HUP0500034A2 - N-Aril-N'-(aril-cikloalkil)-karbamid-származékok mint MCH antagonisták és ezeket hatóanyagként tartalmazó gyógyszerkészítmények - Google Patents

N-Aril-N'-(aril-cikloalkil)-karbamid-származékok mint MCH antagonisták és ezeket hatóanyagként tartalmazó gyógyszerkészítmények

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Publication number
HUP0500034A2
HUP0500034A2 HU0500034A HUP0500034A HUP0500034A2 HU P0500034 A2 HUP0500034 A2 HU P0500034A2 HU 0500034 A HU0500034 A HU 0500034A HU P0500034 A HUP0500034 A HU P0500034A HU P0500034 A2 HUP0500034 A2 HU P0500034A2
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HU
Hungary
Prior art keywords
optionally
group
aryl
arylcycloalkyl
pharmaceutical compositions
Prior art date
Application number
HU0500034A
Other languages
English (en)
Inventor
John W. Clader
Anandan Palani
Ruo Xu
Mark D. Mcbriar
Jing Su
Haiqun Tang
Original Assignee
Schering Corporation
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Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of HUP0500034A2 publication Critical patent/HUP0500034A2/hu

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms

Abstract

A találmány tárgyát általános képletű vegyületek - ahol Ar1 és Ar2adott esetben szubsztituált aril- vagy heteroarilcsoport; X oxigén-,kénatom vagy ciano-imino-csoport; Y egyes kötés vagy alkiléncsoport; Zadott esetben egy vagy két kettős kötést tartalmazó és adott esetbenlegfeljebb négyszeresen szubsztituált cikloalkilén vagyheterocikloalkilén-csoport; R1 adott esetben szubsztituált aril-,heteroaril-, cikloalkil-, heterocikloalkil-, különféleképpszubsztituált aminocsoport; R2 hidrogénatom vagy alkilcsoport - ésgyógyszerészetileg elfogadható sóik vagy szolvátjaik, ezekettartalmazó gyógyszerkészítmények és előállításuk képezik. A találmányszerinti vegyületek a melanin-koncentráló hormon (MCH) újantagonistái, és elhízás, anyagcsere-rendellenességek, étkezésirendellenességek, például hyperphagia és diabétesz kezelésére szolgálógyógyszerkészítmények hatóanyagaiként alkalmazhatók. Ó
HU0500034A 2001-12-04 2002-12-03 N-Aril-N'-(aril-cikloalkil)-karbamid-származékok mint MCH antagonisták és ezeket hatóanyagként tartalmazó gyógyszerkészítmények HUP0500034A2 (hu)

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PCT/US2002/038408 WO2003047568A1 (en) 2001-12-04 2002-12-03 N-aryl-n'-arylcycloalkyl-urea derivatives as mch antagonists for the treatment of obesity

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JP4330996B2 (ja) 2009-09-16
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EP1453501A1 (en) 2004-09-08
WO2003047568A1 (en) 2003-06-12
JP2009235076A (ja) 2009-10-15
IL162311A0 (en) 2005-11-20
MXPA04005503A (es) 2004-12-06
US20040122017A1 (en) 2004-06-24
PE20030680A1 (es) 2003-08-11
DE60228317D1 (de) 2008-09-25
US7348328B2 (en) 2008-03-25
ATE404190T1 (de) 2008-08-15
CN1617718A (zh) 2005-05-18
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AR037621A1 (es) 2004-11-17
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