HUP0401468A2 - Aminoquinoline derivatives and process for producing them - Google Patents

Aminoquinoline derivatives and process for producing them

Info

Publication number
HUP0401468A2
HUP0401468A2 HU0401468A HUP0401468A HUP0401468A2 HU P0401468 A2 HUP0401468 A2 HU P0401468A2 HU 0401468 A HU0401468 A HU 0401468A HU P0401468 A HUP0401468 A HU P0401468A HU P0401468 A2 HUP0401468 A2 HU P0401468A2
Authority
HU
Hungary
Prior art keywords
alkyl
cycloalkyl
solvates
halo
alkoxy
Prior art date
Application number
HU0401468A
Other languages
Hungarian (hu)
Inventor
Sandor Dr Batori
Geza Dr Timari
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Priority to HU0401468A priority Critical patent/HUP0401468A3/en
Priority to PT04769079T priority patent/PT1663982E/en
Priority to NZ545580A priority patent/NZ545580A/en
Priority to BRPI0412577-0A priority patent/BRPI0412577A/en
Priority to CA2534105A priority patent/CA2534105C/en
Priority to SI200430575T priority patent/SI1663982T1/en
Priority to PL04769079T priority patent/PL1663982T3/en
Priority to CN2008100096757A priority patent/CN101239945B/en
Priority to KR1020067002148A priority patent/KR20060065662A/en
Priority to EP04769079A priority patent/EP1663982B1/en
Priority to DE602004010284T priority patent/DE602004010284T2/en
Priority to MEP-191/08A priority patent/MEP19108A/en
Priority to PCT/HU2004/000080 priority patent/WO2005009969A1/en
Priority to DK04769079T priority patent/DK1663982T3/en
Priority to MXPA06001254A priority patent/MXPA06001254A/en
Priority to YUP-2006/0072A priority patent/RS20060072A/en
Priority to JP2006521678A priority patent/JP2007500689A/en
Priority to AU2004259127A priority patent/AU2004259127B2/en
Priority to ES04769079T priority patent/ES2295923T3/en
Priority to ARP040102713A priority patent/AR045326A1/en
Priority to TW093122807A priority patent/TW200510320A/en
Publication of HUP0401468D0 publication Critical patent/HUP0401468D0/en
Priority to IL173416A priority patent/IL173416A/en
Priority to US11/344,440 priority patent/US7547696B2/en
Priority to NO20060702A priority patent/NO20060702L/en
Priority to MA28810A priority patent/MA27991A1/en
Priority to HK06108521A priority patent/HK1088261A1/en
Publication of HUP0401468A2 publication Critical patent/HUP0401468A2/en
Priority to HR20070584T priority patent/HRP20070584T3/en
Priority to CY20081100135T priority patent/CY1107875T1/en
Publication of HUP0401468A3 publication Critical patent/HUP0401468A3/en
Priority to US12/484,658 priority patent/US7799922B2/en
Priority to US12/854,355 priority patent/US20110009626A1/en
Priority to US13/008,398 priority patent/US8071601B2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Aminoquinoline derivatives (I) and their salts, solvates, isomers (tautomers, desmotrops, optically active isomers) and their salts or solvates are new. Aminoquinoline derivatives of formula (I) and their salts, solvates, isomers (tautomers, desmotrops, optically active isomers) and their salts or solvates are new. [Image] R 1>H or 1-4C alkyl; R 2>H or 1-4C alkyl; R 3>H, 1-4C alkyl, 3-6C cycloalkyl, phenyl, thienyl or furyl (optionally substituted by 1-4C alkyl, 1-4C alkoxy or halo), 5-6 membered heteroaromatic ring containing 1-3N, 5 membered heteroaromatic ring containing O, N or S (optionally substituted with 1-4C alkyl, 1-4C alkoxy or halo); R 4>, R 5>H, 3-6C cycloalkyl or 1-4C alkyl (optionally containing amino group substituted by 1-2 1-4C alkyl, OH, carboxy or alkyl group substituted with 1-4C alkyl), benzyl, -SO 2OH or 1-4C acyl; NR 4>R 5>a group of formula (a); R 7>, R 8>H, 1-4C alkyl or 3-6C cycloalkyl; R 6>H, 1-4C alkyl, phenyl, benzyl, thienyl or furyl (optionally substituted by methylenedioxy or 1 or more 1-4C alkyl, 1-4C alkoxy, hydroxy, trifluoromethyl, cyano or halo), or 5 or 6 membered heteroaromatic ring (containing either 1-3 N, 1 N and 1 O or 1 N and 1 S, and optionally substituted by 1 or more 1-4C alkyl, 1-4C alkoxy or halo); X : CH 2, NH, NR 9>, S, O, sulfo or sulfoxy; R 9>1-4C alkyl or 3-6C cycloalkyl; Z : O, S, CHR 1> 0> or NR 1>; R 1> 0>H, 1-4C alkyl or 3-6C cycloalkyl; R 1> 1>H, 1-4C alkyl, 3-6C cycloalkyl, SO 2OH or 1-4C acyl; n : 0-2; m, o : 1-3; and p, r : 0-1. Provided that either: (1) R 4> and R 5> are H, 3-6C cycloalkyl or 1-4C alkyl optionally contains amino group substituted 1-2 1-4C alkyl, OH, carboxy or alkyl group substituted with 1-4C alkyl; (2) R 4> is H, 1-4C alkyl or benzyl and R 5> is H, -SO 2OH or 1-4C acyl; or (3) NR 4>R 5> is (a). [Image] Independent claims are also included for the following: (1) preparation of (I); and (2) new compounds of formulae (II''), (III''), (IV''), (V''), (VI''), (VII''), (VIII'') and (XIII''). [Image] ACTIVITY : Cardiant; Nephrotropic; Respiratory-Gen.; CNS-Gen.; Cytostatic; Ophthalmological; Antiinflammatory; Antiasthmatic; Vasotropic; Antidepressant; Antiarrhythmic; Antiparkinsonian; Nootropic; Antiallergic; Dermatological; Antiarthritic; Immunosuppressive; Gastrointestinal-Gen.; Anabolic; Hypertensive; Antipsoriatic; Antirheumatic; Neuroprotective; Antidiabetic. MECHANISM OF ACTION : Adenosine A3 ligands. (I) were tested for adenosine A3 ligand activity in HEK-293 cells. The inhibitory constant value of (I) was 0.5-15 nM.
HU0401468A 2003-07-31 2004-07-21 Aminoquinoline derivatives and process for producing them HUP0401468A3 (en)

Priority Applications (31)

Application Number Priority Date Filing Date Title
HU0401468A HUP0401468A3 (en) 2004-07-21 2004-07-21 Aminoquinoline derivatives and process for producing them
YUP-2006/0072A RS20060072A (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands
ES04769079T ES2295923T3 (en) 2003-07-31 2004-07-23 DERIVATIVES OF AMINOQUINOLINE AND ITS USE AS LEGANDS OF ADENOSINE A3.
BRPI0412577-0A BRPI0412577A (en) 2003-07-31 2004-07-23 aminoquinoline derivatives and their use as a3 adenosine binders
AU2004259127A AU2004259127B2 (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine A3 ligands
SI200430575T SI1663982T1 (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands
PL04769079T PL1663982T3 (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands
CN2008100096757A CN101239945B (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands
NZ545580A NZ545580A (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine A3 ligands
EP04769079A EP1663982B1 (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands
DE602004010284T DE602004010284T2 (en) 2003-07-31 2004-07-23 AMINOCHINOLINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS
MEP-191/08A MEP19108A (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands
PCT/HU2004/000080 WO2005009969A1 (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands
DK04769079T DK1663982T3 (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine A3 ligands
MXPA06001254A MXPA06001254A (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands.
PT04769079T PT1663982E (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands
JP2006521678A JP2007500689A (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine A3 ligands
CA2534105A CA2534105C (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands
KR1020067002148A KR20060065662A (en) 2003-07-31 2004-07-23 Aminoquinoline derivatives and their use as adenosine a3 ligands
TW093122807A TW200510320A (en) 2003-07-31 2004-07-30 Aminoquinoline derivatives and their use as adenosine A3 ligands
ARP040102713A AR045326A1 (en) 2003-07-31 2004-07-30 AMINOQUINOLINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS
IL173416A IL173416A (en) 2003-07-31 2006-01-29 Aminoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and uses thereof in the preparation of pharmaceutical compositions
US11/344,440 US7547696B2 (en) 2003-07-31 2006-01-31 Aminoquinoline derivatives and their use as adenosine A3 ligands
NO20060702A NO20060702L (en) 2003-07-31 2006-02-14 Aminoquinoline derivatives and their use as adenosine A3 ligands
MA28810A MA27991A1 (en) 2003-07-31 2006-02-15 AMINOQUINOLINE DERIVATIVES AND THEIR USE AS LIGANDS OF ADENOSINE A3
HK06108521A HK1088261A1 (en) 2003-07-31 2006-08-01 Aminoquinoline derivatives and their use as adenosine a3 ligands
HR20070584T HRP20070584T3 (en) 2003-07-31 2007-12-28 Aminoquinoline derivatives and their use as adenosine a3 ligands
CY20081100135T CY1107875T1 (en) 2003-07-31 2008-02-04 AMINOCINOLIN PRODUCTS AND THEIR USE AS A3 ADENOSIN CONNECTORS
US12/484,658 US7799922B2 (en) 2003-07-31 2009-06-15 Aminoquinoline derivatives and their use as adenosine A3 ligands
US12/854,355 US20110009626A1 (en) 2003-07-31 2010-08-11 Aminoquinoline derivatives and their use as adenosine a3 ligands
US13/008,398 US8071601B2 (en) 2003-07-31 2011-01-18 Aminoquinoline derivatives and their use as adenosine A3 ligands

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0401468A HUP0401468A3 (en) 2004-07-21 2004-07-21 Aminoquinoline derivatives and process for producing them

Publications (3)

Publication Number Publication Date
HUP0401468D0 HUP0401468D0 (en) 2004-09-28
HUP0401468A2 true HUP0401468A2 (en) 2006-09-28
HUP0401468A3 HUP0401468A3 (en) 2008-03-28

Family

ID=90014239

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401468A HUP0401468A3 (en) 2003-07-31 2004-07-21 Aminoquinoline derivatives and process for producing them

Country Status (1)

Country Link
HU (1) HUP0401468A3 (en)

Also Published As

Publication number Publication date
HUP0401468D0 (en) 2004-09-28
HUP0401468A3 (en) 2008-03-28

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished