IE32504B1 - Benzodiazepine derivatives - Google Patents

Benzodiazepine derivatives

Info

Publication number
IE32504B1
IE32504B1 IE1425/68A IE142568A IE32504B1 IE 32504 B1 IE32504 B1 IE 32504B1 IE 1425/68 A IE1425/68 A IE 1425/68A IE 142568 A IE142568 A IE 142568A IE 32504 B1 IE32504 B1 IE 32504B1
Authority
IE
Ireland
Prior art keywords
alkyl
hal
benzodiazepine derivatives
phch2
subst
Prior art date
Application number
IE1425/68A
Other versions
IE32504L (en
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of IE32504L publication Critical patent/IE32504L/en
Publication of IE32504B1 publication Critical patent/IE32504B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compds. of general formula (I). R' = H, (1-4C) alkyl, or PhCH2. R2 = (1-4C) alkyl, (1-3C) alkyl subst. by MeO or EtO, allyl, or PhCH2 opt. subst. by hal or (1-2C) alkyl. R3 = H, hal., (1-2C) alkyl, or (1-2C) O-alkyl. R4 = H, hal., OH, NO2, NH2, CN, (1-2C) alkyl, or (1-2C) O alkyl. R5 = H, hal., CF3, (1-2C) alkyl, (1-2C) Alkyl. R6 = H, hal., or (1-2C) alkyl. Psychosedatives and anti-convulsants. Dose 1-100 mg. [DE1810423B2]
IE1425/68A 1967-11-24 1968-11-22 Benzodiazepine derivatives IE32504B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT1064767A AT280290B (en) 1967-11-24 1967-11-24 Process for the preparation of new 1-phenyl-4-alkyl-3H-1,4-benzodiazepine-2,5- [1H, 4H] -diones

Publications (2)

Publication Number Publication Date
IE32504L IE32504L (en) 1969-05-24
IE32504B1 true IE32504B1 (en) 1973-08-22

Family

ID=3623762

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1425/68A IE32504B1 (en) 1967-11-24 1968-11-22 Benzodiazepine derivatives

Country Status (13)

Country Link
AT (1) AT280290B (en)
BE (1) BE724364A (en)
BR (1) BR6804236D0 (en)
CH (1) CH523265A (en)
DE (1) DE1810423B2 (en)
DK (1) DK124950B (en)
ES (2) ES360410A1 (en)
FR (2) FR1593335A (en)
GB (1) GB1173540A (en)
IE (1) IE32504B1 (en)
IL (1) IL31146A (en)
NL (1) NL6815755A (en)
SE (1) SE356979B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914216A (en) * 1962-12-18 1975-10-21 Boehringer Sohn Ingelheim 1-Phenyl-3H-1,4-benzodiazepine-2,5-(1H,4H)-diones
DE2117438A1 (en) * 1971-04-08 1972-10-19 CH. Boehringer Sohn, 6507 Ingelheim New substituted 1,3-dihydro-2H-1 ^ -benzodiazepine ^ -ones
BE793460A (en) * 1971-12-29 1973-06-28 Boehringer Sohn Ingelheim NEWS 1-ARYL-3H, 1,4-BENZODIAZEPINE-2,5- (1H
US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
DE60007960T2 (en) * 1999-04-30 2004-10-21 Univ Michigan Ann Arbor Therapeutic applications of pro-apoptotic benzodiazepines
US7572788B2 (en) 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7276348B2 (en) 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
US7691582B2 (en) 2002-09-27 2010-04-06 The Regents Of The University Of Michigan Methods of secretory vimentin detection and modulation
AU2006203946B2 (en) 2005-01-03 2009-07-23 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
JP2008545757A (en) 2005-06-01 2008-12-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Unsolvated benzodiazepine compositions and methods
AU2006308655B2 (en) 2005-11-01 2010-09-23 The Regents Of The University Of Michigan Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
US7759338B2 (en) 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
WO2007146167A1 (en) 2006-06-09 2007-12-21 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
CA2783589A1 (en) 2007-03-09 2008-09-18 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
JP2010526825A (en) 2007-05-10 2010-08-05 エーエムアール テクノロジー インコーポレイテッド Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and their use to block reuptake of norepinephrine, dopamine and serotonin
EP2200977B1 (en) 2007-09-14 2016-11-09 The Regents of the University of Michigan F1f0-atpase inhibitors and related methods
CN101918375A (en) 2007-11-06 2010-12-15 密歇根大学董事会 Benzodiazepinone compounds useful in the treatment of skin conditions
AU2009291632B2 (en) 2008-09-11 2013-04-04 The Regents Of The University Of Michigan Aryl guanidine F1F0-ATPase inhibitors and related methods
WO2010121164A2 (en) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
JP2013505258A (en) 2009-09-18 2013-02-14 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Benzodiazepinone compounds and therapeutic methods using the same
US8815845B2 (en) 2009-11-17 2014-08-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
WO2011062765A2 (en) 2009-11-17 2011-05-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
JP6863742B2 (en) * 2013-09-11 2021-04-21 ジ・アドミニストレーターズ・オブ・ザ・チューレーン・エデュケーショナル・ファンド New anthranilamide and its use

Also Published As

Publication number Publication date
DE1810423C3 (en) 1973-10-11
DE1810423B2 (en) 1973-03-22
ES378977A1 (en) 1973-01-16
GB1173540A (en) 1969-12-10
ES360410A1 (en) 1970-11-01
SE356979B (en) 1973-06-12
BE724364A (en) 1969-05-22
IE32504L (en) 1969-05-24
FR1593335A (en) 1970-05-25
FR8310M (en) 1970-11-23
NL6815755A (en) 1969-05-28
DK124950B (en) 1972-12-11
IL31146A (en) 1972-04-27
IL31146A0 (en) 1969-01-29
BR6804236D0 (en) 1973-02-08
DE1810423A1 (en) 1969-10-09
AT280290B (en) 1970-04-10
CH523265A (en) 1972-05-31

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