IE33283B1 - N-arallyl-n'-aralkyl piperazines and pharmaceutical compositions thereof - Google Patents
N-arallyl-n'-aralkyl piperazines and pharmaceutical compositions thereofInfo
- Publication number
- IE33283B1 IE33283B1 IE783/69A IE78369A IE33283B1 IE 33283 B1 IE33283 B1 IE 33283B1 IE 783/69 A IE783/69 A IE 783/69A IE 78369 A IE78369 A IE 78369A IE 33283 B1 IE33283 B1 IE 33283B1
- Authority
- IE
- Ireland
- Prior art keywords
- fluoro
- piperazine
- compound
- piperazines
- cinnamyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,268,710. Fluoro-substituted N-cinnamyl-N<SP>1</SP>- benzhydryl piperazine. JANSSEN PHARMACEUTICA N.V. 10 June 1969 [2 July, 1968], No. 29382/69. Heading C2C. Novel fluoro-substituted N-cinnamyl-N<SP>1</SP>- benzhydryl piperazines of the formula wherein each Ar may be a phenyl or fluorophenyl group, provided that at least one Ar is a fluorophenyl group, may be obtained by reacting a compound with a compound Y-CH 2 -CH=CH-Ar, where Y and Y<SP>1</SP> are different and represent a halogen atom or a piperazine residue, in the presence of a base and, if desired, forming a therapeutically active acid addition salt. Preparation of the following intermediates is also described: 1-(p-fluoro-α.-phenylbenzyl)-piperazine from p-fluoro-α-phenylbenzylchloride and piperazine; p-fluorocinnamylchloride from pfluoro-α-vinylbenzyl alcohol and HCl; di-(4- fluorophenyl)-chloromethane from α-(4-fluoro-phenyl)-4-fluorobenzyl alcohol and HCl. Pharmaceutical composition having anti-arrhythmic activity comprises a compound of Formula I above, or a therapeutically active acid addition salt thereof, in admixture with a pharmaceutically acceptable carrier, in forms suitable for oral or parenteral administration.
[GB1268710A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74199968A | 1968-07-02 | 1968-07-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33283L IE33283L (en) | 1970-01-02 |
| IE33283B1 true IE33283B1 (en) | 1974-05-15 |
Family
ID=24983099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE783/69A IE33283B1 (en) | 1968-07-02 | 1969-06-09 | N-arallyl-n'-aralkyl piperazines and pharmaceutical compositions thereof |
Country Status (20)
| Country | Link |
|---|---|
| AT (1) | AT289811B (en) |
| BE (1) | BE735452A (en) |
| BR (1) | BR6910304D0 (en) |
| CH (1) | CH510677A (en) |
| DE (1) | DE1929330C3 (en) |
| DK (1) | DK121175B (en) |
| ES (1) | ES368981A1 (en) |
| FI (1) | FI52979C (en) |
| FR (1) | FR2014487A1 (en) |
| GB (1) | GB1268710A (en) |
| IE (1) | IE33283B1 (en) |
| IL (1) | IL32520A (en) |
| LU (1) | LU58970A1 (en) |
| NL (1) | NL162646C (en) |
| NO (1) | NO124776B (en) |
| PL (1) | PL80098B1 (en) |
| SE (1) | SE350972B (en) |
| SU (1) | SU403182A3 (en) |
| YU (1) | YU36715B (en) |
| ZA (1) | ZA694714B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1213131B (en) * | 1984-02-02 | 1989-12-14 | Yason Srl | COMPOUND FOR PERIPHERAL ANTAGONIST, ANTICONVULSIVE AND EUMETABOLIC BRAIN ACTIVITY, METHOD FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS. |
-
1969
- 1969-06-09 IE IE783/69A patent/IE33283B1/en unknown
- 1969-06-10 DE DE1929330A patent/DE1929330C3/en not_active Expired
- 1969-06-10 GB GB29382/69A patent/GB1268710A/en not_active Expired
- 1969-06-13 CH CH911169A patent/CH510677A/en not_active IP Right Cessation
- 1969-06-26 SU SU1341578A patent/SU403182A3/ru active
- 1969-06-26 AT AT610669A patent/AT289811B/en not_active IP Right Cessation
- 1969-06-27 LU LU58970D patent/LU58970A1/xx unknown
- 1969-06-27 FR FR6921783A patent/FR2014487A1/fr active Pending
- 1969-06-30 YU YU1662/69A patent/YU36715B/en unknown
- 1969-06-30 SE SE09260/69*A patent/SE350972B/xx unknown
- 1969-06-30 NL NL6910007.A patent/NL162646C/en not_active IP Right Cessation
- 1969-06-30 BR BR210304/69A patent/BR6910304D0/en unknown
- 1969-06-30 ES ES368981A patent/ES368981A1/en not_active Expired
- 1969-07-01 BE BE735452D patent/BE735452A/xx not_active IP Right Cessation
- 1969-07-01 PL PL1969134557A patent/PL80098B1/pl unknown
- 1969-07-01 IL IL32520A patent/IL32520A/en unknown
- 1969-07-01 NO NO2753/69A patent/NO124776B/no unknown
- 1969-07-01 FI FI1956/69A patent/FI52979C/fi active
- 1969-07-02 DK DK357369AA patent/DK121175B/en unknown
- 1969-07-02 ZA ZA694714A patent/ZA694714B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK121175B (en) | 1971-09-20 |
| LU58970A1 (en) | 1969-11-12 |
| YU36715B (en) | 1984-08-31 |
| DE1929330B2 (en) | 1979-01-18 |
| ZA694714B (en) | 1971-02-24 |
| SU403182A3 (en) | 1973-10-19 |
| ES368981A1 (en) | 1971-05-16 |
| FI52979B (en) | 1977-09-30 |
| NO124776B (en) | 1972-06-05 |
| IE33283L (en) | 1970-01-02 |
| BR6910304D0 (en) | 1973-04-19 |
| IL32520A (en) | 1972-09-28 |
| DE1929330C3 (en) | 1979-09-13 |
| YU166269A (en) | 1982-02-25 |
| BE735452A (en) | 1970-01-02 |
| CH510677A (en) | 1971-07-31 |
| FI52979C (en) | 1978-01-10 |
| DE1929330A1 (en) | 1970-02-12 |
| PL80098B1 (en) | 1975-08-30 |
| SE350972B (en) | 1972-11-13 |
| GB1268710A (en) | 1972-03-29 |
| NL6910007A (en) | 1970-01-06 |
| FR2014487A1 (en) | 1970-04-17 |
| IL32520A0 (en) | 1969-09-25 |
| AT289811B (en) | 1971-05-10 |
| NL162646C (en) | 1980-06-16 |
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