HUP9903870A2 - Piperazine derivatives and process for the preparation thereof - Google Patents
Piperazine derivatives and process for the preparation thereofInfo
- Publication number
- HUP9903870A2 HUP9903870A2 HU9903870A HUP9903870A HUP9903870A2 HU P9903870 A2 HUP9903870 A2 HU P9903870A2 HU 9903870 A HU9903870 A HU 9903870A HU P9903870 A HUP9903870 A HU P9903870A HU P9903870 A2 HUP9903870 A2 HU P9903870A2
- Authority
- HU
- Hungary
- Prior art keywords
- optionally substituted
- alkyl
- thioalkoxy
- alkoxy
- piperazine derivatives
- Prior art date
Links
- 150000004885 piperazines Chemical class 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005309 thioalkoxy group Chemical group 0.000 abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- -1 arylhydroxy Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000007970 thio esters Chemical class 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 abstract 1
Abstract
Piperazine derivatives of formula (I) and their acid addition salts are new. R1, R2 = 1-8C alkyl, 3-6C cycloalkyl, 2-8C unsaturated alkyl, aryl, 1-4C alkoxy, arylhydroxy, amino, carboxy, 1-4C lower thioalkoxy (all optionally substituted), H, ketone, 1-4C lower ester or thioester, thiol or epoxy; or R1+R2 = 3-4C optionally unsaturated chain; R3-R7 = 3-6C cycloalkyl, aryl, lower arylalkoxy or lower alkylamino (all optionally substituted), carbamate (optionally substituted by lower alkyl), H, halo, OH, NO2, 1-4C lower ester, 1-4C lower alkyl, 1-4C lower thioalkyl, 1-4C lower alkoxy or 1-4C lower thioalkoxy; or two adjacent R3-R7 form 1,2-phenylene or 2,3-naphthylene; X = O, S or optionally substituted imino; Y = O or NR3; Z = OH, 1-4C lower alkoxy, 1-4C lower thioalkoxy, 1-4C lower alkylamino, aryloxy (optionally substituted) or cycloamino (containing 1-5 N and being optionally substituted); and A = N or CH.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019970023193A KR100197111B1 (en) | 1996-09-18 | 1997-06-04 | Novel piperazine derivatives and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9903870A2 true HUP9903870A2 (en) | 2000-05-28 |
| HUP9903870A3 HUP9903870A3 (en) | 2002-01-28 |
Family
ID=19508656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9903870A HUP9903870A3 (en) | 1997-06-04 | 1997-06-28 | Piperazine derivatives and process for the preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP9903870A3 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7812025B2 (en) * | 2005-08-12 | 2010-10-12 | Takeda Pharmaceutical Company Limited | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder |
| US7851473B2 (en) * | 2004-11-18 | 2010-12-14 | Takeda Pharmaceutical Company Limited | Amide compound |
-
1997
- 1997-06-28 HU HU9903870A patent/HUP9903870A3/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7851473B2 (en) * | 2004-11-18 | 2010-12-14 | Takeda Pharmaceutical Company Limited | Amide compound |
| US7812025B2 (en) * | 2005-08-12 | 2010-10-12 | Takeda Pharmaceutical Company Limited | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder |
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9903870A3 (en) | 2002-01-28 |
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