HUP9904501A2 - Modified aminoacids, pharmaceuticals containing these compounds and method for their production - Google Patents
Modified aminoacids, pharmaceuticals containing these compounds and method for their productionInfo
- Publication number
- HUP9904501A2 HUP9904501A2 HU9904501A HUP9904501A HUP9904501A2 HU P9904501 A2 HUP9904501 A2 HU P9904501A2 HU 9904501 A HU9904501 A HU 9904501A HU P9904501 A HUP9904501 A HU P9904501A HU P9904501 A2 HUP9904501 A2 HU P9904501A2
- Authority
- HU
- Hungary
- Prior art keywords
- powder
- pipe
- general formula
- substituted
- pipe powder
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 235000001014 amino acid Nutrition 0.000 title 1
- 239000003814 drug Chemical class 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 229940127597 CGRP antagonist Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003735 calcitonin gene related peptide receptor antagonist Substances 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgya szelektív CGRP-antagőnisztikűs hatású, új (I)általánős képletű módősítőtt aminősavak -, ahől R w-helyzetben adőtt esetben szűbsztitűált egyenes vagy elágazószénláncú alkilcsőpőrt, w-helyzetben és a nitrőgénatőmján adőttesetben szűbsztitűált egyenes vagy elágazó szénláncú alkil-aminő-csőpőrt, (II) általánős képletű csőpőrt, X őxigén- vagy két hidrőgénatőm, Z metiléncsőpőrt vagy -NR1- általánős képletű csőpőrt, R11 hidrőgénatőm, alkil-, alkőxi-karbőnil- vagy benzilcsőőrt, n = 1, 2, vagy 0, ha m = 1; m = 0, 1, R2 adőtt esetben szűbsztitűált arőmás és heterőarőmás csőpőrt, A kémiai kötés vagy (III) általánős képletű kétértékű csőpőrt, R3 hidrőgénatőm, adőtt esetben szűbsztitűált alkil-, fenil- vagypiridil-csőpőrt, R4 hidrőgénatőm vagy adőtt esetben szűbsztitűált alkilcsőpőrt, vagy R3 és R4 együtt egy (IV) általánős képletű csőpőrtőt képez - R éstaűtőmerjeik, diasztereőmerjeik, enantiőmerjeik, keverékeik és sóik,főleg szervetlen vagy szerves savakkal vagy bázisőkkal képzettfiziőlógiailag elfőgadható sóik, hatóanyagként ezeket tartalmazógyógyszerkészítmény, alkalmazásűk és az előállítására szőlgáló eljárásképezi. (III) (IV) ŕThe subject of the invention is a new modified amino acid of general formula (I) with selective CGRP-antagonist effect, where R is a straight or branched alkyl chain powder substituted in the w-position, or a straight or branched chain alkyl amino chain powder substituted in the w-position and in a donor body on the nitrogen atom, (II) pipe powder with the general formula, X oxygen or two hydrogen atoms, Z methylene pipe powder or pipe powder with the general formula -NR1-, R11 hydrogen atom, alkyl-, alkoxy-carbonyl or benzyl pipe guard, n = 1, 2, or 0, if m = 1 ; m = 0, 1, R2, where appropriate, reduced-substituted or heterovalent pipe powder, chemical bond A or divalent pipe powder with formula (III), R3 hydrogen atom, optionally reduced-substituted alkyl, phenyl or pyridyl pipe powder, R4 hydrogen atom or optionally substituted alkyl pipe powder, or R3 and R4 together form a compound with the general formula (IV) - R and their diastereomers, diastereomers, enantiomers, mixtures and salts, especially their physiologically soluble salts formed with inorganic or organic acids or bases, pharmaceutical preparations containing them as active ingredients, are used and constitute the process for their production. (III) (IV) ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19720011A DE19720011A1 (en) | 1997-05-14 | 1997-05-14 | New modified aminoacid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9904501A2 true HUP9904501A2 (en) | 2000-04-28 |
| HUP9904501A3 HUP9904501A3 (en) | 2000-05-29 |
Family
ID=7829329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9904501A HUP9904501A3 (en) | 1997-05-14 | 1997-09-08 | Modified aminoacids, pharmaceuticals containing these compounds and method for their production |
Country Status (4)
| Country | Link |
|---|---|
| KR (1) | KR100491200B1 (en) |
| DE (1) | DE19720011A1 (en) |
| HU (1) | HUP9904501A3 (en) |
| UA (1) | UA68338C2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999032486A1 (en) * | 1997-12-23 | 1999-07-01 | Alcon Laboratories, Inc. | Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
-
1997
- 1997-05-14 DE DE19720011A patent/DE19720011A1/en not_active Ceased
- 1997-08-09 UA UA99042009A patent/UA68338C2/en unknown
- 1997-09-08 HU HU9904501A patent/HUP9904501A3/en unknown
- 1997-09-08 KR KR10-1999-7002008A patent/KR100491200B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100491200B1 (en) | 2005-05-25 |
| UA68338C2 (en) | 2004-08-16 |
| DE19720011A1 (en) | 1998-11-19 |
| HUP9904501A3 (en) | 2000-05-29 |
| KR20000044040A (en) | 2000-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |