpha-estratrienes, processes for their production and pharmaceuticals containing them |
| DE19742426777 DE2426777A1 (en) | 1974-05-31 | 1974-05-31 | 1,3-Oxygenated-8-alpha-oestratrienes for post-menopausal disorders - with vaginotropic, but low uterotrophic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39872L true IE39872L (en) | 1975-01-13 |
| IE39872B1 IE39872B1 (en) | 1979-01-17 |
Family
ID=25765510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1461/74A IE39872B1 (en) | 1973-07-13 | 1974-07-11 | 1 3-oxygenated 8a-oestratrienes |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS5821639B2 (en) |
| AT (1) | ATA575574A (en) |
| AU (1) | AU477010B2 (en) |
| CA (1) | CA1030951A (en) |
| CH (2) | CH609064A5 (en) |
| CS (2) | CS182300B2 (en) |
| DD (1) | DD114066A5 (en) |
| DK (1) | DK133051C (en) |
| ES (1) | ES428226A1 (en) |
| FI (1) | FI54131C (en) |
| FR (1) | FR2236505B1 (en) |
| GB (1) | GB1479934A (en) |
| HU (1) | HU169791B (en) |
| IE (1) | IE39872B1 (en) |
| IL (1) | IL45259A (en) |
| NO (1) | NO742546L (en) |
| SE (1) | SE7409151L (en) |
| SU (1) | SU626705A3 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2551214C2 (en) * | 1975-11-12 | 1984-07-12 | Schering AG, 1000 Berlin und 4709 Bergkamen | Process for the preparation of 1,3-oxygenated 8α-estatrienes |
| JPS5862734U (en) * | 1981-10-22 | 1983-04-27 | 日工株式会社 | formwork support sabot |
| JPS59146759A (en) * | 1984-01-06 | 1984-08-22 | 株式会社日立製作所 | Automatic screwing device |
| JPS60155376A (en) * | 1984-01-24 | 1985-08-15 | 松下電器産業株式会社 | Nut float detection apparatus |
| DE3710728A1 (en) * | 1987-03-31 | 1988-10-13 | Schering Ag | METHOD FOR PRODUCING 17 (ALPHA) -ETHINYL-17SS-HYDROXY-18-METHYL-4.15-ESTRADIEN-3-ON AND THE NEW INTERMEDIATE PRODUCTS FOR THIS METHOD |
| US6011024A (en) | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
| US6476011B1 (en) | 1991-08-28 | 2002-11-05 | Sterix Limited | Methods for introducing an estrogenic compound |
| US6903084B2 (en) | 1991-08-29 | 2005-06-07 | Sterix Limited | Steroid sulphatase inhibitors |
| US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
| GB0020498D0 (en) | 2000-08-18 | 2000-10-11 | Sterix Ltd | Compound |
| RU2679625C1 (en) * | 2018-11-08 | 2019-02-12 | Ильясов Шамиль Сионович | 3-o-sulfamoiloxy-6-oxa-7β-methyl-d-homo-8α-estra-1,3,5(10)-trien-17α-one application for the breast cancer treatment, including the triple negative form, and its production method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3436411A (en) * | 1967-12-28 | 1969-04-01 | American Home Prod | Process for cleaving an a-ring ether group in 13-alkylgona (and 8-isogona)-1,3,5(10)-trienes and delta-7-,delta-8(9)-,and delta-8(9),14(15)-dehydro derivatives thereof |
-
1974
- 1974-07-09 DK DK368074A patent/DK133051C/en not_active IP Right Cessation
- 1974-07-11 SE SE7409151A patent/SE7409151L/en unknown
- 1974-07-11 AT AT575574A patent/ATA575574A/en not_active Application Discontinuation
- 1974-07-11 DD DD179870A patent/DD114066A5/xx unknown
- 1974-07-11 IE IE1461/74A patent/IE39872B1/en unknown
- 1974-07-11 AU AU71123/74A patent/AU477010B2/en not_active Expired
- 1974-07-12 CS CS7600001694A patent/CS182300B2/en unknown
- 1974-07-12 SU SU742043783A patent/SU626705A3/en active
- 1974-07-12 ES ES428226A patent/ES428226A1/en not_active Expired
- 1974-07-12 CS CS7400004984A patent/CS182260B2/en unknown
- 1974-07-12 HU HU74@@E480A patent/HU169791B/en unknown
- 1974-07-12 JP JP49080116A patent/JPS5821639B2/en not_active Expired
- 1974-07-12 CH CH964674A patent/CH609064A5/en not_active IP Right Cessation
- 1974-07-12 CA CA204,667A patent/CA1030951A/en not_active Expired
- 1974-07-12 NO NO742546A patent/NO742546L/no unknown
- 1974-07-12 CH CH1035978A patent/CH614217A5/en not_active IP Right Cessation
- 1974-07-12 FI FI2139/74A patent/FI54131C/en active
- 1974-07-14 IL IL45259A patent/IL45259A/en unknown
- 1974-07-15 GB GB31241/74A patent/GB1479934A/en not_active Expired
- 1974-07-15 FR FR7424499A patent/FR2236505B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI54131C (en) | 1978-10-10 |
| IL45259A (en) | 1977-10-31 |
| ES428226A1 (en) | 1976-07-16 |
| CS182300B2 (en) | 1978-04-28 |
| FI213974A (en) | 1975-01-14 |
| CH609064A5 (en) | 1979-02-15 |
| FI54131B (en) | 1978-06-30 |
| SE7409151L (en) | 1975-01-14 |
| CH614217A5 (en) | 1979-11-15 |
| IE39872B1 (en) | 1979-01-17 |
| DK368074A (en) | 1975-03-17 |
| DK133051C (en) | 1976-08-16 |
| CS182260B2 (en) | 1978-04-28 |
| AU477010B2 (en) | 1976-10-14 |
| DK133051B (en) | 1976-03-15 |
| IL45259A0 (en) | 1974-10-22 |
| DD114066A5 (en) | 1975-07-12 |
| HU169791B (en) | 1977-01-28 |
| ATA575574A (en) | 1978-05-15 |
| CA1030951A (en) | 1978-05-09 |
| JPS5821639B2 (en) | 1983-05-02 |
| FR2236505B1 (en) | 1977-07-08 |
| GB1479934A (en) | 1977-07-13 |
| FR2236505A1 (en) | 1975-02-07 |
| SU626705A3 (en) | 1978-09-30 |
| AU7112374A (en) | 1976-01-15 |
| NO742546L (en) | 1975-02-10 |
| JPS5032160A (en) | 1975-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE39872B1 (en) | 1 3-oxygenated 8a-oestratrienes | |
| GB1476215A (en) | Dibenzoxepin derivatives process for the preparation thereof and pharmaceutical compositions containing them | |
| GB1530913A (en) | Copying materials | |
| GB1445956A (en) | Esters of dihydroapovincaminic acid | |
| GB1479362A (en) | 3,17,18-trihydroxy-1,3,5(10)-oestratrienes and their derivatives | |
| ES425088A1 (en) | Acidic oleo-acrylic resins and processes for preparing same | |
| GB1360164A (en) | 3,5-dialkyl-4-hydroxyphenylalkanoic acid esters of hydroxyalkyl hydroxyalkanoates | |
| GB1277264A (en) | 07-acetylgonanes and derivatives therefor | |
| JPS57206616A (en) | Menses inducer, feticidal or odynopoeia containing prostaglandin e1 analog | |
| GB1325943A (en) | Mono-acetyl derivatives of antibiotic sf 837 and sf 837-a2 substances and production thereof | |
| GB1476384A (en) | Liquid motor fuel compositions | |
| ES436218A1 (en) | Phenoxyalkanol derivatives and a process for their preparation | |
| GB1308849A (en) | Process for the preparation of 6alpha-methyl-19-nor-pregnenes | |
| ES400163A1 (en) | Novel pregnanoic acid derivatives | |
| GB1366664A (en) | 3 - /3 - cyanopropyl/ - cyclopenta /f/ /1/ benzopyrans and the preparation thereof | |
| GB1303008A (en) | ||
| GB1198146A (en) | 21-Ethers of 21-Hydroxy-delta<16>-Steroids of the Pregnane Series | |
| ES422841A1 (en) | 4-hydroxy-2,9-dioxatricyclo 4,3,1,0-3,7- decane esters | |
| GB1282703A (en) | Salicil derivatives, the preparation thereof and antiparasitic compositions containing them | |
| GB1435892A (en) | Aluminium complexes of guaiphenesin | |
| GB1260915A (en) | PROCESS FOR THE MANUFACTURE OF (ANDROST-17beta-YL)-alpha-PYRONES | |
| GB1415218A (en) | Oxabicyclononane and process for the manufacture htereof | |
| ES428829A1 (en) | A procedure for the preparation of an ester composition. (Machine-translation by Google Translate, not legally binding) | |
| ES318808A1 (en) | Procedure for the manufacture of new tertiary alcohols. (Machine-translation by Google Translate, not legally binding) | |
| GB1208039A (en) | 0-HYDROXY-7alpha-METHYL-OESTRADIOL DERIVATIVES |