HUP0303563A2 - Estrogen receptor modulators - Google Patents
Estrogen receptor modulatorsInfo
- Publication number
- HUP0303563A2 HUP0303563A2 HU0303563A HUP0303563A HUP0303563A2 HU P0303563 A2 HUP0303563 A2 HU P0303563A2 HU 0303563 A HU0303563 A HU 0303563A HU P0303563 A HUP0303563 A HU P0303563A HU P0303563 A2 HUP0303563 A2 HU P0303563A2
- Authority
- HU
- Hungary
- Prior art keywords
- estrogen receptor
- compounds
- receptor modulators
- uterine
- estrogen
- Prior art date
Links
- 239000002834 estrogen receptor modulator Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 208000014644 Brain disease Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000004145 Endometritis Diseases 0.000 abstract 1
- 208000033830 Hot Flashes Diseases 0.000 abstract 1
- 206010060800 Hot flush Diseases 0.000 abstract 1
- 206010021639 Incontinence Diseases 0.000 abstract 1
- 238000008214 LDL Cholesterol Methods 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000002495 Uterine Neoplasms Diseases 0.000 abstract 1
- 206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 102000015694 estrogen receptors Human genes 0.000 abstract 1
- 108010038795 estrogen receptors Proteins 0.000 abstract 1
- 201000000079 gynecomastia Diseases 0.000 abstract 1
- 201000010260 leiomyoma Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 206010046766 uterine cancer Diseases 0.000 abstract 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 abstract 1
- 201000007954 uterine fibroid Diseases 0.000 abstract 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
Abstract
A találmány olyan vegyületekre és származékaikra valamintelőállításukra és alkalmazásukra vonatkozik, amelyeketösztrogénreceptor modulátorként lehet használni. A találmány szerintivegyületek ösztrogénreceptor ligandumok, és hasznosak különböző,ösztrogénműködéssel kapcsolatos betegségek megelőzésénél éskezelésénél. Ilyenek a csontveszteség, csonttörés, csontritkulás,porckopás, méhbelhártya-gyulladás, méh-fibroidbetegség, hőhullámok,megnövelt LDL koleszterinszint, szív-érrendszeri betegség, tanulásifunkciók megromlása, agyi degeneratív rendellenességek, resztenózis,ginekomasztia, ér-simaizomsejt-burjánzás, elhízás, inkontinencia, rák,különösen emlő-, méh- és prosztatarák. ÓThe invention relates to compounds and their derivatives, as well as their preparation and use, which can be used as estrogen receptor modulators. The compounds of the invention are estrogen receptor ligands and are useful in the prevention and treatment of various diseases related to estrogen action. These include bone loss, bone fracture, osteoporosis, cartilage wear, endometritis, uterine fibroid disease, hot flashes, increased LDL cholesterol level, cardiovascular disease, impairment of learning functions, degenerative brain disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, cancer, especially breast, uterine and prostate cancer. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24158200P | 2000-10-19 | 2000-10-19 | |
| PCT/US2001/042735 WO2002032377A2 (en) | 2000-10-19 | 2001-10-15 | Estrogen receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0303563A2 true HUP0303563A2 (en) | 2004-03-01 |
Family
ID=22911282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303563A HUP0303563A2 (en) | 2000-10-19 | 2001-10-15 | Estrogen receptor modulators |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1333827A2 (en) |
| JP (1) | JP2004511502A (en) |
| KR (1) | KR20030042020A (en) |
| CN (1) | CN1469743A (en) |
| AU (2) | AU2002232381B2 (en) |
| BG (1) | BG107676A (en) |
| BR (1) | BR0114689A (en) |
| CA (1) | CA2424729A1 (en) |
| EA (1) | EA200300474A1 (en) |
| EC (1) | ECSP034558A (en) |
| EE (1) | EE200300153A (en) |
| HU (1) | HUP0303563A2 (en) |
| IL (1) | IL154984A0 (en) |
| IS (1) | IS6761A (en) |
| MX (1) | MXPA03003485A (en) |
| NO (1) | NO20031737L (en) |
| PE (1) | PE20021083A1 (en) |
| PL (1) | PL361053A1 (en) |
| SK (1) | SK4772003A3 (en) |
| WO (1) | WO2002032377A2 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030225132A1 (en) * | 2002-04-11 | 2003-12-04 | Dininno Frank P. | Estrogen receptor modulators |
| ES2350446T3 (en) * | 2002-04-24 | 2011-01-24 | MERCK SHARP & DOHME CORP. | MODULATORS OF ESTROGEN RECEIVERS. |
| CA2512000C (en) * | 2002-12-26 | 2011-08-09 | Eisai Co., Ltd. | Selective estrogen receptor modulator |
| AU2006275514B2 (en) * | 2005-07-29 | 2012-04-05 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| AU2006307046A1 (en) | 2005-10-27 | 2007-05-03 | Msd K.K. | Novel benzoxathiin derivative |
| CN101641339B (en) | 2007-02-01 | 2013-07-17 | 雷斯韦洛吉克斯公司 | Compounds for the prevention and treatment of cardiovascular diseases |
| AU2010204106B2 (en) | 2009-01-08 | 2014-05-08 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| MX2021012876A (en) | 2009-03-18 | 2022-06-23 | Resverlogix Corp | Novel anti-inflammatory agents. |
| ES2821018T3 (en) | 2009-04-22 | 2021-04-23 | Resverlogix Corp | New anti-inflammatory agents |
| CN102939287B (en) | 2010-06-10 | 2016-01-27 | 塞拉根制药公司 | Estrogenic agents and uses thereof |
| US8853423B2 (en) | 2010-06-17 | 2014-10-07 | Seragon Pharmaceuticals, Inc. | Indane estrogen receptor modulators and uses thereof |
| PT2773354T (en) | 2011-11-01 | 2019-07-17 | Resverlogix Corp | Oral immediate release formulations for substituted quinazolinones |
| US9193714B2 (en) | 2011-12-14 | 2015-11-24 | Seragon Pharmaceuticals, Inc. | Fluorinated estrogen receptor modulators and uses thereof |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| AU2013365926B9 (en) | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
| US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
-
2001
- 2001-10-15 CN CNA018176720A patent/CN1469743A/en active Pending
- 2001-10-15 KR KR10-2003-7005518A patent/KR20030042020A/en not_active Application Discontinuation
- 2001-10-15 EE EEP200300153A patent/EE200300153A/en unknown
- 2001-10-15 JP JP2002535616A patent/JP2004511502A/en not_active Withdrawn
- 2001-10-15 CA CA002424729A patent/CA2424729A1/en not_active Abandoned
- 2001-10-15 AU AU2002232381A patent/AU2002232381B2/en not_active Ceased
- 2001-10-15 MX MXPA03003485A patent/MXPA03003485A/en unknown
- 2001-10-15 EA EA200300474A patent/EA200300474A1/en unknown
- 2001-10-15 BR BR0114689-0A patent/BR0114689A/en not_active Application Discontinuation
- 2001-10-15 HU HU0303563A patent/HUP0303563A2/en unknown
- 2001-10-15 WO PCT/US2001/042735 patent/WO2002032377A2/en not_active Application Discontinuation
- 2001-10-15 AU AU3238102A patent/AU3238102A/en active Pending
- 2001-10-15 IL IL15498401A patent/IL154984A0/en unknown
- 2001-10-15 EP EP01987654A patent/EP1333827A2/en not_active Withdrawn
- 2001-10-15 PL PL01361053A patent/PL361053A1/en not_active Application Discontinuation
- 2001-10-15 SK SK477-2003A patent/SK4772003A3/en unknown
-
2002
- 2002-04-15 PE PE2002000308A patent/PE20021083A1/en not_active Application Discontinuation
-
2003
- 2003-03-26 BG BG107676A patent/BG107676A/en unknown
- 2003-03-27 IS IS6761A patent/IS6761A/en unknown
- 2003-04-15 NO NO20031737A patent/NO20031737L/en unknown
- 2003-04-17 EC EC2003004558A patent/ECSP034558A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03003485A (en) | 2003-07-14 |
| PE20021083A1 (en) | 2002-12-16 |
| WO2002032377A2 (en) | 2002-04-25 |
| WO2002032377A3 (en) | 2002-08-22 |
| BR0114689A (en) | 2003-07-01 |
| PL361053A1 (en) | 2004-09-20 |
| JP2004511502A (en) | 2004-04-15 |
| SK4772003A3 (en) | 2003-08-05 |
| NO20031737D0 (en) | 2003-04-15 |
| EE200300153A (en) | 2003-06-16 |
| ECSP034558A (en) | 2003-06-25 |
| NO20031737L (en) | 2003-06-19 |
| EA200300474A1 (en) | 2003-10-30 |
| IL154984A0 (en) | 2003-10-31 |
| KR20030042020A (en) | 2003-05-27 |
| AU2002232381B2 (en) | 2004-11-18 |
| BG107676A (en) | 2003-11-28 |
| AU3238102A (en) | 2002-04-29 |
| EP1333827A2 (en) | 2003-08-13 |
| CA2424729A1 (en) | 2002-04-25 |
| CN1469743A (en) | 2004-01-21 |
| IS6761A (en) | 2003-03-27 |
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