IE34292B1 - 22-substituted cardenolide glycosides - Google Patents
22-substituted cardenolide glycosidesInfo
- Publication number
- IE34292B1 IE34292B1 IE749/70A IE74970A IE34292B1 IE 34292 B1 IE34292 B1 IE 34292B1 IE 749/70 A IE749/70 A IE 749/70A IE 74970 A IE74970 A IE 74970A IE 34292 B1 IE34292 B1 IE 34292B1
- Authority
- IE
- Ireland
- Prior art keywords
- group
- formula
- hydroxyl
- compounds
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
1320361 22-Substituted cardenolide glycosides DR KARL THOMAE GmbH 10 June 1970 [10 June 1969] 28196/70 Heading C2U [Also in Division C3] The invention comprises compounds of formula wherein R 1 is H, OH, acyloxy, 2<SP>1</SP>-tetrahydropyranyloxy or trimethylsiloxy; X is F, Cl, C 1-4 alkyl or C 1-4 alkoxy; and A is a group of formula wherein R 2 is H, acyl, 2<SP>1</SP>-tetrahydropyranyl or trimethylsilyl. Preparation thereof is by base-catalysed intramolecular cyclization of compounds of formula wherein R<SP>1</SP> 1 is H or protected hydroxy; X is as defined above; A<SP>1</SP> is a group as defined above for A wherein R 2 is a hydroxyl-protecting group; and R 3 is C 1-4 alkyl. When the resultant product contains a hydroxyl-protecting group other than acyl, 2<SP>1</SP>-tetrahydropyranyl or trimethylsilyl (e.g. benzyl), then said group must be removed to give a compound of Formula I. Removal of protecting groups in general may be effected by acid or base hydrolysis or by hydrogenolysis. A free hydroxyl group (R 1 or OR 2 ) in the product may thereafter be acylated. The starting materials are prepared as described in Specification 1,320,362. The inventive compounds are said to be cardioactive, and may be made up with carriers into pharmaceutical compositions for oral, rectal and parenteral administration.
[GB1320361A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19691929427 DE1929427C (en) | 1969-06-10 | 22 Fluorocardohd glycosides and medicinal products containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
IE34292L IE34292L (en) | 1970-12-19 |
IE34292B1 true IE34292B1 (en) | 1975-04-02 |
Family
ID=5736593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE749/70A IE34292B1 (en) | 1969-06-10 | 1970-06-09 | 22-substituted cardenolide glycosides |
Country Status (16)
Country | Link |
---|---|
AT (1) | AT300205B (en) |
BE (1) | BE751768A (en) |
BG (1) | BG17306A3 (en) |
CH (1) | CH549563A (en) |
DK (1) | DK128900B (en) |
ES (1) | ES380440A1 (en) |
FI (1) | FI47182C (en) |
FR (1) | FR2052944B1 (en) |
GB (2) | GB1320362A (en) |
IE (1) | IE34292B1 (en) |
IL (1) | IL34690A (en) |
NL (1) | NL7008408A (en) |
PL (1) | PL81115B1 (en) |
RO (1) | RO58404A (en) |
SE (1) | SE360357B (en) |
ZA (1) | ZA703907B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE788669A (en) * | 1971-09-11 | 1973-03-12 | Thomae Gmbh Dr K | NEW CARDENOLIDE-GLUCOSIDES |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1013910A (en) * | 1962-11-28 | 1965-12-22 | Manuf De Produits Pharmaoeutiq | New derivative of gitoxin, the use and preparation thereof |
CH459190A (en) * | 1965-02-01 | 1968-07-15 | Sandoz Ag | Process for the production of a new cardenolide |
-
1970
- 1970-06-04 BG BG14854A patent/BG17306A3/xx unknown
- 1970-06-05 ES ES380440A patent/ES380440A1/en not_active Expired
- 1970-06-05 RO RO63560A patent/RO58404A/ro unknown
- 1970-06-08 FI FI701616A patent/FI47182C/en active
- 1970-06-09 IL IL34690A patent/IL34690A/en unknown
- 1970-06-09 CH CH863270A patent/CH549563A/en not_active IP Right Cessation
- 1970-06-09 ZA ZA703907A patent/ZA703907B/en unknown
- 1970-06-09 DK DK298770AA patent/DK128900B/en unknown
- 1970-06-09 AT AT518170A patent/AT300205B/en not_active IP Right Cessation
- 1970-06-09 FR FR7021111A patent/FR2052944B1/fr not_active Expired
- 1970-06-09 PL PL1970141186A patent/PL81115B1/pl unknown
- 1970-06-09 IE IE749/70A patent/IE34292B1/en unknown
- 1970-06-10 GB GB5279472A patent/GB1320362A/en not_active Expired
- 1970-06-10 GB GB2819670A patent/GB1320361A/en not_active Expired
- 1970-06-10 SE SE08079/70A patent/SE360357B/xx unknown
- 1970-06-10 NL NL7008408A patent/NL7008408A/xx unknown
- 1970-06-10 BE BE751768D patent/BE751768A/en unknown
Also Published As
Publication number | Publication date |
---|---|
BG17306A3 (en) | 1973-07-25 |
RO58404A (en) | 1975-09-15 |
FR2052944A1 (en) | 1971-04-16 |
FR2052944B1 (en) | 1974-08-30 |
IL34690A0 (en) | 1970-08-19 |
GB1320361A (en) | 1973-06-13 |
FI47182C (en) | 1973-10-10 |
AT300205B (en) | 1972-07-25 |
DE1929427A1 (en) | 1971-01-07 |
CH549563A (en) | 1974-05-31 |
IE34292L (en) | 1970-12-19 |
ES380440A1 (en) | 1972-09-01 |
FI47182B (en) | 1973-07-02 |
BE751768A (en) | 1970-12-10 |
DK128900B (en) | 1974-07-22 |
SE360357B (en) | 1973-09-24 |
IL34690A (en) | 1974-06-30 |
GB1320362A (en) | 1973-06-13 |
NL7008408A (en) | 1970-12-14 |
PL81115B1 (en) | 1975-08-30 |
ZA703907B (en) | 1971-02-24 |
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