HUT76481A - 3,5-disubstituted and 3,4,5-trisubstituted 2-isoxazolines and isoxazoles, process for preparating the same and pharmaceutical compositions containing the same - Google Patents
3,5-disubstituted and 3,4,5-trisubstituted 2-isoxazolines and isoxazoles, process for preparating the same and pharmaceutical compositions containing the sameInfo
- Publication number
- HUT76481A HUT76481A HU9602458A HU9602458A HUT76481A HU T76481 A HUT76481 A HU T76481A HU 9602458 A HU9602458 A HU 9602458A HU 9602458 A HU9602458 A HU 9602458A HU T76481 A HUT76481 A HU T76481A
- Authority
- HU
- Hungary
- Prior art keywords
- same
- pct
- formula
- isoxazolines
- preparating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
- C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4408084A DE4408084A1 (de) | 1994-03-10 | 1994-03-10 | 3,5-Disubstituierte und 3,4,5-trisubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
PCT/EP1995/000784 WO1995024397A1 (de) | 1994-03-10 | 1995-03-03 | 3,5-disubstituierte und 3,4,5-trisubstituierte 2-isoxazoline und isoxazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9602458D0 HU9602458D0 (en) | 1996-11-28 |
HUT76481A true HUT76481A (en) | 1997-09-29 |
HU225499B1 HU225499B1 (en) | 2007-01-29 |
Family
ID=6512412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9602458A HU225499B1 (en) | 1994-03-10 | 1995-03-03 | 3,5-disubstituted and 3,4,5-trisubstituted 2-isoxazolines and isoxazoles, process for preparating the same and pharmaceutical compositions containing the same |
Country Status (17)
Country | Link |
---|---|
US (1) | US5814627A (hu) |
EP (1) | EP0749429B1 (hu) |
JP (1) | JPH09509951A (hu) |
KR (1) | KR100330798B1 (hu) |
CN (1) | CN1056836C (hu) |
AT (1) | ATE181733T1 (hu) |
AU (1) | AU684914B2 (hu) |
CA (1) | CA2185004A1 (hu) |
DE (2) | DE4408084A1 (hu) |
DK (1) | DK0749429T3 (hu) |
ES (1) | ES2135046T3 (hu) |
FI (1) | FI963508A0 (hu) |
GR (1) | GR3031266T3 (hu) |
HU (1) | HU225499B1 (hu) |
NO (1) | NO306723B1 (hu) |
TW (1) | TW419469B (hu) |
WO (1) | WO1995024397A1 (hu) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5510361A (en) * | 1994-10-20 | 1996-04-23 | The Procter & Gamble Company | Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents |
AR029304A1 (es) * | 1998-06-26 | 2003-06-25 | Daiichi Seiyaku Co | DERIVADOS DE PROPIONILO SUSTITUIDOS, PRODUCTO FARMACEUTICO, USO PARA LA FABRICACION DE UNA COMPOSICION FARMACEUTICA PARA LA PREVENCION Y/O TRATAMIENTO DE HIPERCOLESTEROLEMIA, HIPERLIPEMIA O ARTERIOESCLEROSIS, COMPOSICIoN FARMACÉUTICA Y COMPUESTOS INTERMEDIARIOS |
USRE39708E1 (en) | 1998-08-07 | 2007-06-26 | Chiron Corporation | Estrogen receptor modulators |
ES2255294T3 (es) | 1998-08-07 | 2006-06-16 | Chiron Corporation | Derivados de isoxazol sustituidos como moduladores del receptor de estrogenos. |
EP1102753B1 (en) | 1998-08-07 | 2007-02-28 | Novartis Vaccines and Diagnostics, Inc. | Pyrazoles as estrogen receptor modulators |
ES2216579T3 (es) | 1998-10-09 | 2004-10-16 | Janssen Pharmaceutica N.V. | Derivados de 4,5-dihidro-isoxazol y su uso farmaceutico. |
PL366110A1 (en) * | 1999-08-13 | 2005-01-24 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
US6579880B2 (en) | 2000-06-06 | 2003-06-17 | Ortho-Mcneil Pharmaceutical, Inc. | Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8 |
US7022725B2 (en) | 2000-11-17 | 2006-04-04 | Takeda Pharmaceutical Company Limited | Isoxazole derivatives |
MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
WO2004018463A2 (en) * | 2002-08-23 | 2004-03-04 | Rigel Pharmaceuticals, Inc. | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
WO2004099165A2 (en) * | 2003-05-02 | 2004-11-18 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds and hydro isomers thereof |
US7115642B2 (en) | 2003-05-02 | 2006-10-03 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection |
US7220745B2 (en) * | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
WO2005034952A2 (en) * | 2003-10-07 | 2005-04-21 | The Feinstein Institute For Medical Research | Isoxazole and isothiazole compounds useful in the treatment of inflammation |
US7410979B2 (en) * | 2003-11-19 | 2008-08-12 | Rigel Pharmaceuticals, Inc. | Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections |
US7514434B2 (en) | 2004-02-23 | 2009-04-07 | Rigel Pharmaceuticals, Inc. | Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof |
ES2526614T3 (es) | 2004-03-05 | 2015-01-13 | Nissan Chemical Industries, Ltd. | Compuesto de benzamida sustituida con isoxazolina y agente de control de organismos nocivos |
WO2005097760A1 (en) * | 2004-03-26 | 2005-10-20 | Rigel Pharmaceuticals, Inc. | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
JP2008540425A (ja) * | 2005-05-02 | 2008-11-20 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 代謝可能部分を含む複素環式抗ウイルス性化合物およびその使用 |
DK2921492T3 (en) * | 2011-12-27 | 2017-12-11 | Bayer Ip Gmbh | HETEROARYLPIPERIDINE AND ¿PIPERAZINE DERIVATIVES |
EP2943514B1 (en) | 2013-01-14 | 2019-06-05 | Kraton Polymers U.S. LLC | Anion exchange block copolymers, their manufacture and their use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58148858A (ja) * | 1982-02-26 | 1983-09-05 | Yamanouchi Pharmaceut Co Ltd | 3,5−ジ−tert−ブチル−4−ヒドロキシフエニル置換複素環化合物 |
IE59813B1 (en) * | 1986-05-09 | 1994-04-06 | Warner Lambert Co | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them |
US5086064A (en) * | 1990-03-27 | 1992-02-04 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl thiazolyl, oxazolyl, and imidazolyl methanones and related compounds as antiinflammatory agents |
US5510361A (en) * | 1994-10-20 | 1996-04-23 | The Procter & Gamble Company | Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents |
-
1994
- 1994-03-10 DE DE4408084A patent/DE4408084A1/de not_active Withdrawn
- 1994-09-16 TW TW83108551A patent/TW419469B/zh active
-
1995
- 1995-03-03 DE DE59506310T patent/DE59506310D1/de not_active Expired - Lifetime
- 1995-03-03 AT AT95912197T patent/ATE181733T1/de not_active IP Right Cessation
- 1995-03-03 JP JP7523212A patent/JPH09509951A/ja not_active Ceased
- 1995-03-03 EP EP95912197A patent/EP0749429B1/de not_active Expired - Lifetime
- 1995-03-03 CA CA002185004A patent/CA2185004A1/en not_active Abandoned
- 1995-03-03 DK DK95912197T patent/DK0749429T3/da active
- 1995-03-03 HU HU9602458A patent/HU225499B1/hu not_active IP Right Cessation
- 1995-03-03 KR KR1019960704985A patent/KR100330798B1/ko not_active IP Right Cessation
- 1995-03-03 CN CN95192004A patent/CN1056836C/zh not_active Expired - Fee Related
- 1995-03-03 AU AU19481/95A patent/AU684914B2/en not_active Ceased
- 1995-03-03 US US08/704,743 patent/US5814627A/en not_active Expired - Lifetime
- 1995-03-03 ES ES95912197T patent/ES2135046T3/es not_active Expired - Lifetime
- 1995-03-03 WO PCT/EP1995/000784 patent/WO1995024397A1/de active IP Right Grant
-
1996
- 1996-08-26 NO NO963560A patent/NO306723B1/no unknown
- 1996-09-06 FI FI963508A patent/FI963508A0/fi not_active IP Right Cessation
-
1999
- 1999-09-22 GR GR990402364T patent/GR3031266T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CN1056836C (zh) | 2000-09-27 |
CN1143956A (zh) | 1997-02-26 |
JPH09509951A (ja) | 1997-10-07 |
EP0749429B1 (de) | 1999-06-30 |
FI963508A (fi) | 1996-09-06 |
NO963560L (no) | 1996-08-26 |
FI963508A0 (fi) | 1996-09-06 |
ES2135046T3 (es) | 1999-10-16 |
US5814627A (en) | 1998-09-29 |
CA2185004A1 (en) | 1995-09-14 |
NO306723B1 (no) | 1999-12-13 |
DK0749429T3 (da) | 2000-01-10 |
DE4408084A1 (de) | 1995-09-14 |
KR970701703A (ko) | 1997-04-12 |
KR100330798B1 (ko) | 2002-10-11 |
WO1995024397A1 (de) | 1995-09-14 |
AU1948195A (en) | 1995-09-25 |
HU9602458D0 (en) | 1996-11-28 |
EP0749429A1 (de) | 1996-12-27 |
DE59506310D1 (de) | 1999-08-05 |
HU225499B1 (en) | 2007-01-29 |
ATE181733T1 (de) | 1999-07-15 |
AU684914B2 (en) | 1998-01-08 |
GR3031266T3 (en) | 1999-12-31 |
TW419469B (en) | 2001-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of definitive patent protection due to non-payment of fees |