IE33541B1 - Heterocyclic benzamides - Google Patents
Heterocyclic benzamidesInfo
- Publication number
- IE33541B1 IE33541B1 IE1027/69A IE102769A IE33541B1 IE 33541 B1 IE33541 B1 IE 33541B1 IE 1027/69 A IE1027/69 A IE 1027/69A IE 102769 A IE102769 A IE 102769A IE 33541 B1 IE33541 B1 IE 33541B1
- Authority
- IE
- Ireland
- Prior art keywords
- methyl
- methoxy
- hydroxy
- prepared
- reacting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1,234,118. Substituted benzamides. SOC. D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE - DE - FRANCE. 28 July, 1969 [1 Aug., 1968; 29 Oct., 1968], No. 37797/69. Heading C2C. Novel substituted benzamides of the formula wherein A and R are allyl or C 1-5 alkyl, X is C 1-5 alkyl or OH, Y is halogen, m and n are 1 to 3 and acid addition and quaternary ammonium salts thereof are prepared by reacting the appropriate benzoic acid chlorides or esters with the corresponding heterocyclic amines. 2 - Methoxy - 4 - methyl - 5 - chlorobenzoyl chloride is obtained by reacting thionyl chloride with 2 - methoxy - 4 - methyl - 5 - chlorobenzoic acid, obtained by chlorinating and hydrolysing 2 - methoxy - 4 - methyl - 5 - chloroacetophenone, resulting from methylating 2 - hydroxy - 4 - methyl - 5 - chlorotoluene, which is prepared by treating 2 - chloro - 5 - acetoxytoluene with aluminium chloride. Methyl - 2 - methoxy - 4 - hydroxy - 5 - chlorobenzoate is made by chlorinating methyl - 2- methoxy - 4 - hydroxybenzoate, obtained by the hydrogenolysis of methyl - 2 - methoxy - 4 - benzyloxybenzoate, resulting from the methylation of methyl - 2 - hydroxy - 4 - benzyloxybenzoate, which is prepared by reacting methyl 2,4-dihydroxybenzoate with benzyl chloride. Pharmaceutical compositions, having antiemetic, spasmogenic and analgesic activity, contain the above novel compounds or pharmacologically acceptable acid addition or quaternary ammonium salts thereof and carriers. The compositions may be in the form of tablets, phials, suppositories, granules, syrups, sugar coat pills, solutions or aerosols.
[GB1234118A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR161593A FR7707M (en) | 1968-08-01 | 1968-08-01 | |
| FR171761 | 1968-10-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33541L IE33541L (en) | 1970-02-01 |
| IE33541B1 true IE33541B1 (en) | 1974-08-07 |
Family
ID=26182167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1027/69A IE33541B1 (en) | 1968-08-01 | 1969-07-24 | Heterocyclic benzamides |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS4837267B1 (en) |
| BE (1) | BE736560A (en) |
| BG (1) | BG17299A3 (en) |
| BR (1) | BR6911217D0 (en) |
| CA (1) | CA955949A (en) |
| CH (1) | CH507938A (en) |
| DE (2) | DE1937515C3 (en) |
| DK (1) | DK142844B (en) |
| ES (1) | ES369930A1 (en) |
| FI (1) | FI52214C (en) |
| GB (1) | GB1234118A (en) |
| IE (1) | IE33541B1 (en) |
| IL (1) | IL32712A (en) |
| LU (1) | LU59176A1 (en) |
| MC (1) | MC806A1 (en) |
| NL (1) | NL142410B (en) |
| NO (1) | NO131834C (en) |
| OA (1) | OA03889A (en) |
| PH (1) | PH11002A (en) |
| RO (1) | RO55778A (en) |
| SE (1) | SE359830B (en) |
| YU (1) | YU34289B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5212117U (en) * | 1975-07-15 | 1977-01-27 | ||
| IL52645A (en) * | 1976-08-05 | 1980-02-29 | Synthelabo | Optically active 1 substituted 2 aminomethyl pyrrolidines stereospecifics synthesis thereof and process for the preparation of optically active 2 methoxy n pyrrolidylmethyl benzamides |
| SE8101536L (en) * | 1981-03-11 | 1982-09-12 | Astra Laekemedel Ab | Benzamide derivative |
| SE8205135D0 (en) * | 1982-09-09 | 1982-09-09 | Astra Laekemedel Ab | Benzamido-DERIVATIVES |
-
1969
- 1969-07-21 CH CH1115769A patent/CH507938A/en not_active IP Right Cessation
- 1969-07-23 OA OA53680A patent/OA03889A/en unknown
- 1969-07-23 DE DE1937515A patent/DE1937515C3/en not_active Expired
- 1969-07-23 DE DE19691966215 patent/DE1966215A1/en not_active Withdrawn
- 1969-07-24 SE SE10434/69A patent/SE359830B/xx unknown
- 1969-07-24 IE IE1027/69A patent/IE33541B1/en unknown
- 1969-07-25 MC MC834A patent/MC806A1/en unknown
- 1969-07-25 BE BE736560D patent/BE736560A/xx not_active IP Right Cessation
- 1969-07-26 ES ES369930A patent/ES369930A1/en not_active Expired
- 1969-07-26 BG BG012749A patent/BG17299A3/en unknown
- 1969-07-27 IL IL32712A patent/IL32712A/en unknown
- 1969-07-28 LU LU59176D patent/LU59176A1/xx unknown
- 1969-07-28 GB GB1234118D patent/GB1234118A/en not_active Expired
- 1969-07-29 FI FI692247A patent/FI52214C/en active
- 1969-07-29 YU YU1965/69A patent/YU34289B/en unknown
- 1969-07-30 CA CA058,341*7A patent/CA955949A/en not_active Expired
- 1969-07-31 JP JP44060979A patent/JPS4837267B1/ja active Pending
- 1969-07-31 BR BR211217/69A patent/BR6911217D0/en unknown
- 1969-07-31 DK DK414169AA patent/DK142844B/en not_active IP Right Cessation
- 1969-07-31 NL NL696911713A patent/NL142410B/en not_active IP Right Cessation
- 1969-07-31 NO NO3148/69A patent/NO131834C/no unknown
- 1969-08-01 RO RO60706A patent/RO55778A/ro unknown
-
1973
- 1973-05-02 PH PH14575A patent/PH11002A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE359830B (en) | 1973-09-10 |
| MC806A1 (en) | 1970-07-30 |
| NL142410B (en) | 1974-06-17 |
| CA955949A (en) | 1974-10-08 |
| DE1937515C3 (en) | 1981-02-19 |
| BR6911217D0 (en) | 1973-02-15 |
| NL6911713A (en) | 1970-02-03 |
| FI52214B (en) | 1977-03-31 |
| IE33541L (en) | 1970-02-01 |
| ES369930A1 (en) | 1973-02-01 |
| PH11002A (en) | 1977-10-20 |
| RO55778A (en) | 1974-02-01 |
| GB1234118A (en) | 1971-06-03 |
| IL32712A0 (en) | 1969-09-25 |
| IL32712A (en) | 1973-06-29 |
| NO131834C (en) | 1975-08-13 |
| DE1966215A1 (en) | 1972-01-27 |
| LU59176A1 (en) | 1970-01-28 |
| DK142844C (en) | 1981-09-28 |
| NO131834B (en) | 1975-05-05 |
| OA03889A (en) | 1975-08-14 |
| DE1937515A1 (en) | 1970-07-02 |
| YU196569A (en) | 1978-10-31 |
| DK142844B (en) | 1981-02-09 |
| JPS4837267B1 (en) | 1973-11-09 |
| YU34289B (en) | 1979-04-30 |
| CH507938A (en) | 1971-05-31 |
| BG17299A3 (en) | 1973-07-25 |
| BE736560A (en) | 1970-01-26 |
| DE1937515B2 (en) | 1980-06-12 |
| FI52214C (en) | 1977-07-11 |
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