HUP9904235A2 - Új szerkezetek és vektorok gének célzott és indukálható kifejezésére - Google Patents
Új szerkezetek és vektorok gének célzott és indukálható kifejezéséreInfo
- Publication number
- HUP9904235A2 HUP9904235A2 HU9904235A HUP9904235A HUP9904235A2 HU P9904235 A2 HUP9904235 A2 HU P9904235A2 HU 9904235 A HU9904235 A HU 9904235A HU P9904235 A HUP9904235 A HU P9904235A HU P9904235 A2 HUP9904235 A2 HU P9904235A2
- Authority
- HU
- Hungary
- Prior art keywords
- genes
- vectors
- targeted
- inducible expression
- novel constructs
- Prior art date
Links
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000013598 vector Substances 0.000 title abstract 2
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgyát őlyan új szerkezetek és új vektőrők képezik,melyek gének indűkálható és májspecifikűs kifejezését teszik lehetővé.A találmány tárgyát részletesebben új hibrid prőmótereket, valamintazők alkalmazása képezi gének in vitrő, ex vivő vagy in vivőkifejezésére májsejtekben. A találmány vőnatkőzik még a prőmótert ésegy PPAR aktivátőrt tartalmazó készítményre is. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9613691A FR2755699B1 (fr) | 1996-11-08 | 1996-11-08 | Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9904235A2 true HUP9904235A2 (hu) | 2000-04-28 |
HUP9904235A3 HUP9904235A3 (en) | 2003-03-28 |
Family
ID=9497481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9904235A HUP9904235A3 (en) | 1996-11-08 | 1997-11-06 | Novel constructs and vectors for the targeted and inducible expression of genes |
Country Status (15)
Country | Link |
---|---|
US (1) | US20020144302A1 (hu) |
EP (1) | EP0946740A1 (hu) |
JP (1) | JP2001503279A (hu) |
KR (1) | KR20000053163A (hu) |
AU (1) | AU5057898A (hu) |
BR (1) | BR9713981A (hu) |
CA (1) | CA2269864A1 (hu) |
CZ (1) | CZ163399A3 (hu) |
FR (1) | FR2755699B1 (hu) |
HU (1) | HUP9904235A3 (hu) |
IL (1) | IL129593A0 (hu) |
NO (1) | NO992153L (hu) |
SK (1) | SK61499A3 (hu) |
WO (1) | WO1998021349A1 (hu) |
ZA (1) | ZA9710114B (hu) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7098025B1 (en) | 1997-07-25 | 2006-08-29 | Ligand Pharmaceuticals Incorporated | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor |
FR2795425B1 (fr) * | 1999-06-22 | 2003-12-05 | Aventis Pharma Sa | Systeme de regulation pharmacologique de l'expression utilisant les recepteurs nucleaires par et leurs ligands |
BR0011897A (pt) * | 1999-06-22 | 2002-03-26 | Aventis Pharma Sa | Composição, vetor, utilização de uma composição, processos para expressão regulada de um ácido nucleico em uma célula, para regulação da expressão de um ácido nucleico e para identificação de ligandos dos ppar, célula, ppar modificado, e, ácido nucleico |
FR2806418B1 (fr) * | 2000-03-14 | 2004-07-16 | Aventis Pharma Sa | Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations |
DK1263978T3 (da) * | 2000-03-14 | 2006-04-18 | Univ Paris Curie | Hybridpromotorer som kan induceres af inflammation, vektorer indeholdende disse og anvendelse deraf |
EP1288303A1 (en) * | 2001-08-23 | 2003-03-05 | Aventis Pharma S.A. | Inducible expression systems employing PPAR transcriptional activators |
AU2002333682A1 (en) * | 2001-08-02 | 2003-02-17 | Gencell S.A. | Inducible expression systems employing ppar transcriptional activators |
US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
CN112041437A (zh) | 2018-02-19 | 2020-12-04 | 同源药物公司 | 用于恢复f8基因功能的腺相关病毒组合物和其使用方法 |
TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2070058A1 (en) * | 1991-05-31 | 1992-12-01 | Robert A. Gadski | Vectors and methods for assaying the regulation of apolipoprotein ai synthesis |
FR2704556B1 (fr) * | 1993-04-30 | 1995-07-13 | Rhone Poulenc Rorer Sa | Virus recombinants et leur utilisation en thérapie génique. |
FR2718329B1 (fr) * | 1994-03-21 | 2002-09-20 | Rhone Poulenc Rorer Sa | Lapin transgénique sensibilisé aux dyslipoprotéinémies. |
FR2726285B1 (fr) * | 1994-10-28 | 1996-11-29 | Centre Nat Rech Scient | Adenovirus depourvus de particules contaminantes viables, preparation et utilisation |
-
1996
- 1996-11-08 FR FR9613691A patent/FR2755699B1/fr not_active Expired - Fee Related
-
1997
- 1997-11-06 EP EP97913264A patent/EP0946740A1/fr not_active Withdrawn
- 1997-11-06 WO PCT/FR1997/001992 patent/WO1998021349A1/fr not_active Application Discontinuation
- 1997-11-06 CZ CZ991633A patent/CZ163399A3/cs unknown
- 1997-11-06 BR BR9713981-5A patent/BR9713981A/pt not_active IP Right Cessation
- 1997-11-06 KR KR1019990704102A patent/KR20000053163A/ko not_active Application Discontinuation
- 1997-11-06 HU HU9904235A patent/HUP9904235A3/hu unknown
- 1997-11-06 CA CA002269864A patent/CA2269864A1/fr not_active Abandoned
- 1997-11-06 US US09/297,910 patent/US20020144302A1/en not_active Abandoned
- 1997-11-06 JP JP52223498A patent/JP2001503279A/ja active Pending
- 1997-11-06 SK SK614-99A patent/SK61499A3/sk unknown
- 1997-11-06 IL IL12959397A patent/IL129593A0/xx unknown
- 1997-11-06 AU AU50578/98A patent/AU5057898A/en not_active Abandoned
- 1997-11-10 ZA ZA9710114A patent/ZA9710114B/xx unknown
-
1999
- 1999-05-04 NO NO992153A patent/NO992153L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BR9713981A (pt) | 2000-05-02 |
NO992153D0 (no) | 1999-05-04 |
AU5057898A (en) | 1998-06-03 |
SK61499A3 (en) | 2000-02-14 |
IL129593A0 (en) | 2000-02-29 |
JP2001503279A (ja) | 2001-03-13 |
EP0946740A1 (fr) | 1999-10-06 |
HUP9904235A3 (en) | 2003-03-28 |
CZ163399A3 (cs) | 1999-08-11 |
FR2755699B1 (fr) | 1998-12-18 |
WO1998021349A1 (fr) | 1998-05-22 |
ZA9710114B (en) | 1998-06-08 |
FR2755699A1 (fr) | 1998-05-15 |
CA2269864A1 (fr) | 1998-05-22 |
KR20000053163A (ko) | 2000-08-25 |
US20020144302A1 (en) | 2002-10-03 |
NO992153L (no) | 1999-05-04 |
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