HUP9902429A2 - TNF-receptor-asszociált faktor (TRAF) modulátorok előállítása és alkalmazása - Google Patents
TNF-receptor-asszociált faktor (TRAF) modulátorok előállítása és alkalmazásaInfo
- Publication number
- HUP9902429A2 HUP9902429A2 HU9902429A HUP9902429A HUP9902429A2 HU P9902429 A2 HUP9902429 A2 HU P9902429A2 HU 9902429 A HU9902429 A HU 9902429A HU P9902429 A HUP9902429 A HU P9902429A HU P9902429 A2 HUP9902429 A2 HU P9902429A2
- Authority
- HU
- Hungary
- Prior art keywords
- traf2
- proteins
- binding
- dna sequences
- traf
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 102000008889 TNF receptor-associated factor TRAF Human genes 0.000 title 1
- 108050000808 TNF receptor-associated factor TRAF Proteins 0.000 title 1
- 102000004393 TNF receptor-associated factor 2 Human genes 0.000 abstract 6
- 108090000925 TNF receptor-associated factor 2 Proteins 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 3
- 230000001404 mediated effect Effects 0.000 abstract 3
- 230000001575 pathological effect Effects 0.000 abstract 2
- 108010057466 NF-kappa B Proteins 0.000 abstract 1
- 102000003945 NF-kappa B Human genes 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
A találmány tárgyát TRAF2-faktőrhőz kötődni képes prőteineket és azőkTRAF2-prőteinhez kötődni képes izőfőrmjait, analógjait vagyszármazékait kódőló DNS-szekvenciák képezik, valamint a találmányszerinti DNS-szekvenciák által kódőlt prőteinek, és azők TRAF2-prőteinhez kötődni képes izőfőrmjai, analógjai, fragmensei ésszármazékai, valamint az ellenük termeltetett ellenanyagők. Atalálmány tárgyát képezik a TRAF2-prőteinek általmódősítőtt/közvetített cellűláris hatásők módősítására alkalmasgyógyászati készítmények is, tővábbá a találmány szerinti prőteinek,DNS-szekvenciák, ellenanyagők és gyógyászati készítmények alkalmazása,NF-kB-indűkcióval és más, TRAF2-faktőr közvetítette aktivitássalkapcsőlatős kórős állapőt kezelésére. A találmány szerinti megőldásalkalmas TRAF2-faktőr közvetítette aktivitással kapcsőlatős kórősállapőtők kezelésére, megelőzésére. ŕ
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11780096A IL117800A0 (en) | 1996-04-02 | 1996-04-02 | Modulators of TNF receptor associated factor (TRAF) their preparation and use |
IL11913396A IL119133A0 (en) | 1996-08-26 | 1996-08-26 | Modulators of TNF receptor associated factor (TRAF) their preparation and use |
PCT/IL1997/000117 WO1997037016A1 (en) | 1996-04-02 | 1997-04-01 | Modulators of tnf receptor associated factor (traf), their preparation and use |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9902429A2 true HUP9902429A2 (hu) | 1999-10-28 |
HUP9902429A3 HUP9902429A3 (en) | 2001-11-28 |
HU226328B1 HU226328B1 (en) | 2008-09-29 |
Family
ID=26323248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9902429A HU226328B1 (en) | 1996-04-02 | 1997-04-01 | Modulators of tnf receptor associated factor (traf), their preparation and use |
Country Status (23)
Country | Link |
---|---|
US (2) | US7485456B1 (hu) |
EP (1) | EP0894130B1 (hu) |
JP (1) | JP4180114B2 (hu) |
CN (1) | CN1197966C (hu) |
AT (1) | ATE380866T1 (hu) |
AU (1) | AU732793B2 (hu) |
BG (1) | BG64755B1 (hu) |
BR (1) | BR9708518A (hu) |
CA (1) | CA2250085C (hu) |
CZ (3) | CZ299682B6 (hu) |
DE (1) | DE69738370T2 (hu) |
DK (1) | DK0894130T3 (hu) |
EA (1) | EA004309B1 (hu) |
EE (1) | EE04783B1 (hu) |
ES (1) | ES2294796T3 (hu) |
HK (1) | HK1018910A1 (hu) |
HU (1) | HU226328B1 (hu) |
NO (1) | NO327054B1 (hu) |
NZ (1) | NZ331902A (hu) |
PT (1) | PT894130E (hu) |
SK (3) | SK287889B6 (hu) |
UA (1) | UA71889C2 (hu) |
WO (1) | WO1997037016A1 (hu) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA71889C2 (uk) * | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
US5843721A (en) * | 1997-07-03 | 1998-12-01 | Tularik Inc. | Nucleic acids encoding human NIK protein |
EP1028974A1 (en) * | 1997-11-07 | 2000-08-23 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
AU2877899A (en) * | 1998-02-27 | 1999-09-15 | Regents Of The University Of California, The | A novel inhibitor of the inflammatory response induced by tnfalpha and il-1 |
EP1075519B1 (en) * | 1998-05-06 | 2005-11-09 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Inhibitors of nf-kb activation |
MXPA01001747A (es) * | 1998-08-18 | 2003-06-06 | Basf Ag | Tpl-2/cot cinasa y metodos de uso. |
IL131719A0 (en) * | 1999-09-02 | 2001-03-19 | Yeda Res & Dev | Iren protein its preparation and use |
GB9930616D0 (en) * | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
US20040109854A1 (en) * | 2001-02-21 | 2004-06-10 | Zang-Hee Lee | Novel traf6 inhibiting protein |
DE60213596T2 (de) | 2001-06-22 | 2007-09-13 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Abin zum schutz gegen hepatitis |
AU2003222415B2 (en) * | 2002-04-18 | 2009-02-05 | Yeda Research And Development Co. Ltd. | Derivatives of the IL-2 receptor gamma chain, their production and use |
IL158287A0 (en) * | 2003-10-07 | 2004-05-12 | Yeda Res & Dev | Antibodies to nik, their preparation and use |
AU2004278175B2 (en) * | 2003-10-07 | 2010-11-04 | Yeda Research And Development Co. Ltd. | Antibodies to NIK, their preparation and use |
US8034340B2 (en) | 2003-11-30 | 2011-10-11 | Yeda Research And Development Ltd. | Method for treating an immune disorder by decreasing NIK-SIVA complex formation |
IL173104A0 (en) * | 2006-01-12 | 2006-06-11 | Yeda Res & Dev | Siva and ubiquintination |
KR20110036638A (ko) | 2008-07-25 | 2011-04-07 | 리차드 더블유. 와그너 | 단백질 스크리닝 방법 |
GB201012420D0 (en) | 2010-07-23 | 2010-09-08 | Univ Erasmus Medical Ct | Foetal heamoglobin inhibitor |
EP2608801B1 (en) | 2010-08-25 | 2019-08-21 | aTyr Pharma, Inc. | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES |
CN105177032B (zh) * | 2010-09-01 | 2019-05-10 | 山东新时代药业有限公司 | 新型人肿瘤坏死因子受体-Fc融合基因及其产物蛋白 |
AR085908A1 (es) | 2011-03-16 | 2013-11-06 | Hoffmann La Roche | DERIVADOS DE 3-BUTIN-2-OL Y DE CARBONITRILO CON ACTIVIDAD INHIBIDORA DE LA QUINASA INDUCTORA DE NF-kB (NIK) |
AU2012275133B2 (en) | 2011-06-30 | 2017-08-17 | Genzyme Corporation | Inhibitors of T-cell activation |
WO2013010749A1 (en) | 2011-07-19 | 2013-01-24 | Philogen S.P.A | Sequential anti - ctla4 and targeted il-2 therapy |
UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
CA2974651A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
CN105986001B (zh) * | 2015-02-12 | 2019-12-03 | 上海交通大学 | 一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法 |
MA55529A (fr) | 2019-04-03 | 2022-02-09 | Genzyme Corp | Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite |
WO2024062074A1 (en) | 2022-09-21 | 2024-03-28 | Sanofi Biotechnology | Humanized anti-il-1r3 antibody and methods of use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5641876A (en) * | 1990-01-05 | 1997-06-24 | Cornell Research Foundation, Inc. | Rice actin gene and promoter |
WO1997004793A1 (en) * | 1995-08-02 | 1997-02-13 | Ingram Teresa J | Composition for administration to patients with chronic fatigue syndrome and acquired immune deficiency syndrome |
AU6692996A (en) | 1995-08-08 | 1997-03-05 | Tularik Inc. | Inhibitors of apoptosis |
US5804412A (en) * | 1996-04-01 | 1998-09-08 | The Regents Of The University Of California | Nucleic acids encoding sorting nexins and methods of using same |
UA71889C2 (uk) * | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
AU2668297A (en) | 1996-05-08 | 1997-11-26 | Henkel Corporation | Alkyl polyglycoside ether carboxylates |
US5843721A (en) * | 1997-07-03 | 1998-12-01 | Tularik Inc. | Nucleic acids encoding human NIK protein |
-
1997
- 1997-01-04 UA UA98105743A patent/UA71889C2/uk unknown
- 1997-04-01 EA EA199800885A patent/EA004309B1/ru not_active IP Right Cessation
- 1997-04-01 CZ CZ0318398A patent/CZ299682B6/cs not_active IP Right Cessation
- 1997-04-01 CN CNB971951934A patent/CN1197966C/zh not_active Expired - Lifetime
- 1997-04-01 CZ CZ20060017A patent/CZ298866B6/cs not_active IP Right Cessation
- 1997-04-01 EP EP97914534A patent/EP0894130B1/en not_active Expired - Lifetime
- 1997-04-01 SK SK50016-2007A patent/SK287889B6/sk not_active IP Right Cessation
- 1997-04-01 CA CA002250085A patent/CA2250085C/en not_active Expired - Lifetime
- 1997-04-01 CZ CZ20060018A patent/CZ299094B6/cs not_active IP Right Cessation
- 1997-04-01 AT AT97914534T patent/ATE380866T1/de active
- 1997-04-01 EE EE9800322A patent/EE04783B1/xx unknown
- 1997-04-01 ES ES97914534T patent/ES2294796T3/es not_active Expired - Lifetime
- 1997-04-01 WO PCT/IL1997/000117 patent/WO1997037016A1/en active IP Right Grant
- 1997-04-01 PT PT97914534T patent/PT894130E/pt unknown
- 1997-04-01 JP JP53509997A patent/JP4180114B2/ja not_active Expired - Lifetime
- 1997-04-01 BR BR9708518A patent/BR9708518A/pt not_active Application Discontinuation
- 1997-04-01 SK SK1361-98A patent/SK287085B6/sk not_active IP Right Cessation
- 1997-04-01 US US09/155,676 patent/US7485456B1/en not_active Expired - Fee Related
- 1997-04-01 DK DK97914534T patent/DK0894130T3/da active
- 1997-04-01 AU AU21755/97A patent/AU732793B2/en not_active Expired
- 1997-04-01 NZ NZ331902A patent/NZ331902A/en not_active IP Right Cessation
- 1997-04-01 SK SK50017-2007A patent/SK287890B6/sk not_active IP Right Cessation
- 1997-04-01 DE DE69738370T patent/DE69738370T2/de not_active Expired - Lifetime
- 1997-04-01 HU HU9902429A patent/HU226328B1/hu unknown
-
1998
- 1998-09-29 NO NO19984551A patent/NO327054B1/no not_active IP Right Cessation
- 1998-10-07 BG BG102817A patent/BG64755B1/bg unknown
-
1999
- 1999-09-15 HK HK99104000A patent/HK1018910A1/xx not_active IP Right Cessation
-
2009
- 2009-02-03 US US12/365,136 patent/US8236507B2/en not_active Expired - Fee Related
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