HUP1300623A2 - O-substituted (2r,3r)-3-(3-hidroxiphenil)-2-metyil-4-pentenoic acids and a method of obtaining the same - Google Patents

O-substituted (2r,3r)-3-(3-hidroxiphenil)-2-metyil-4-pentenoic acids and a method of obtaining the same

Info

Publication number
HUP1300623A2
HUP1300623A2 HU1300623A HUP1300623A HUP1300623A2 HU P1300623 A2 HUP1300623 A2 HU P1300623A2 HU 1300623 A HU1300623 A HU 1300623A HU P1300623 A HUP1300623 A HU P1300623A HU P1300623 A2 HUP1300623 A2 HU P1300623A2
Authority
HU
Hungary
Prior art keywords
metyil
hidroxiphenil
substituted
obtaining
same
Prior art date
Application number
HU1300623A
Other languages
Hungarian (hu)
Inventor
Ru Ena Vlasakova
Josef Hajicek
Josef Zezula
Original Assignee
Zentiva Ks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CZ20100995A external-priority patent/CZ303115B6/en
Priority claimed from CZ20100998A external-priority patent/CZ302993B6/en
Priority claimed from CZ20100996A external-priority patent/CZ303116B6/en
Application filed by Zentiva Ks filed Critical Zentiva Ks
Publication of HUP1300623A2 publication Critical patent/HUP1300623A2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/02Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41Preparation of salts of carboxylic acids
    • C07C51/412Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • C07C51/43Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58Preparation of carboxylic acid halides
    • C07C51/60Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
HU1300623A 2010-12-30 2011-12-30 O-substituted (2r,3r)-3-(3-hidroxiphenil)-2-metyil-4-pentenoic acids and a method of obtaining the same HUP1300623A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CZ20100995A CZ303115B6 (en) 2010-12-30 2010-12-30 Process for preparing (2R,3R)-N,N-dimethyl-3-(3-hydroxyphenyl)-2-methylpentylamine
CZ20100998A CZ302993B6 (en) 2010-12-30 2010-12-30 Process for preparing (2R,3R)-N,N-dimethyl-3-(hydroxyphenyl)-2-methylpentylamine (tapentadol)
CZ20100996A CZ303116B6 (en) 2010-12-30 2010-12-30 Process for preparing O-substituted (2R,3R)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids
PCT/CZ2011/000128 WO2012089181A1 (en) 2010-12-30 2011-12-30 O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same

Publications (1)

Publication Number Publication Date
HUP1300623A2 true HUP1300623A2 (en) 2014-03-28

Family

ID=45606889

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1300623A HUP1300623A2 (en) 2010-12-30 2011-12-30 O-substituted (2r,3r)-3-(3-hidroxiphenil)-2-metyil-4-pentenoic acids and a method of obtaining the same

Country Status (2)

Country Link
HU (1) HUP1300623A2 (en)
WO (1) WO2012089181A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102924303B (en) * 2012-10-31 2013-11-20 合肥市新星医药化工有限公司 Tapentadol hydrochloride crystal form C, and preparation method and application thereof
ES2940904T3 (en) * 2014-07-10 2023-05-12 SpecGx LLC Procedure for preparing substituted phenylalkanes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10326097A1 (en) * 2003-06-06 2005-01-05 Grünenthal GmbH Process for the preparation of dimethyl (3-aryl-butyl) -amine compounds
DE102005052588A1 (en) * 2005-11-02 2007-05-10 Grünenthal GmbH Process for the preparation of substituted dimethyl- (3-aryl-butyl) -amine compounds by means of homogeneous catalysis
TWI401237B (en) * 2006-07-24 2013-07-11 Preparation of 3-[(1r, 2r)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride
PT2046726E (en) * 2006-07-24 2010-04-15 Janssen Pharmaceutica Nv Preparation of (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpentanamine

Also Published As

Publication number Publication date
WO2012089181A1 (en) 2012-07-05

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees