HUP0600120A2 - New crystalline atorvastatin hemicalcium, pharmaceutical composition containing it and process for producing it - Google Patents
New crystalline atorvastatin hemicalcium, pharmaceutical composition containing it and process for producing itInfo
- Publication number
- HUP0600120A2 HUP0600120A2 HU0600120A HUP0600120A HUP0600120A2 HU P0600120 A2 HUP0600120 A2 HU P0600120A2 HU 0600120 A HU0600120 A HU 0600120A HU P0600120 A HUP0600120 A HU P0600120A HU P0600120 A2 HUP0600120 A2 HU P0600120A2
- Authority
- HU
- Hungary
- Prior art keywords
- producing
- pharmaceutical composition
- composition containing
- new crystalline
- atorvastatin hemicalcium
- Prior art date
Links
- FQCKMBLVYCEXJB-MNSAWQCASA-L atorvastatin calcium Chemical compound [Ca+2].C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1.C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 FQCKMBLVYCEXJB-MNSAWQCASA-L 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 102100029077 3-hydroxy-3-methylglutaryl-coenzyme A reductase Human genes 0.000 abstract 1
- 101710158485 3-hydroxy-3-methylglutaryl-coenzyme A reductase Proteins 0.000 abstract 1
- 229940123934 Reductase inhibitor Drugs 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 230000002402 anti-lipaemic effect Effects 0.000 abstract 1
- 239000012752 auxiliary agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Crystalline polymorph B-52 form of atorvastatin hemicalcium salt [(beta R, delta R)-2-(4-fluorophenyl)-beta ,delta -dihydroxy-5-(1-methylethyl)-3-phenyl-4-{(phenylamino)-carbonyl}-1H-pyrrole-1-heptanoic acid hemicalcium salt] (I) and its solvates having an X-ray diffraction pattern is new. Independent claims are also included for the following: (1) preparation of (I); and (2) medicinal preparations (M1) comprising (I) and vehicles or auxiliary agents. ACTIVITY : Antilipemic. MECHANISM OF ACTION : 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor.
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0600120A HUP0600120A3 (en) | 2006-02-14 | 2006-02-14 | New crystalline atorvastatin hemicalcium, pharmaceutical composition containing it and process for producing it |
EP06727218.7A EP1868993B1 (en) | 2005-04-08 | 2006-04-07 | Process for the preparation of a new crystalline atorvastatin hemicalcium salt polymorph form |
PCT/HU2006/000026 WO2006106372A1 (en) | 2005-04-08 | 2006-04-07 | New crystalline atorvastatin hemicalcium salt polymorph form |
CZ20070772A CZ2007772A3 (en) | 2005-04-08 | 2006-04-07 | Novel crystalline polymorphous form of atorvastatin hemicalcium salt |
ROA200700700A RO123642B1 (en) | 2005-04-08 | 2006-04-07 | Process for preparing a new crystalline atorvastatin hemicalcium salt polymorph form |
JP2008504860A JP5523699B2 (en) | 2005-04-08 | 2006-04-07 | A new crystalline polymorph of atorvastatin hemi-calcium salt |
EA200702191A EA014079B1 (en) | 2005-04-08 | 2006-04-07 | New crystalline atorvastatin hemicalcium salt polymorph form |
US11/887,890 US20090215855A1 (en) | 2005-04-08 | 2006-04-07 | New Crystalline Atorvastatin Hemicalcium Salt Polymorph Form |
RU2007140797/04A RU2409563C2 (en) | 2005-04-08 | 2006-04-07 | Novel polymorphous form of crystalline hemicalcium salt of atorvastatin |
SK5125-2007A SK288276B6 (en) | 2005-04-08 | 2006-04-07 | Process for preparation of crystalline atorvastatin hemicalcium salt polymorph form |
IL186499A IL186499A (en) | 2005-04-08 | 2007-10-08 | Processes for the preparation of crystalline atorvastatin hemicalcium form |
NO20075721A NO20075721L (en) | 2005-04-08 | 2007-11-08 | New crystalline atorvastatin hemicalcium salt polymorph form |
BG10109992A BG66035B1 (en) | 2005-04-08 | 2007-11-08 | New crystalline atorvastatin hemicalcium salt polymorph form |
HK08105767.2A HK1117141A1 (en) | 2005-04-08 | 2008-05-23 | Process for the preparation of a new crystalline atorvastatin hemicalcium salt polymorph form |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0600120A HUP0600120A3 (en) | 2006-02-14 | 2006-02-14 | New crystalline atorvastatin hemicalcium, pharmaceutical composition containing it and process for producing it |
Publications (3)
Publication Number | Publication Date |
---|---|
HU0600120D0 HU0600120D0 (en) | 2006-04-28 |
HUP0600120A2 true HUP0600120A2 (en) | 2007-09-28 |
HUP0600120A3 HUP0600120A3 (en) | 2010-01-28 |
Family
ID=89986584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0600120A HUP0600120A3 (en) | 2005-04-08 | 2006-02-14 | New crystalline atorvastatin hemicalcium, pharmaceutical composition containing it and process for producing it |
Country Status (1)
Country | Link |
---|---|
HU (1) | HUP0600120A3 (en) |
-
2006
- 2006-02-14 HU HU0600120A patent/HUP0600120A3/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU0600120D0 (en) | 2006-04-28 |
HUP0600120A3 (en) | 2010-01-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |