HUP0204393A2 - Pluraflavinok és származékaik, előállításuk és alkalmazásuk - Google Patents
Pluraflavinok és származékaik, előállításuk és alkalmazásukInfo
- Publication number
- HUP0204393A2 HUP0204393A2 HU0204393A HUP0204393A HUP0204393A2 HU P0204393 A2 HUP0204393 A2 HU P0204393A2 HU 0204393 A HU0204393 A HU 0204393A HU P0204393 A HUP0204393 A HU P0204393A HU P0204393 A2 HUP0204393 A2 HU P0204393A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- carbon atoms
- alkyl
- alkenyl
- atom
- Prior art date
Links
- 229930188574 pluraflavin Natural products 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 241000203809 Actinomycetales Species 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/58—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A találmány (I) általános képletű vegyületekre - a képletben R1jelentése cukorcsoport, R2 jelentése -COOH vagy -CH2-O-(R7)m, ahol R7jelentése cukorcsoport, R3 jelentése epoxid-tartalmú csoport, 1-6szénatomos alkilcsoport vagy 2-6 szénatomos alkenilcsoport, ahol afenti alkil- és alkenilcsoport adott esetben legalább egy OH-csoporttal van szubsztituálva, R5 jelentése hidrogénatom, 1-6szénatomos alkilcsoport, 2-6 szénatomos alkenilcsoport vagy 2-6szénatomos alkinilcsoport, R4, R6, R8 és R10 jelentése egymástólfüggetlenül hidrogénatom, 1-6 szénatomos alkilcsoport, 2-6 szénatomosalkenilcsoport, 2-6 szénatomos alkinilcsoport, -X2H általános képletűcsoport, ahol H közvetlenül az X2 csoport első atomjához kapcsolódik,vagy -X2R12 általános képletű csoport, ahol R12 közvetlenül az X2csoport első atomjához kapcsolódik, vagy adott esetben R4 és R6 együttkettős kötéssel kapcsolódó X2 csoportot jelent, vagy adott esetben R9és R10 együtt kettős kötéssel kapcsolódó X2 csoportot jelent, X2jelentése oxigénatom, NH csoport, -N-(1-6 szénatomos alkil) csoport, -N-(2-6 szénatomos alkenil) csoport, -N-(2-6 szénatomos alkinil)csoport vagy kénatom, R12 jelentése 1-6 szénatomos alkilcsoport, 2-6szénatomos alkenilcsoport, 2-6 szénatomos alkinilcsoport, arilcsoportvagy acilcsoport, és m és n értéke egymástól függetlenül 1 vagy 2 ésfiziológiásan elfogadható sóikra vonatkozik. A fenti vegyületek azActinomycetales species HAG 03959, DSM 12931 mikroorganizmustenyészetéből állíthatók elő fermentálással. Ennek megfelelően atalálmány az előállítási eljárásra, valamint a vegyületekgyógyszerként, például tumorellenes szerként történő alkalmazására isvonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00103540A EP1125944A1 (de) | 2000-02-18 | 2000-02-18 | Pluraflavine und Derivate davon, Verfahren zu ihrer Herstellung und Verwendung derselben |
| PCT/EP2001/001660 WO2001060832A2 (en) | 2000-02-18 | 2001-02-15 | Pluraflavins and derivatives thereof, process for their preparation and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0204393A2 true HUP0204393A2 (hu) | 2003-07-28 |
| HUP0204393A3 HUP0204393A3 (en) | 2007-10-29 |
| HU228332B1 HU228332B1 (en) | 2013-03-28 |
Family
ID=8167898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0204393A HU228332B1 (en) | 2000-02-18 | 2001-02-15 | Pluraflavins and derivatives thereof, process for their preparation and use thereof |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6500936B2 (hu) |
| EP (2) | EP1125944A1 (hu) |
| JP (1) | JP4801307B2 (hu) |
| KR (1) | KR100743380B1 (hu) |
| CN (1) | CN1162441C (hu) |
| AR (1) | AR027436A1 (hu) |
| AT (1) | ATE255120T1 (hu) |
| AU (2) | AU2001242404B2 (hu) |
| BR (1) | BR0108128A (hu) |
| CA (1) | CA2400237C (hu) |
| CZ (1) | CZ303810B6 (hu) |
| DE (1) | DE60101313T2 (hu) |
| DK (1) | DK1259523T3 (hu) |
| EE (1) | EE05137B1 (hu) |
| ES (1) | ES2207609T3 (hu) |
| HK (1) | HK1052709B (hu) |
| HR (1) | HRP20020672B1 (hu) |
| HU (1) | HU228332B1 (hu) |
| IL (2) | IL151216A0 (hu) |
| ME (1) | ME00179B (hu) |
| MX (1) | MXPA02006919A (hu) |
| NO (1) | NO323413B1 (hu) |
| PL (1) | PL204842B1 (hu) |
| PT (1) | PT1259523E (hu) |
| RS (1) | RS49991B (hu) |
| RU (1) | RU2255940C2 (hu) |
| SI (1) | SI1259523T1 (hu) |
| SK (1) | SK286691B6 (hu) |
| TR (1) | TR200302180T4 (hu) |
| WO (1) | WO2001060832A2 (hu) |
| ZA (1) | ZA200206795B (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6989386B2 (en) * | 2002-04-30 | 2006-01-24 | Dana-Farber Cancer Institute | Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same |
| CN101921300B (zh) * | 2009-06-10 | 2014-04-02 | 上海来益生物药物研究开发中心有限责任公司 | 一种异黄酮苷类化合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0819148B1 (hu) * | 1986-07-21 | 1996-02-28 | ||
| AU623923B2 (en) * | 1988-07-22 | 1992-05-28 | Masco Corporation | A small hand-held shower head for domestic sinks connected to a faucet |
| US5001058A (en) * | 1988-09-19 | 1991-03-19 | Bristol-Myers Company | BU-3839T antibiotic |
| PT93070A (pt) * | 1989-02-07 | 1990-08-31 | Abbott Lab | Processo de preparacao de altromicinas e de composicoes farmaceuticas que as contem |
| US5168100A (en) * | 1990-03-16 | 1992-12-01 | Sapporo Breweries Limited | Hp530 compounds and process for preparing the same |
| CA2691487C (en) * | 2007-07-06 | 2012-09-04 | Rite-Hite Holding Corporation | Retractable safety barriers and methods of operating same |
-
2000
- 2000-02-18 EP EP00103540A patent/EP1125944A1/de not_active Withdrawn
-
2001
- 2001-02-15 HU HU0204393A patent/HU228332B1/hu not_active IP Right Cessation
- 2001-02-15 MX MXPA02006919A patent/MXPA02006919A/es active IP Right Grant
- 2001-02-15 RS YUP-576/02A patent/RS49991B/sr unknown
- 2001-02-15 AT AT01915255T patent/ATE255120T1/de active
- 2001-02-15 SK SK1180-2002A patent/SK286691B6/sk not_active IP Right Cessation
- 2001-02-15 RU RU2002124772/04A patent/RU2255940C2/ru not_active IP Right Cessation
- 2001-02-15 BR BR0108128-4A patent/BR0108128A/pt not_active Application Discontinuation
- 2001-02-15 SI SI200130056T patent/SI1259523T1/xx unknown
- 2001-02-15 PL PL358297A patent/PL204842B1/pl unknown
- 2001-02-15 AU AU2001242404A patent/AU2001242404B2/en not_active Ceased
- 2001-02-15 AR ARP010100689A patent/AR027436A1/es not_active Application Discontinuation
- 2001-02-15 PT PT01915255T patent/PT1259523E/pt unknown
- 2001-02-15 DE DE60101313T patent/DE60101313T2/de not_active Expired - Lifetime
- 2001-02-15 TR TR2003/02180T patent/TR200302180T4/xx unknown
- 2001-02-15 CA CA002400237A patent/CA2400237C/en not_active Expired - Fee Related
- 2001-02-15 EP EP01915255A patent/EP1259523B1/en not_active Expired - Lifetime
- 2001-02-15 EE EEP200200438A patent/EE05137B1/xx not_active IP Right Cessation
- 2001-02-15 AU AU4240401A patent/AU4240401A/xx active Pending
- 2001-02-15 WO PCT/EP2001/001660 patent/WO2001060832A2/en active IP Right Grant
- 2001-02-15 ES ES01915255T patent/ES2207609T3/es not_active Expired - Lifetime
- 2001-02-15 CN CNB01805207XA patent/CN1162441C/zh not_active Expired - Fee Related
- 2001-02-15 IL IL15121601A patent/IL151216A0/xx unknown
- 2001-02-15 CZ CZ20022826A patent/CZ303810B6/cs not_active IP Right Cessation
- 2001-02-15 ME MEP-2008-286A patent/ME00179B/me unknown
- 2001-02-15 JP JP2001560216A patent/JP4801307B2/ja not_active Expired - Fee Related
- 2001-02-15 KR KR1020027010629A patent/KR100743380B1/ko not_active IP Right Cessation
- 2001-02-15 DK DK01915255T patent/DK1259523T3/da active
- 2001-02-16 US US09/784,035 patent/US6500936B2/en not_active Expired - Lifetime
-
2002
- 2002-08-12 IL IL151216A patent/IL151216A/en not_active IP Right Cessation
- 2002-08-14 NO NO20023845A patent/NO323413B1/no not_active IP Right Cessation
- 2002-08-14 HR HR20020672A patent/HRP20020672B1/xx not_active IP Right Cessation
- 2002-08-26 ZA ZA200206795A patent/ZA200206795B/en unknown
-
2003
- 2003-07-09 HK HK03104938.4A patent/HK1052709B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |