IE32705B1 - Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same - Google Patents
Novel alpha-carboline derivatives,the preparation thereof and compositions containing the sameInfo
- Publication number
- IE32705B1 IE32705B1 IE33869A IE33869A IE32705B1 IE 32705 B1 IE32705 B1 IE 32705B1 IE 33869 A IE33869 A IE 33869A IE 33869 A IE33869 A IE 33869A IE 32705 B1 IE32705 B1 IE 32705B1
- Authority
- IE
- Ireland
- Prior art keywords
- compositions
- substituted
- carboline
- araliphatic
- lotions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
1,268,772. Antiviral compositions. GLAXO LABORATORIES Ltd. 14 March, 1969 [15 March, 1968(2)], Nos. 12730/68 and 12731/68. Heading A5B. [Also in Division C2] Pharmaceutical or veterinary compositions having antiviral activity comprise, as active ingredient, at least one 2-substituted α-carboline of the general formula wherein R is a hydrogen atom or a substituted or unsubstituted aliphatic. araliphatic, aromatic or acyl group, X is a halogen atom or the residue of a nucleophile and wherein the nucleus is optionally additionally substituted by hydroxy, aliphatic, araliphatic, aromatic, carboxy, carboxylic acid ester, acylamino, amino, alkylamino, acyloxy, ether, nitro or sulphonic acid groups or halogen atoms, or physiologically compatible salt thereof, together with one or more pharmaceutical or veterinary carrier or excipient and/or other medicinal agents, e.g. anti-inflammatory agents such as steroids (e.g. betamethasone-21-phosphate) or antibiotics, such as tetracycline. The compositions may be administered orally, topically, rectally, intravaginally or parenterally in the form of tablets, capsules, lozenges, chewing gum, medicated sweets, solutions, suspensions, syrups, elixirs, emulsions, granules for constitution before use, liquid sprays, powder insufflations, nasal drops or ointments, throat paints, gargles, ophthalmic preparations and collyria, skin paints, lotions, creams, dusting powders, medicated dressings, eye drops and lotions, aerosols, suppositories, pessaries or injectable preparations. The compositions may also be formulated with a solid carrier or excipient or a sterile, pyrogen-free liquid or an aqueous oily liquid containing one or more suspending, dispersing, stabilising, preserving, solubilising, emulsifying or buffering agents. The compound 2-chloro-9-(3'-dimethylaminopiopyl) - α - carboline additionally shows neuroleptic activity.
[GB1268772A]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1273168A GB1268772A (en) | 1968-03-15 | 1968-03-15 | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
GB1273068 | 1968-03-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE32705L IE32705L (en) | 1969-09-15 |
IE32705B1 true IE32705B1 (en) | 1973-10-31 |
Family
ID=26249226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE33869A IE32705B1 (en) | 1968-03-15 | 1969-03-14 | Novel alpha-carboline derivatives,the preparation thereof and compositions containing the same |
Country Status (8)
Country | Link |
---|---|
AT (2) | AT304533B (en) |
BE (1) | BE729855A (en) |
CH (2) | CH553200A (en) |
DE (1) | DE1913119A1 (en) |
FR (1) | FR2003999A1 (en) |
GB (1) | GB1268772A (en) |
IE (1) | IE32705B1 (en) |
NL (1) | NL6903973A (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000286A (en) | 1975-05-28 | 1976-12-28 | Merck & Co., Inc. | 3-Phenyl,3H 1,2,3 triazolo[4,5-b]pyridines |
DK209976A (en) * | 1975-05-28 | 1976-11-29 | Merck & Co Inc | PROCEDURE FOR THE PREPARATION OF 3H-1,2,2-TRIAZOLE (4,5-B) PYRIDINES |
JPS5536401A (en) * | 1978-06-09 | 1980-03-14 | Japan Tobacco Inc | Amino-alpha-carboline compound and mutagenic agent containing the same |
FR2428642A1 (en) * | 1978-06-15 | 1980-01-11 | Sumitomo Chemical Co | Antitumour 7H-indolo:isoquinoline derivs. prepn. - by heating 2-isocyante-3-phenyl:indene deriv. unsubstituted at 1-posn. |
US4558132A (en) * | 1982-07-02 | 1985-12-10 | A. H. Robins Company, Incorporated | Nitro, amino and aroylamino-N-phenylpyridinamines in a process for preparing pyrido[1,4]benzodiazepines |
USRE37525E1 (en) | 1991-05-01 | 2002-01-22 | Henry M. Jackson Foundation | Method for treating infectious respiratory diseases |
DK0633886T3 (en) * | 1992-04-03 | 2000-12-18 | Upjohn Co | Pharmaceutically active bicyclic-heterocyclic amines |
US5502187A (en) * | 1992-04-03 | 1996-03-26 | The Upjohn Company | Pharmaceutically active bicyclic-heterocyclic amines |
US5369086A (en) * | 1993-04-28 | 1994-11-29 | Zeneca Limited | N-benzotriazoles |
US5696148A (en) * | 1994-03-14 | 1997-12-09 | Novo Nordisk A/S | Indole compounds and their use in treating diseases of the central nervous system |
US5783575A (en) * | 1994-03-14 | 1998-07-21 | Novo Nordisk A/S | Antagonists, their preparation and use |
JPH11509846A (en) * | 1995-07-31 | 1999-08-31 | ノボ ノルディスク アクティーゼルスカブ | Heterocyclic compounds, their preparation and use |
EP1248777A2 (en) * | 2000-01-07 | 2002-10-16 | Warner-Lambert Company | Tricyclic compounds with antiviral activity |
FR2823975B1 (en) * | 2001-04-27 | 2003-05-30 | Sanofi Synthelabo | NEW USE OF PYRIDOINDOLONE |
US7064139B2 (en) * | 2001-10-29 | 2006-06-20 | Uniroyal Chemical Company, Inc. | Method for treating retroviral infections |
US7456193B2 (en) | 2002-10-23 | 2008-11-25 | Sanofi-Aventis | Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics |
FR2846329B1 (en) | 2002-10-23 | 2004-12-03 | Sanofi Synthelabo | PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN -3 BY A PHENYL, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2869316B1 (en) * | 2004-04-21 | 2006-06-02 | Sanofi Synthelabo | PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN -6, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
FR2892416B1 (en) | 2005-10-20 | 2008-06-27 | Sanofi Aventis Sa | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF |
EP2161271A1 (en) * | 2008-09-08 | 2010-03-10 | Università Degli Studi Di Milano - Bicocca | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl |
CN113416187B (en) * | 2013-03-14 | 2024-07-19 | 奥斯菲治疗有限公司 | Alkylamine harmine derivatives for promoting bone growth |
US10662193B2 (en) | 2014-01-21 | 2020-05-26 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins |
CN112996506A (en) | 2018-08-14 | 2021-06-18 | 奥斯特克有限公司 | Pyrrolodipyridine compounds |
EP3837241A4 (en) | 2018-08-14 | 2022-05-18 | Osteoqc Inc. | FLUORO ß-CARBOLINE COMPOUNDS |
FR3109534B1 (en) | 2020-04-22 | 2022-03-25 | Soprema | Installation and process for processing composite products based on thermoplastic materials |
-
1968
- 1968-03-15 GB GB1273168A patent/GB1268772A/en not_active Expired
-
1969
- 1969-03-14 CH CH389969A patent/CH553200A/en not_active IP Right Cessation
- 1969-03-14 CH CH1271771A patent/CH561206A5/xx not_active IP Right Cessation
- 1969-03-14 AT AT253169A patent/AT304533B/en not_active IP Right Cessation
- 1969-03-14 AT AT736471A patent/AT310155B/en not_active IP Right Cessation
- 1969-03-14 DE DE19691913119 patent/DE1913119A1/en active Pending
- 1969-03-14 FR FR6907280A patent/FR2003999A1/fr not_active Withdrawn
- 1969-03-14 IE IE33869A patent/IE32705B1/en unknown
- 1969-03-14 NL NL6903973A patent/NL6903973A/xx unknown
- 1969-03-14 BE BE729855D patent/BE729855A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AT304533B (en) | 1973-01-10 |
CH553200A (en) | 1974-08-30 |
FR2003999A1 (en) | 1969-11-14 |
DE1913119A1 (en) | 1970-08-06 |
CH561206A5 (en) | 1975-04-30 |
GB1268772A (en) | 1972-03-29 |
NL6903973A (en) | 1969-09-17 |
IE32705L (en) | 1969-09-15 |
AT310155B (en) | 1973-09-25 |
BE729855A (en) | 1969-09-15 |
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