HUP9900227A2 - New pharmacological use of aii-receptor antagonists - Google Patents
New pharmacological use of aii-receptor antagonistsInfo
- Publication number
- HUP9900227A2 HUP9900227A2 HU9900227A HUP9900227A HUP9900227A2 HU P9900227 A2 HUP9900227 A2 HU P9900227A2 HU 9900227 A HU9900227 A HU 9900227A HU P9900227 A HUP9900227 A HU P9900227A HU P9900227 A2 HUP9900227 A2 HU P9900227A2
- Authority
- HU
- Hungary
- Prior art keywords
- receptor antagonists
- aii
- mof
- general formula
- treatment
- Prior art date
Links
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 abstract 2
- 208000034486 Multi-organ failure Diseases 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000002053 C09CA06 - Candesartan Substances 0.000 abstract 1
- 206010053159 Organ failure Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000400 angiotensin II type 1 receptor blocker Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229960000932 candesartan Drugs 0.000 abstract 1
- 229960004349 candesartan cilexetil Drugs 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgyát (I) általánős képletű angiőtenzin II 1 típűsú-receptőr antagőnisták többszörös szervrendszeri elégtelenség (műltiplesystem őrgan failűre; MOF) megelőzésére és/vagy kezelésére, és a MOFkezelésében hatásős gyógyszerkészítmények előállítására valófelhasználása képezi. Az (I) általánős képletű ismert antagőnistákközül különösen előnyös a lősartan[A = (I.1)] és a candesartanciletexil (TCV-116)[A = (I.5)] generikűs nevű hatóanyag. Azantagőnistákat semleges vagy só főrmában, racem keverékként vagytiszta enantiőmerként használják előnyösen injekciós gyógyszerfőrmákelőállítására, de őrális és rektális adagőlású készítmények iselőállíthatók. ŕThe subject of the invention is the use of angiotensin II type 1 receptor antagonists of general formula (I) for the prevention and/or treatment of multiple organ system failure (multiple system organ failure; MOF) and for the production of pharmaceutical preparations effective in the treatment of MOF. Among the known antagonists with the general formula (I), the active substances with the generic names lõsartan [A = (I.1)] and candesartan ciletexil (TCV-116) [A = (I.5)] are particularly preferred. Azanthine crystals are preferably used in neutral or salt form, as a racemic mixture or as a pure enantiomer for the production of injectable drug forms, but preparations for oral and rectal administration can also be produced. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9501881A SE9501881D0 (en) | 1995-05-19 | 1995-05-19 | New pharmacological use of AII receptor antagonists |
PCT/SE1996/000602 WO1996036336A1 (en) | 1995-05-19 | 1996-05-08 | New pharmacological use of aii-receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9900227A2 true HUP9900227A2 (en) | 2000-03-28 |
HUP9900227A3 HUP9900227A3 (en) | 2002-11-28 |
Family
ID=20398385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9900227A HUP9900227A3 (en) | 1995-05-19 | 1996-05-08 | New pharmacological use of aii-receptor antagonists |
Country Status (23)
Country | Link |
---|---|
US (1) | US5900428A (en) |
EP (1) | EP0830131A1 (en) |
JP (1) | JPH11505243A (en) |
KR (1) | KR19990014905A (en) |
CN (1) | CN1093761C (en) |
AU (1) | AU706301B2 (en) |
BR (1) | BR9608407A (en) |
CA (1) | CA2219395A1 (en) |
CZ (1) | CZ290155B6 (en) |
EE (1) | EE03666B1 (en) |
HU (1) | HUP9900227A3 (en) |
IL (1) | IL118299A (en) |
IS (1) | IS4597A (en) |
MX (1) | MX9708557A (en) |
MY (1) | MY114428A (en) |
NO (1) | NO975221L (en) |
NZ (1) | NZ308260A (en) |
RU (1) | RU2194505C2 (en) |
SE (1) | SE9501881D0 (en) |
SK (1) | SK151397A3 (en) |
TW (1) | TW473389B (en) |
WO (1) | WO1996036336A1 (en) |
ZA (1) | ZA963569B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW580397B (en) * | 1997-05-27 | 2004-03-21 | Takeda Chemical Industries Ltd | Solid preparation |
US6514249B1 (en) | 1997-07-08 | 2003-02-04 | Atrionix, Inc. | Positioning system and method for orienting an ablation element within a pulmonary vein ostium |
SE9800550D0 (en) * | 1998-02-24 | 1998-02-24 | A & Science Invest Ab | A pharmaceutical preparation comprising an angiotensin II type 2 receptor agonist, and use thereof |
ES2274625T3 (en) | 1998-05-18 | 2007-05-16 | Takeda Pharmaceutical Company Limited | REMOVABLE TABLETS IN THE MOUTH THAT INCLUDE A BENCIMIDAZOL. |
AU4802099A (en) | 1998-07-28 | 2000-02-21 | Takeda Chemical Industries Ltd. | Rapidly disintegrable solid preparation |
EP1262180A4 (en) | 2000-02-18 | 2005-06-01 | Takeda Pharmaceutical | Tnf-alpha inhibitors |
JP4880591B2 (en) | 2004-06-04 | 2012-02-22 | テバ ファーマシューティカル インダストリーズ リミティド | Pharmaceutical composition comprising irbesartan |
KR20130074808A (en) | 2011-12-16 | 2013-07-05 | 한올바이오파마주식회사 | The pharmaceutical composition comprising losartan for treating or preventing statin-induced muscle toxicity |
CN104261284B (en) * | 2014-09-18 | 2016-02-03 | 中邮建技术有限公司 | A kind of antenna hanging apparatus of wireless base station |
WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
US5538991A (en) * | 1994-09-14 | 1996-07-23 | Merck & Co., Inc. | Endothelin antagonists bearing 5-membered heterocyclic amides |
-
1995
- 1995-05-19 SE SE9501881A patent/SE9501881D0/en unknown
-
1996
- 1996-05-06 ZA ZA963569A patent/ZA963569B/en unknown
- 1996-05-08 CZ CZ19973454A patent/CZ290155B6/en not_active IP Right Cessation
- 1996-05-08 HU HU9900227A patent/HUP9900227A3/en unknown
- 1996-05-08 AU AU57845/96A patent/AU706301B2/en not_active Ceased
- 1996-05-08 EE EE9700309A patent/EE03666B1/en not_active IP Right Cessation
- 1996-05-08 SK SK1513-97A patent/SK151397A3/en unknown
- 1996-05-08 MX MX9708557A patent/MX9708557A/en not_active IP Right Cessation
- 1996-05-08 CA CA002219395A patent/CA2219395A1/en not_active Abandoned
- 1996-05-08 US US08/696,971 patent/US5900428A/en not_active Expired - Fee Related
- 1996-05-08 WO PCT/SE1996/000602 patent/WO1996036336A1/en not_active Application Discontinuation
- 1996-05-08 EP EP96914504A patent/EP0830131A1/en not_active Withdrawn
- 1996-05-08 KR KR1019970708250A patent/KR19990014905A/en not_active Application Discontinuation
- 1996-05-08 CN CN96193988A patent/CN1093761C/en not_active Expired - Fee Related
- 1996-05-08 BR BR9608407A patent/BR9608407A/en not_active Application Discontinuation
- 1996-05-08 RU RU97120700/14A patent/RU2194505C2/en active
- 1996-05-08 JP JP8534742A patent/JPH11505243A/en active Pending
- 1996-05-08 NZ NZ308260A patent/NZ308260A/en unknown
- 1996-05-16 IL IL11829996A patent/IL118299A/en not_active IP Right Cessation
- 1996-05-18 MY MYPI96001899A patent/MY114428A/en unknown
- 1996-06-08 TW TW085106910A patent/TW473389B/en not_active IP Right Cessation
-
1997
- 1997-10-22 IS IS4597A patent/IS4597A/en unknown
- 1997-11-13 NO NO975221A patent/NO975221L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL118299A (en) | 2000-07-26 |
CN1093761C (en) | 2002-11-06 |
US5900428A (en) | 1999-05-04 |
TW473389B (en) | 2002-01-21 |
NZ308260A (en) | 2000-12-22 |
CZ345497A3 (en) | 1998-03-18 |
HUP9900227A3 (en) | 2002-11-28 |
CA2219395A1 (en) | 1996-11-21 |
RU2194505C2 (en) | 2002-12-20 |
CZ290155B6 (en) | 2002-06-12 |
NO975221D0 (en) | 1997-11-13 |
IS4597A (en) | 1997-10-22 |
JPH11505243A (en) | 1999-05-18 |
MY114428A (en) | 2002-10-31 |
EP0830131A1 (en) | 1998-03-25 |
EE03666B1 (en) | 2002-04-15 |
BR9608407A (en) | 1998-12-29 |
SE9501881D0 (en) | 1995-05-19 |
KR19990014905A (en) | 1999-02-25 |
AU5784596A (en) | 1996-11-29 |
ZA963569B (en) | 1996-11-19 |
MX9708557A (en) | 1997-12-31 |
SK151397A3 (en) | 1998-08-05 |
WO1996036336A1 (en) | 1996-11-21 |
AU706301B2 (en) | 1999-06-10 |
EE9700309A (en) | 1998-06-15 |
NO975221L (en) | 1997-11-13 |
IL118299A0 (en) | 1996-09-12 |
CN1184424A (en) | 1998-06-10 |
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