IE32021B1 - Benzothioxanthene derivatives,their preparation and compositions containing them - Google Patents

Benzothioxanthene derivatives,their preparation and compositions containing them

Info

Publication number
IE32021B1
IE32021B1 IE434/68A IE43468A IE32021B1 IE 32021 B1 IE32021 B1 IE 32021B1 IE 434/68 A IE434/68 A IE 434/68A IE 43468 A IE43468 A IE 43468A IE 32021 B1 IE32021 B1 IE 32021B1
Authority
IE
Ireland
Prior art keywords
general formula
benzothioxanthene
derivative
formula above
reaction
Prior art date
Application number
IE434/68A
Other versions
IE32021L (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IE32021L publication Critical patent/IE32021L/en
Publication of IE32021B1 publication Critical patent/IE32021B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,191,384. Benzothioxanthene derivatives. MERCK & CO. Inc. 24 April, 1968 [27 April, 1967], No. 19394/68. Heading C2C. Novel benzothioxanthene derivatives of the general formulµ wherein B is a benzene ring fused in the [a] or [c] position, X is a chlorine or bromine atom attached to the left-hand ring and each R is a hydrogen atom or a C 1-6 alkyl group, and non- toxic acid addition salts thereof are prepared (a) by reaction of a hydroxybenzothioxanthene derivative of the general formula with phosphorus and hydrogen iodide; (b) by reaction of a benzothioxanthene derivative of the second general formula above with phosphorus and hydrogen iodide; (c) by catalytic hydrogenation of a benzothioxanthene derivative of the second general formula above, in each case producing a benzothioxanthene derivative of the first general formula above; or (d) by reaction of a hydroxy-benzothioxanthene derivative of the third general formula above with an acidic dehydrating agent to produce a benzothioxanthene derivative of the second general formula above; followed optionally by salification of the product. Pharmaceutical compositions having local anaesthetic activity comprise a non-toxic acid addition salt of a benzothioxanthene derivative of the first or second general formula above in sterile aqueous solution and may be administered by injection. [GB1191384A]
IE434/68A 1967-04-27 1968-04-17 Benzothioxanthene derivatives,their preparation and compositions containing them IE32021B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63412367A 1967-04-27 1967-04-27

Publications (2)

Publication Number Publication Date
IE32021L IE32021L (en) 1968-10-27
IE32021B1 true IE32021B1 (en) 1973-03-21

Family

ID=24542527

Family Applications (1)

Application Number Title Priority Date Filing Date
IE434/68A IE32021B1 (en) 1967-04-27 1968-04-17 Benzothioxanthene derivatives,their preparation and compositions containing them

Country Status (7)

Country Link
BE (1) BE714011A (en)
DE (1) DE1768300A1 (en)
FR (2) FR1589420A (en)
GB (2) GB1191385A (en)
IE (1) IE32021B1 (en)
IL (1) IL29823A (en)
NL (1) NL6805112A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073912A (en) * 1976-10-12 1978-02-14 Smithkline Corporation Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof
US4234643A (en) * 1978-05-30 1980-11-18 The Meyercord Co. Tennis ball marking decalcomania

Also Published As

Publication number Publication date
IE32021L (en) 1968-10-27
FR1589420A (en) 1970-03-31
IL29823A0 (en) 1968-06-20
NL6805112A (en) 1968-10-28
FR7942M (en) 1970-05-25
DE1768300A1 (en) 1971-11-18
GB1191384A (en) 1970-05-13
BE714011A (en) 1968-10-22
IL29823A (en) 1972-07-26
GB1191385A (en) 1970-05-13

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