IE33116L - Pyrryl-phenyl alkanoic acids - Google Patents

Pyrryl-phenyl alkanoic acids

Info

Publication number
IE33116L
IE33116L IE690577A IE57769A IE33116L IE 33116 L IE33116 L IE 33116L IE 690577 A IE690577 A IE 690577A IE 57769 A IE57769 A IE 57769A IE 33116 L IE33116 L IE 33116L
Authority
IE
Ireland
Prior art keywords
pyrryl
rch
acid
phenyl
compounds
Prior art date
Application number
IE690577A
Other versions
IE33116B1 (en
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of IE33116L publication Critical patent/IE33116L/en
Publication of IE33116B1 publication Critical patent/IE33116B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

1,264,367. 4 - [p - (1 - Pyrryl) phenyl] butyric and 3 - [p - (1 - pyrryl) benzoyl] propionic acids. J. R. GEIGY A.G. 28 April, 1969 [29 April, 1968; 20 Nov., 1968], No. 21523/69. Heading C2C. The invention comprises compounds of formula wherein Z is CH 2 or CO and R 1 is H, F or Cl, and their pharmaceutically acceptable salts. These compounds may be prepared by (1) reacting succinaldehyde or its derivative with a p-aminophenylbutyric or p-aminobenzoylpropionic acid; (2) decarboxylating the corresponding malonic acid; (3) hydrolysing the corresponding nitrile, alkyl ester or imido-ether; (4) reacting an alkyl 2 - acetyl - 4 - [p - (1 - pyrryl) phenyl] butyrate with alkali metal hydroxide (for Z = CH 2 ); (5) reducing the compound where Z = CO to that where Z = CH 2 . Details are given for the preparation of the following starting materials and intermediates: 4 - (4 - acetamino - 3 - chlorophenyl) butyric acid; ethyl 3-(p-aminophenyl) propionate; RCO 2 Et, RCH 2 OH, RCH 2 Cl, RCH 2 OTs-(p), RCH(CO 2 Et) 2 and BCH(CO 2 H) 2 [where R = p - (1 - pyrryl) phenethyl]; and R<SP>1</SP>CH(CO 2 Et) 2 , R<SP>1</SP>CH(CO 2 H) 2 and R<SP>1</SP>CH 2 CO 2 Et [where R<SP>1</SP>= 3 - chloro - 4 - (1 - pyrryl) phenethyl]. Also prepared is the 2,4-dinitrophenylhydrazone of 3-[p-(1-pyrryl) benzoyl] propionic acid. Therapeutic compositions for oral, rectal, local or parenteral administration comprise compounds of the above general formula, which have analgesic, antiphlogistic and antipyretic activity. [GB1264367A]
IE577/69A 1968-04-29 1969-04-28 Process for the production of new substituted phenylalkanoic acids IE33116B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH637968A CH500189A (en) 1968-04-29 1968-04-29 Process for the preparation of new, substituted phenylalkanoic acids
CH1732968A CH507234A (en) 1968-04-29 1968-11-20 Process for the production of new, substituted alkanoic acids

Publications (2)

Publication Number Publication Date
IE33116L true IE33116L (en) 1969-10-29
IE33116B1 IE33116B1 (en) 1974-03-20

Family

ID=25699490

Family Applications (1)

Application Number Title Priority Date Filing Date
IE577/69A IE33116B1 (en) 1968-04-29 1969-04-28 Process for the production of new substituted phenylalkanoic acids

Country Status (19)

Country Link
US (1) US3651084A (en)
JP (2) JPS4813550B1 (en)
AT (5) AT290517B (en)
BE (1) BE732301A (en)
BG (5) BG15206A3 (en)
CH (2) CH500189A (en)
CS (4) CS161854B2 (en)
DE (1) DE1921651A1 (en)
DK (1) DK125132C (en)
ES (4) ES366545A1 (en)
FI (1) FI50971C (en)
FR (1) FR2007555A1 (en)
GB (1) GB1264367A (en)
IE (1) IE33116B1 (en)
IL (1) IL32089A (en)
NL (1) NL6906209A (en)
NO (1) NO129572B (en)
PL (1) PL69906B1 (en)
SE (1) SE338994B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5834882A (en) * 1981-08-25 1983-03-01 Nitto Electric Ind Co Ltd Laminated adhesive tape for double-side bonding
JPS6183276A (en) * 1984-10-01 1986-04-26 Kimurashin Kk Double-sided adhesive tape
JPS6183275A (en) * 1984-10-01 1986-04-26 Kimurashin Kk Production of double-sided adhesive tape
JPS6198784A (en) * 1984-10-20 1986-05-17 Kimurashin Kk Double-coated adhesive tape
FI74723C (en) * 1986-10-24 1988-03-10 Yhtyneet Paperitehtaat Oy HAEFTPRODUKT.

Also Published As

Publication number Publication date
JPS4827309B1 (en) 1973-08-21
CS161852B2 (en) 1975-06-10
CS161854B2 (en) 1975-06-10
BG15548A3 (en) 1976-04-10
CH507234A (en) 1971-05-15
AT290519B (en) 1971-06-11
AT286976B (en) 1971-01-11
ES366545A1 (en) 1971-01-01
ES366546A1 (en) 1971-01-01
NO129572B (en) 1974-04-29
FI50971C (en) 1976-09-10
IL32089A (en) 1972-11-28
ES366544A1 (en) 1971-01-01
BG15206A3 (en) 1975-10-15
BG15547A3 (en) 1976-05-25
GB1264367A (en) 1972-02-23
AT290517B (en) 1971-06-11
IL32089A0 (en) 1969-06-25
DK125132C (en) 1973-07-02
BE732301A (en) 1969-10-29
FI50971B (en) 1976-05-31
ES366547A1 (en) 1971-01-01
US3651084A (en) 1972-03-21
IE33116B1 (en) 1974-03-20
AT290520B (en) 1971-06-11
JPS4813550B1 (en) 1973-04-27
PL69906B1 (en) 1973-10-31
CS161853B2 (en) 1975-06-10
DE1921651A1 (en) 1969-11-27
SE338994B (en) 1971-09-27
CS161851B2 (en) 1975-06-10
BG15752A3 (en) 1969-06-28
AT290518B (en) 1971-06-11
DK125132B (en) 1973-01-02
CH500189A (en) 1970-12-15
NL6906209A (en) 1969-10-31
FR2007555A1 (en) 1970-01-09
BG15546A3 (en) 1976-05-25

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