HUP0402639A3 - Antitumor combination comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors and its use - Google Patents

Antitumor combination comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors and its use

Info

Publication number: HUP0402639A3
Authority: HU; Hungary
Prior art keywords: serine; inhibitors; kinase; distamycin derivatives; protein kinase
Prior art date: 2002-01-02

Application number

HU0402639A

Other languages

English (en)

Original Assignee

Nerviano Medical Sciences Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-02

Filing date

2002-12-18

Publication date

2012-02-28

2002-12-18 Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl

2005-04-28 Publication of HUP0402639A2 publication Critical patent/HUP0402639A2/hu

2012-02-28 Publication of HUP0402639A3 publication Critical patent/HUP0402639A3/hu

Links

101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 title 1
102000001253 Protein Kinase Human genes 0.000 title 1
102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 title 1
-1 acryloyl distamycin derivatives Chemical class 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
108060006633 protein kinase Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

HU0402639A 2002-01-02 2002-12-18 Antitumor combination comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors and its use HUP0402639A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02075052		2002-01-02
PCT/EP2002/013092 WO2003055522A1 (en)	2002-01-02	2002-12-18	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors

Publications (2)

Publication Number	Publication Date
HUP0402639A2 HUP0402639A2 (hu)	2005-04-28
HUP0402639A3 true HUP0402639A3 (en)	2012-02-28

Family

ID=8185508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0402639A HUP0402639A3 (en)	2002-01-02	2002-12-18	Antitumor combination comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors and its use

Country Status (24)

Country	Link
US (1)	US20060084612A1 (hu)
EP (1)	EP1461083B1 (hu)
JP (1)	JP2005516025A (hu)
KR (1)	KR20040078118A (hu)
CN (1)	CN1617744A (hu)
AT (1)	ATE321572T1 (hu)
AU (1)	AU2002352090B8 (hu)
BR (1)	BR0215454A (hu)
CA (1)	CA2472008C (hu)
CY (1)	CY1105269T1 (hu)
DE (1)	DE60210329T2 (hu)
DK (1)	DK1461083T3 (hu)
ES (1)	ES2263835T3 (hu)
HU (1)	HUP0402639A3 (hu)
IL (2)	IL162820A0 (hu)
MX (1)	MXPA04006543A (hu)
NO (1)	NO20043217L (hu)
NZ (1)	NZ533854A (hu)
PL (1)	PL371179A1 (hu)
PT (1)	PT1461083E (hu)
RU (1)	RU2328306C2 (hu)
SI (1)	SI1461083T1 (hu)
WO (1)	WO2003055522A1 (hu)
ZA (1)	ZA200405290B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101066804B1 (ko) *	2002-07-30	2011-09-22	아에테르나 젠타리스 게엠베하	항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품
US8383605B2 (en)	2002-07-30	2013-02-26	Aeterna Zentaris Gmbh	Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
EA011574B1 (ru) *	2005-04-08	2009-04-28	НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л.	Противораковая комбинация, содержащая производные замещённого акрилоилдистамицина и антитела, ингибирующие факторы роста или их рецепторы
MX2011011596A (es)	2010-03-31	2012-02-01	Keryx Biopharmaceuticals Inc	Perifosina y capecitabina como un tratamiento combinado para cancer.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6274576B1 (en) *	1995-06-27	2001-08-14	The Henry Jackson Foundation For The Advancement Of Military Medicine	Method of dynamic retardation of cell cycle kinetics to potentiate cell damage
GB9615692D0 (en) *	1996-07-25	1996-09-04	Pharmacia Spa	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB0015447D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015444D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors

2002
- 2002-12-18 KR KR10-2004-7010472A patent/KR20040078118A/ko not_active Application Discontinuation
- 2002-12-18 SI SI200230335T patent/SI1461083T1/sl unknown
- 2002-12-18 DK DK02787763T patent/DK1461083T3/da active
- 2002-12-18 DE DE60210329T patent/DE60210329T2/de not_active Expired - Lifetime
- 2002-12-18 HU HU0402639A patent/HUP0402639A3/hu unknown
- 2002-12-18 US US10/500,606 patent/US20060084612A1/en not_active Abandoned
- 2002-12-18 MX MXPA04006543A patent/MXPA04006543A/es active IP Right Grant
- 2002-12-18 AT AT02787763T patent/ATE321572T1/de active
- 2002-12-18 AU AU2002352090A patent/AU2002352090B8/en not_active Ceased
- 2002-12-18 WO PCT/EP2002/013092 patent/WO2003055522A1/en active IP Right Grant
- 2002-12-18 PL PL02371179A patent/PL371179A1/xx not_active Application Discontinuation
- 2002-12-18 JP JP2003556098A patent/JP2005516025A/ja active Pending
- 2002-12-18 EP EP02787763A patent/EP1461083B1/en not_active Expired - Lifetime
- 2002-12-18 RU RU2004123641/15A patent/RU2328306C2/ru not_active IP Right Cessation
- 2002-12-18 ES ES02787763T patent/ES2263835T3/es not_active Expired - Lifetime
- 2002-12-18 CN CNA028276744A patent/CN1617744A/zh active Pending
- 2002-12-18 IL IL16282002A patent/IL162820A0/xx unknown
- 2002-12-18 CA CA002472008A patent/CA2472008C/en not_active Expired - Fee Related
- 2002-12-18 BR BR0215454-4A patent/BR0215454A/pt not_active IP Right Cessation
- 2002-12-18 NZ NZ533854A patent/NZ533854A/en not_active IP Right Cessation
- 2002-12-18 PT PT02787763T patent/PT1461083E/pt unknown
2004
- 2004-07-01 IL IL162820A patent/IL162820A/en not_active IP Right Cessation
- 2004-07-02 ZA ZA200405290A patent/ZA200405290B/xx unknown
- 2004-07-29 NO NO20043217A patent/NO20043217L/no not_active Application Discontinuation
2006
- 2006-06-05 CY CY20061100717T patent/CY1105269T1/el unknown

Also Published As

Publication number	Publication date
IL162820A (en)	2010-04-15
DK1461083T3 (da)	2006-07-10
NO20043217L (no)	2004-07-30
CY1105269T1 (el)	2010-03-03
RU2328306C2 (ru)	2008-07-10
PL371179A1 (en)	2005-06-13
KR20040078118A (ko)	2004-09-08
SI1461083T1 (sl)	2006-08-31
ZA200405290B (en)	2005-06-17
PT1461083E (pt)	2006-08-31
AU2002352090B8 (en)	2008-06-19
DE60210329T2 (de)	2006-11-30
HUP0402639A2 (hu)	2005-04-28
DE60210329D1 (de)	2006-05-18
EP1461083A1 (en)	2004-09-29
BR0215454A (pt)	2004-11-23
JP2005516025A (ja)	2005-06-02
ATE321572T1 (de)	2006-04-15
IL162820A0 (en)	2005-11-20
CA2472008A1 (en)	2003-07-10
CA2472008C (en)	2009-07-28
US20060084612A1 (en)	2006-04-20
MXPA04006543A (es)	2004-10-04
ES2263835T3 (es)	2006-12-16
EP1461083B1 (en)	2006-03-29
WO2003055522A1 (en)	2003-07-10
AU2002352090A1 (en)	2003-07-15
AU2002352090B2 (en)	2008-05-15
NZ533854A (en)	2007-05-31
CN1617744A (zh)	2005-05-18
RU2004123641A (ru)	2005-06-10

Legal Events

Date

Code

Title

Description

2008-11-28

GB9A

Succession in title

Owner name: NERVIANO MEDICAL SCIENCES S.R.L., IT

Free format text: FORMER OWNER(S): PHARMACIA ITALIA S.P.A., IT

2012-09-28

FD9A

Lapse of provisional protection due to non-payment of fees

Publication	Publication Date	Title
PL376789A1 (pl)	2006-01-09	Pochodne aminoindazoli i ich zastosowanie jako inhibitorów kinazy
PL375447A1 (en)	2005-11-28	Protein kinase inhibitors and uses thereof
IL176233A0 (en)	2006-10-05	Organophosphorous indazole derivatives and use thereof as protein kinase inhibitors
AU2003259749A1 (en)	2004-02-25	3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
SI2305250T1 (sl)	2014-06-30	Benzimidazolni derivati in njih uporabo kot inhibitorji protein-kinaz
IL165515A0 (en)	2006-01-15	Bisindolyl-maleimid derivatives as kinase inhibitors
AU2003299651A1 (en)	2004-06-30	Tyrosine kinase inhibitors
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HK1061854A1 (en)	2004-10-08	Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
IL161516A0 (en)	2004-09-27	Benzimidazoles useful as protein kinase inhibitors
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EP1534268A4 (en)	2006-11-02	TYROSINE KINASE INHIBITORS
IL172257A0 (en)	2011-08-01	Substituted pyrrole derivatives and their use as hmg-co inhibitors
AU2002953255A0 (en)	2003-01-02	Protein kinase inhibitors
AU2003220437A1 (en)	2003-10-08	Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
HK1077520A1 (zh)	2006-02-17	用作p38促細胞***原活化蛋白激酶抑制劑的吲哚類衍生物
PL374581A1 (en)	2005-10-31	Diaminothiazoles and use thereof as cdk4 inhibitors
EP1496897A4 (en)	2006-05-10	INHIBITORS OF TYROSINE KINASES
AU2003210983A1 (en)	2003-09-04	Kinase inhibitors and methods of use thereof
AUPS251502A0 (en)	2002-06-13	Protein kinase inhibitors
HUP0402639A3 (en)	2012-02-28	Antitumor combination comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors and its use