HUT53593A - Process for producing optically active n-(terc butoxy-carbonyl)-o-benzyl-serine and n-(terc butoxy-carbonyl)-o-benzyl-treonine
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Process for producing optically active n-(terc butoxy-carbonyl)-o-benzyl-serine and n-(terc butoxy-carbonyl)-o-benzyl-treonine
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Publication number
HUT53593A
HUT53593AHU238089AHU238089AHUT53593AHU T53593 AHUT53593 AHU T53593AHU 238089 AHU238089 AHU 238089AHU 238089 AHU238089 AHU 238089AHU T53593 AHUT53593 AHU T53593A
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Application filed by Reanal FinomvegyszergyarfiledCriticalReanal Finomvegyszergyar
Priority to HU238089ApriorityCriticalpatent/HU203524B/en
Publication of HUT53593ApublicationCriticalpatent/HUT53593A/en
Publication of HU203524BpublicationCriticalpatent/HU203524B/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Optically active N-(tert-butoxy-carbonyl) -o-benzyl-serine and N-(tert-butoxy-carboxyl) -o-benzyl-threonine and their salts with bases are prepd. by acylating optically active serine or with tert-butenyl-carbonate in the presence of an alkali-hydroxide to obtain optically active N-(tert-butoxy- carmrbonyl-)-serine, or -threonine. These are benzylated in the presence of an alkali-hydroxide, in the reaction mix with benzyl-chloride, at 5-15 deg.C. Both reaction steps are performed in anhydr. di:methyl-sulphoxide. Products are isolated as free acids or as their alkali salts
HU238089A1989-05-121989-05-12Process for producing optically active n-(terc-butoxy-carbonyl)-o-benzyl-serine and n-(terc-butoxy-carbonyl)-o-benzyl)-treonine
HU203524B
(en)