HUP9800813A2 - Laktám-tartalmú hidroxámsav-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Laktám-tartalmú hidroxámsav-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9800813A2 HUP9800813A2 HU9800813A HUP9800813A HUP9800813A2 HU P9800813 A2 HUP9800813 A2 HU P9800813A2 HU 9800813 A HU9800813 A HU 9800813A HU P9800813 A HUP9800813 A HU P9800813A HU P9800813 A2 HUP9800813 A2 HU P9800813A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- carbocyclic
- heterocyclic
- heteroalkyl
- hydrogen
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000003951 lactams Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 239000000843 powder Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002837 carbocyclic group Chemical group 0.000 abstract 3
- 125000005343 heterocyclic alkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- -1 carbocyclic-alkyl- Chemical group 0.000 abstract 2
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004474 heteroalkylene group Chemical group 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A találmány tárgyát a mátrix metallőprőteázők túlzőtt és/vagynemkívánatős aktivitásáhőz, különösen a kőllagenáz és/vagy astrőmelizin aktivitásáhőz kapcsőlódó betegségek kezelésére alkalmas(I) általánős képletű vegyületek - ahőlR1hidrőgén, alkil-, heterőalkil-, heterőciklűsős, karbőciklűsős,alkőxi-, karbőciklűsős-alkil-, karbőciklűsős-heterőalkil- vagyheterőciklűsős-heterőalkil-csőpőrt;R2hidrőgén, hidrőxi-, alkil-, alkenil-, alkinil-, heterőalkil-,heterőciklűsős, karbőciklűsős-alkil-, heterőciklűsős-alkil-csőpőrtvagy őlyan -OR csőpőrt, amelybenRalkil-, alkenil- vagy karbőciklűsős-alkil-csőpőrt; vagyR1 és R2 együtt 3-8 tagú ciklőalkil-gyűrűt képeznek;R3hidrőgén, alkil- vagy karbőciklűsős-alkil-csőpőrt;R4alkil-, heterőciklűsős-alkil-csőpőrt vagy -X-C(=Y)-Z-R5, -X-CH2-Z-R5vagy -SOZ-R6 általánős képletű csőpőrt; amelyekbenXkötés vagy alkilén-lánc;Y= -O-, -S- vagy -NH-;Z= -O-, -S- vagy -NH-; ésR5hidrőgén, alkil-, alkenil-, karbőciklűsős-alkil- vagy aril-csőpőrt; ésR6alkil-, karbőciklűsős-alkil-, heterőciklűsős-alkil- vagy aril-csőpőrt:ésQadőtt esetben egy vagy két alkilcsőpőrttal szűbsztitűált 2-4 tagúalkilén-, alkenilén-, heterőalkilén- vagy heterőalkenilén-lánc -gyógyászatilag elfőgadható sóik, biőhidrőlizálható alkőxi-amidjaik,acilőxi-amidjaik és imidjeik képezik.ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/407,839 US5672598A (en) | 1995-03-21 | 1995-03-21 | Lactam-containing hydroxamic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9800813A2 true HUP9800813A2 (hu) | 1998-07-28 |
HUP9800813A3 HUP9800813A3 (en) | 1998-09-28 |
Family
ID=23613737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9800813A HUP9800813A3 (en) | 1995-03-21 | 1996-03-19 | Lactam-containing hydroxamic acid derivatives, their preparation and pharmaceutical compositions containing them |
Country Status (17)
Country | Link |
---|---|
US (1) | US5672598A (hu) |
EP (1) | EP0815084B1 (hu) |
JP (1) | JPH11502523A (hu) |
KR (1) | KR19980703151A (hu) |
AR (1) | AR002718A1 (hu) |
AT (1) | ATE248150T1 (hu) |
AU (1) | AU711889B2 (hu) |
BR (1) | BR9607772A (hu) |
CA (1) | CA2216129C (hu) |
CZ (1) | CZ295197A3 (hu) |
DE (1) | DE69629670T2 (hu) |
HU (1) | HUP9800813A3 (hu) |
IL (1) | IL117527A (hu) |
NO (1) | NO974335L (hu) |
NZ (1) | NZ304689A (hu) |
WO (1) | WO1996029313A1 (hu) |
ZA (1) | ZA962253B (hu) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000516252A (ja) * | 1996-08-28 | 2000-12-05 | ザ プロクター アンド ギャンブル カンパニー | 1,4―複素環式メタロプロテアーゼ阻害剤 |
US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
CN1150205C (zh) * | 1996-09-19 | 2004-05-19 | 阿温蒂斯药物公司 | 用作基质金属蛋白酶抑制剂的3-巯基乙酰氨基-1.5-二取代的-2-氧代-氮杂环庚烷衍生物 |
PT934259E (pt) * | 1996-10-16 | 2003-01-31 | American Cyanamid Co | Acidos beta-sulfonamido hidroxamicos como inibidores de metaloproteinases de matriz e de tace |
US6174915B1 (en) | 1997-03-25 | 2001-01-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
US20030206874A1 (en) * | 1996-11-21 | 2003-11-06 | The Proctor & Gamble Company | Promoting whole body health |
US6211235B1 (en) | 1996-11-22 | 2001-04-03 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting β-amyloid peptide release and/or its synthesis |
US6191166B1 (en) | 1997-11-21 | 2001-02-20 | Elan Pharmaceuticals, Inc. | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis |
US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US20050058709A1 (en) * | 1997-06-04 | 2005-03-17 | Fisher Gary J. | Methods for inhibiting photoaging of human skin using orally-administered agent |
US6403632B1 (en) | 2000-03-01 | 2002-06-11 | Bristol Myers Squibb Pharma Co | Lactam metalloprotease inhibitors |
ZA988967B (en) * | 1997-10-03 | 2000-04-03 | Du Pont Pharm Co | Lactam metalloprotease inhibitors. |
US6335329B1 (en) * | 1997-12-19 | 2002-01-01 | Amgen Inc. | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use |
US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
US6569636B2 (en) * | 1998-05-29 | 2003-05-27 | Hawaii Biotechnology Group, Inc. | Assay for modulators of metallo-enzyme activity |
US6774125B2 (en) * | 1998-06-22 | 2004-08-10 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6569851B1 (en) | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
HRP990246A2 (en) * | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
NZ525513A (en) * | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
AU2003203805B8 (en) * | 1998-08-07 | 2007-02-15 | Bristol-Myers Squibb Pharma Company | Succinoylamino lactams as inhibitors of ABeta protein production |
AU1618000A (en) * | 1998-11-12 | 2000-05-29 | Du Pont Pharmaceuticals Company | Use of radioligands to screen inhibitors of amyloid-beta peptide production |
US6737038B1 (en) * | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
AU778005B2 (en) * | 1998-12-24 | 2004-11-11 | Bristol-Myers Squibb Pharma Company | Succinoylamino benzodiazepines as inhibitors of Abeta protein production |
EP1150976B1 (en) * | 1998-12-31 | 2003-02-26 | Aventis Pharmaceuticals Inc. | 3-(thio-substituted amido)-lactams useful as inhibitors of matrix metalloproteinase |
AU1836900A (en) * | 1998-12-31 | 2000-07-24 | Aventis Pharmaceuticals Inc. | N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase |
US6262080B1 (en) * | 1998-12-31 | 2001-07-17 | Avantis Pharmaceuticals Inc. | 3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase |
US6344450B1 (en) | 1999-02-09 | 2002-02-05 | Bristol-Myers Squibb Company | Lactam compounds and their use as inhibitors of serine proteases and method |
EP1175405A4 (en) * | 1999-02-09 | 2002-05-15 | Bristol Myers Squibb Co | LACTAM INHIBITORS OF FACTOR Xa AND ASSOCIATED METHOD |
WO2000047207A1 (en) | 1999-02-09 | 2000-08-17 | Bristol-Myers Squibb Company | LACTAM INHIBITORS OF FXa AND METHOD |
GB9929527D0 (en) * | 1999-12-14 | 2000-02-09 | Smithkline Beecham Plc | Novel compounds |
US6509330B2 (en) * | 2000-02-17 | 2003-01-21 | Bristol-Myers Squibb Company | Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors |
WO2001060826A2 (en) * | 2000-02-17 | 2001-08-23 | Bristol-Myers Squibb Pharma Company | SUCCINOYLAMINO CARBOCYCLES AND HETEROCYCLES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
MXPA02009755A (es) * | 2000-04-03 | 2003-03-27 | Bristol Myers Squibb Pharma Co | Lactamas ciclicas como inhibidores de la produccion de proteina a-beta. |
AU2001257006A1 (en) | 2000-04-11 | 2001-10-23 | Du Pont Pharmaceuticals Company | Substituted lactams as inhibitors of abeta protein production |
WO2001085716A1 (en) * | 2000-05-11 | 2001-11-15 | Kyowa Hakko Kogyo Co., Ltd | 2-piperidone compounds for the treatment of cancer |
US6878363B2 (en) | 2000-05-17 | 2005-04-12 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
IL147629A0 (en) | 2000-06-01 | 2002-08-14 | Bristol Myers Squibb Pharma Co | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
US8283135B2 (en) | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
AU2001271544A1 (en) * | 2000-06-30 | 2002-01-14 | The Procter And Gamble Company | Oral compositions comprising host-response modulating agent |
ATE401089T1 (de) * | 2000-06-30 | 2008-08-15 | Procter & Gamble | Orale zubereitungen, die antimikrobielle wirkstoffe enthalten zur prävention von systemischen erkrankungen |
US6511973B2 (en) | 2000-08-02 | 2003-01-28 | Bristol-Myers Squibb Co. | Lactam inhibitors of FXa and method |
WO2003033018A1 (en) * | 2001-10-18 | 2003-04-24 | Warner-Lambert Company Llc | Method for preparing purified matrix metalloproteinase |
CA2511521C (en) | 2002-12-30 | 2012-02-07 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
US20050192265A1 (en) * | 2003-03-20 | 2005-09-01 | Thompson Richard C. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
KR101155335B1 (ko) * | 2005-01-07 | 2012-06-11 | 엘지전자 주식회사 | 이동통신 단말기의 멀티미디어 메시지 동작방법 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4743587A (en) * | 1985-09-10 | 1988-05-10 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
US4771038A (en) * | 1986-01-21 | 1988-09-13 | Ici Americas Inc. | Hydroxamic acids |
GB8601368D0 (en) * | 1986-01-21 | 1986-02-26 | Ici America Inc | Hydroxamic acids |
DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
FR2609289B1 (fr) * | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
CA2002021A1 (en) * | 1988-11-03 | 1990-05-03 | Ann E. Aulabaugh | Inhibition of ketol-acid reductoisomerase by oxalylhydroxamate derivatives |
GB8827308D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
GB8827305D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
GB8919251D0 (en) * | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
CA2072018A1 (en) * | 1989-12-16 | 1991-06-17 | Colin Bennion | Pharmacologically active amide carboxylate derivatives |
US5075302A (en) * | 1990-03-09 | 1991-12-24 | Schering Corporation | Mercaptoacyl aminolactam endopeptidase inhibitors |
JPH04217950A (ja) * | 1990-03-28 | 1992-08-07 | Asahi Chem Ind Co Ltd | ヒドロキサム酸誘導体および酵素阻害剤ならびに抗潰瘍剤 |
DE4011172A1 (de) * | 1990-04-06 | 1991-10-10 | Degussa | Verbindungen zur bekaempfung von pflanzenkrankheiten |
US5239078A (en) * | 1990-11-21 | 1993-08-24 | Glycomed Incorporated | Matrix metalloprotease inhibitors |
US5183900A (en) * | 1990-11-21 | 1993-02-02 | Galardy Richard E | Matrix metalloprotease inhibitors |
US5189178A (en) * | 1990-11-21 | 1993-02-23 | Galardy Richard E | Matrix metalloprotease inhibitors |
GB9102635D0 (en) * | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
GB9107368D0 (en) * | 1991-04-08 | 1991-05-22 | Smithkline Beecham Plc | Novel compounds |
IL98681A (en) * | 1991-06-30 | 1997-06-10 | Yeda Rehovot And Dev Company L | Pharmaceutical compositions comprising hydroxamate derivatives for iron removal from mammalian cells and from pathogenic organisms and some novel hydroxamate derivatives |
DE4127842A1 (de) * | 1991-08-22 | 1993-02-25 | Rhone Poulenc Rorer Gmbh | 5-((omega)-arylalky)-2-thienyl alkansaeuren, ihre salze und/oder ihre derivate |
JPH05125029A (ja) * | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
NZ249202A (en) * | 1992-02-20 | 1996-06-25 | Black James Foundation | Bicyclo[2.2.2.]octane derivatives, preparation and pharmaceutical compositions thereof |
US5525629A (en) * | 1992-04-07 | 1996-06-11 | British Bio-Technology Limited | Inhibition of cytokine production |
WO1993021942A2 (en) * | 1992-05-01 | 1993-11-11 | British Biotech Pharmaceuticals Limited | Use of mmp inhibitors |
AU666727B2 (en) * | 1992-06-25 | 1996-02-22 | F. Hoffmann-La Roche Ag | Hydroxamic acid derivatives |
GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
WO1994021612A1 (en) * | 1993-03-18 | 1994-09-29 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives as matrix metalloproteinases inhibitors |
-
1995
- 1995-03-21 US US08/407,839 patent/US5672598A/en not_active Expired - Fee Related
-
1996
- 1996-03-18 IL IL11752796A patent/IL117527A/xx not_active IP Right Cessation
- 1996-03-19 KR KR1019970706554A patent/KR19980703151A/ko active IP Right Grant
- 1996-03-19 AU AU52558/96A patent/AU711889B2/en not_active Ceased
- 1996-03-19 WO PCT/US1996/003726 patent/WO1996029313A1/en active IP Right Grant
- 1996-03-19 AT AT96908856T patent/ATE248150T1/de not_active IP Right Cessation
- 1996-03-19 CZ CZ972951A patent/CZ295197A3/cs unknown
- 1996-03-19 CA CA002216129A patent/CA2216129C/en not_active Expired - Fee Related
- 1996-03-19 JP JP8528560A patent/JPH11502523A/ja not_active Withdrawn
- 1996-03-19 EP EP96908856A patent/EP0815084B1/en not_active Expired - Lifetime
- 1996-03-19 BR BR9607772A patent/BR9607772A/pt not_active Application Discontinuation
- 1996-03-19 DE DE69629670T patent/DE69629670T2/de not_active Expired - Fee Related
- 1996-03-19 NZ NZ304689A patent/NZ304689A/xx unknown
- 1996-03-19 HU HU9800813A patent/HUP9800813A3/hu unknown
- 1996-03-20 ZA ZA962253A patent/ZA962253B/xx unknown
- 1996-03-21 AR ARP960101859A patent/AR002718A1/es unknown
-
1997
- 1997-09-19 NO NO974335A patent/NO974335L/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP0815084B1 (en) | 2003-08-27 |
NO974335D0 (no) | 1997-09-19 |
DE69629670D1 (de) | 2003-10-02 |
DE69629670T2 (de) | 2004-06-17 |
WO1996029313A1 (en) | 1996-09-26 |
NZ304689A (en) | 1999-05-28 |
US5672598A (en) | 1997-09-30 |
ZA962253B (en) | 1996-09-30 |
BR9607772A (pt) | 1998-07-07 |
HUP9800813A3 (en) | 1998-09-28 |
CA2216129A1 (en) | 1996-09-26 |
IL117527A (en) | 1999-12-22 |
EP0815084A1 (en) | 1998-01-07 |
CZ295197A3 (cs) | 1998-05-13 |
AU5255896A (en) | 1996-10-08 |
ATE248150T1 (de) | 2003-09-15 |
AR002718A1 (es) | 1998-04-29 |
CA2216129C (en) | 2002-08-20 |
MX9707214A (es) | 1997-11-29 |
AU711889B2 (en) | 1999-10-21 |
KR19980703151A (ko) | 1998-10-15 |
IL117527A0 (en) | 1996-07-23 |
JPH11502523A (ja) | 1999-03-02 |
NO974335L (no) | 1997-11-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP9800813A2 (hu) | Laktám-tartalmú hidroxámsav-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
HUP9903916A2 (hu) | Foszfinsavamidok és ezeket tartalmazó gyógyszerkészítmények | |
ATE71625T1 (de) | Imidazoheterocyclische verbindungen, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten. | |
ATE28565T1 (de) | Spiro(4.(3+n))-2-aza-alkan-3-carbonsaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung. | |
HUP0100949A2 (hu) | Aril kondenzált azapoliciklusos vegyületek és ezeket tartalmazó gyógyászati készítmények | |
MX9203762A (es) | Administracion de monoaminacridinas en estados deficientes en colinergicos-neuronales. | |
MY102866A (en) | Amide derivatives. | |
BR9807132A (pt) | Derivados de pirrolidina tendo atividade inibitória de fosfolipase a2 | |
AR035455A1 (es) | Derivados triciclicos de alquilhidroxamato , procesos para su elaboracion, composiciones farmaceuticas que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos | |
IL103944A (en) | Piperazine derivatives, their preparation and pharmaceutical compositions containing them | |
HUP0002122A2 (hu) | Ciklusos tio-szubsztituált acilaminosav-amid származékok | |
HUP9802290A2 (hu) | Pirrolszármazékok és az azokat tartalmazó gyógyászati kompozíciók | |
DZ1694A1 (fr) | "n-(2-Aminoethyl)-benzothialozones". | |
MX9203417A (es) | Compuestos de diarilo antiateroescleroticos. | |
HUP0000894A2 (hu) | Szubsztituált (1,3-bisz(ciklohexilmetil)-1,2,3,6-tetrahidro-2,6-dioxo-9H-purin-8-il)fenil-származékok és eljárás előállításukra | |
DK0437128T3 (da) | Anvendelse af et fluorquinolonderivat til fremstilling af et lægemiddel til behandling af pneumocystosis | |
HUP0303105A2 (hu) | Új amino-ciklohexán-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
ATE107298T1 (de) | 3-aminochroman-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
FR2707089B1 (fr) | Nouveaux dérivés d'acide phosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
HUP9904659A2 (hu) | Aril-karbonsav- és tetrazolszármazékok, alkalmazásuk és ezeket tartalmazó gyógyászati készítmények | |
HUP9900668A2 (hu) | Szulfamidsavszármazékok, N-acil-szulfonamidok és szulfonil-karbamát-származékok alkalmazása lipoproteinszintet csökkentő gyógyászati készítmények előállítására | |
HUP0001773A2 (hu) | Szubsztituált tetrahidropiridinszármazékok, eljárás előállításukra, továbbá a vegyületeket tartalmazó gyógyászati készítmények | |
ATE68494T1 (de) | Benzofuranderivate und diese enthaltende therapeutische mittel. | |
DK0853478T3 (da) | Nye N-acylerede 4-hydroxyphenylaminderivater med analgetiske egenskaber samt farmaceutiske sammensætninger indeholdende disse | |
ES8401456A1 (es) | Procedimiento para la preparacion de 2-aminometilfenoles. |