HUP9902417A2 - Alfa-ketoészterek, és alfa-ketoamidok acilezett enol-származékai - Google Patents

Alfa-ketoészterek, és alfa-ketoamidok acilezett enol-származékai

Info

Publication number
HUP9902417A2
HUP9902417A2 HU9902417A HUP9902417A HUP9902417A2 HU P9902417 A2 HUP9902417 A2 HU P9902417A2 HU 9902417 A HU9902417 A HU 9902417A HU P9902417 A HUP9902417 A HU P9902417A HU P9902417 A2 HUP9902417 A2 HU P9902417A2
Authority
HU
Hungary
Prior art keywords
alfa
ketoamides
ketoesters
partly
elastase
Prior art date
Application number
HU9902417A
Other languages
English (en)
Inventor
Joseph P. Burkhart
Shujaath Mehdi
Norton P. Peet
Original Assignee
Hoechst Marion Roussel, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel, Inc. filed Critical Hoechst Marion Roussel, Inc.
Publication of HUP9902417A2 publication Critical patent/HUP9902417A2/hu
Publication of HUP9902417A3 publication Critical patent/HUP9902417A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya (I) vagy (IA) általánős képletű alfa-ketőészterekés alfaketőamidők acilezett enőlszármazékai. A találmány szerintivegyületek részint elasztáz inhibitőr hatásúak, részint elasztázinhibitőr hatásúk, részint elasztáz inhibitőrők prődrűgjai, amelyekgyűlladás elleni hatásűk következtében számős kórkép kezelésébenalkalmazhatók. ŕ
HU9902417A 1995-12-01 1996-11-04 Acylated enol derivatives of alfa-ketoesters and alfa-ketoamides HUP9902417A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56619695A 1995-12-01 1995-12-01

Publications (2)

Publication Number Publication Date
HUP9902417A2 true HUP9902417A2 (hu) 1999-11-29
HUP9902417A3 HUP9902417A3 (en) 2000-11-28

Family

ID=24261904

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902417A HUP9902417A3 (en) 1995-12-01 1996-11-04 Acylated enol derivatives of alfa-ketoesters and alfa-ketoamides

Country Status (20)

Country Link
EP (1) EP0863915B1 (hu)
JP (1) JP2000502073A (hu)
KR (1) KR19990071822A (hu)
CN (1) CN1127512C (hu)
AR (1) AR005240A1 (hu)
AT (1) ATE189457T1 (hu)
AU (1) AU705819B2 (hu)
CA (1) CA2239159C (hu)
DE (1) DE69606552T2 (hu)
ES (1) ES2144788T3 (hu)
GR (1) GR3033205T3 (hu)
HU (1) HUP9902417A3 (hu)
IL (1) IL124499A (hu)
MX (1) MX9804265A (hu)
NO (1) NO982467L (hu)
NZ (1) NZ322731A (hu)
PT (1) PT863915E (hu)
TW (1) TW419482B (hu)
WO (1) WO1997020856A1 (hu)
ZA (1) ZA969889B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3359697A (en) * 1996-07-08 1998-02-02 Yamanouchi Pharmaceutical Co., Ltd. Bone resorption inhibitors
US6645939B1 (en) 1997-11-24 2003-11-11 Merck & Co., Inc. Substituted β-alanine derivatives as cell adhesion inhibitors
JP2001524465A (ja) * 1997-11-24 2001-12-04 メルク エンド カムパニー インコーポレーテッド 細胞接着阻害剤としての置換β−アラニン誘導体
WO2006113942A2 (en) * 2005-04-20 2006-10-26 Schering Corporation Method of inhibiting cathepsin activity
KR101012313B1 (ko) * 2008-06-10 2011-02-09 서울대학교산학협력단 염증질환 치료제

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378457A (en) * 1981-12-24 1995-01-03 Virogenetics Corporation Interferon sensitive recombinant poxvirus vaccine
WO1992012140A1 (en) * 1990-12-28 1992-07-23 Georgia Tech Research Corporation Peptides ketoamides, ketoacids, and ketoesters

Also Published As

Publication number Publication date
JP2000502073A (ja) 2000-02-22
NO982467L (no) 1998-08-03
WO1997020856A1 (en) 1997-06-12
IL124499A0 (en) 1998-12-06
GR3033205T3 (en) 2000-08-31
EP0863915B1 (en) 2000-02-02
KR19990071822A (ko) 1999-09-27
HUP9902417A3 (en) 2000-11-28
MX9804265A (es) 1998-09-30
NZ322731A (en) 1999-10-28
AU7669796A (en) 1997-06-27
AR005240A1 (es) 1999-04-28
CA2239159C (en) 2002-09-10
DE69606552D1 (de) 2000-03-09
ATE189457T1 (de) 2000-02-15
DE69606552T2 (de) 2000-09-14
ZA969889B (en) 1997-06-17
NO982467D0 (no) 1998-05-29
EP0863915A1 (en) 1998-09-16
AU705819B2 (en) 1999-06-03
TW419482B (en) 2001-01-21
CN1203602A (zh) 1998-12-30
CA2239159A1 (en) 1997-06-12
ES2144788T3 (es) 2000-06-16
PT863915E (pt) 2000-05-31
CN1127512C (zh) 2003-11-12
IL124499A (en) 2003-05-29

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