HUP0202710A2 - Vitronektin receptor antagonisták, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents

Vitronektin receptor antagonisták, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk

Info

Publication number
HUP0202710A2
HUP0202710A2 HU0202710A HUP0202710A HUP0202710A2 HU P0202710 A2 HUP0202710 A2 HU P0202710A2 HU 0202710 A HU0202710 A HU 0202710A HU P0202710 A HUP0202710 A HU P0202710A HU P0202710 A2 HUP0202710 A2 HU P0202710A2
Authority
HU
Hungary
Prior art keywords
vitronectin receptor
compounds
pharmaceutical compositions
compositions containing
receptor antagonists
Prior art date
Application number
HU0202710A
Other languages
English (en)
Inventor
Peter J. Manley
William H. Miller
Irene N. Uzinskas
Original Assignee
Smithkline Beecham Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp. filed Critical Smithkline Beecham Corp.
Publication of HUP0202710A2 publication Critical patent/HUP0202710A2/hu
Publication of HUP0202710A3 publication Critical patent/HUP0202710A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

A találmány gyógyszerészetileg aktív, a vitronektin receptort gátló(I) általános képletű vegyületekre - amelyek képletében R1 jelentéseHet vagy Ar általános képletű csoport; és R2 jelentése képletű csoport- és gyógyászatilag elfogadható sóikra vonatkozik. A találmányszerinti vegyületek felhasználhatók gyulladás, rák és cardiovascularisrendellenességek, például az atherosclerosis és a restenosis, valamintolyan betegségek kezelésére, amelyekben a csontreszorpció szerepetjátszik, amilyen például az osteoporosis. A találmány kiterjed avegyületeket tartalmazó gyógyszerkészítményekre is. Ó
HU0202710A 1999-09-07 2000-09-07 Vitronectin receptor antagonists, pharmaceutical compositions containing them and their use HUP0202710A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15278099P 1999-09-07 1999-09-07
PCT/US2000/024514 WO2001017959A2 (en) 1999-09-07 2000-09-07 Vitronectin receptor antagonists

Publications (2)

Publication Number Publication Date
HUP0202710A2 true HUP0202710A2 (hu) 2002-12-28
HUP0202710A3 HUP0202710A3 (en) 2003-06-30

Family

ID=22544416

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202710A HUP0202710A3 (en) 1999-09-07 2000-09-07 Vitronectin receptor antagonists, pharmaceutical compositions containing them and their use

Country Status (29)

Country Link
EP (1) EP1218005B1 (hu)
JP (1) JP4685307B2 (hu)
KR (1) KR100711170B1 (hu)
CN (1) CN1236767C (hu)
AR (1) AR025589A1 (hu)
AT (1) ATE284870T1 (hu)
AU (1) AU768918B2 (hu)
BR (1) BR0013749A (hu)
CA (1) CA2384671A1 (hu)
CO (1) CO5200845A1 (hu)
CZ (1) CZ2002822A3 (hu)
DE (1) DE60016769T2 (hu)
EG (1) EG24179A (hu)
ES (1) ES2234658T3 (hu)
GC (1) GC0000203A (hu)
HK (1) HK1049110B (hu)
HU (1) HUP0202710A3 (hu)
IL (2) IL148325A0 (hu)
MX (1) MXPA02002455A (hu)
NO (1) NO322109B1 (hu)
NZ (1) NZ517296A (hu)
PE (1) PE20010582A1 (hu)
PL (1) PL200404B1 (hu)
PT (1) PT1218005E (hu)
TR (1) TR200200614T2 (hu)
TW (1) TWI255813B (hu)
UY (1) UY26329A1 (hu)
WO (1) WO2001017959A2 (hu)
ZA (1) ZA200201780B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6531494B1 (en) 2001-08-29 2003-03-11 Pharmacia Corporation Gem-substituted αvβ3 antagonists
US6982263B2 (en) 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
GB0315509D0 (en) 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
US7678810B2 (en) * 2004-03-05 2010-03-16 Taisho Pharmaceutical Co., Ltd Thiazole derivative
EA022046B1 (ru) 2010-07-14 2015-10-30 Новартис Аг Гетероциклические соединения, агонисты рецептора ip
US8937069B2 (en) 2012-01-13 2015-01-20 Novartis Ag Substituted pyrrolo[2,3-B]pyrazine compounds and their use
CN105189500A (zh) 2013-02-13 2015-12-23 诺华股份有限公司 Ip受体激动剂杂环化合物
CN108675954A (zh) * 2018-04-03 2018-10-19 爱斯特（成都）生物制药股份有限公司 2-氨基-3-羟甲基吡啶的一种制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325263A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−アミノ−３−フェニルプロピオン酸誘導体
JPH08325264A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−芳香環置換−３−フェニルプロピオン酸またはアクリル酸誘導体
BR9612378A (pt) * 1995-12-29 1999-07-13 Smithkline Beecham Corp Antagonistas receptores de vitronectina
WO1999011255A1 (fr) * 1997-08-28 1999-03-11 Ono Pharmaceutical Co., Ltd. Regulateurs du recepteur active par les agents de proliferation des peroxysomes
PE122699A1 (es) * 1997-09-19 2000-02-12 Smithkline Beecham Corp Antagonistas de receptores de vitronectina
WO1999045927A1 (en) * 1998-03-10 1999-09-16 Smithkline Beecham Corporation Vitronectin receptor antagonists
WO2000009503A1 (en) * 1998-08-13 2000-02-24 Merck & Co., Inc. Integrin receptor antagonists

Also Published As

Publication number Publication date
EP1218005A2 (en) 2002-07-03
HK1049110A1 (en) 2003-05-02
HUP0202710A3 (en) 2003-06-30
TWI255813B (en) 2006-06-01
AU768918B2 (en) 2004-01-08
GC0000203A (en) 2006-03-29
NO20021113L (no) 2002-05-03
ES2234658T3 (es) 2005-07-01
NO20021113D0 (no) 2002-03-06
DE60016769T2 (de) 2005-11-24
NZ517296A (en) 2003-11-28
IL148325A0 (en) 2002-09-12
UY26329A1 (es) 2001-07-31
WO2001017959A3 (en) 2001-05-10
KR20020027624A (ko) 2002-04-13
ZA200201780B (en) 2003-05-28
JP2003508516A (ja) 2003-03-04
KR100711170B1 (ko) 2007-04-27
MXPA02002455A (es) 2002-07-02
PL354176A1 (en) 2003-12-29
IL148325A (en) 2007-06-03
CN1236767C (zh) 2006-01-18
ATE284870T1 (de) 2005-01-15
JP4685307B2 (ja) 2011-05-18
DE60016769D1 (de) 2005-01-20
WO2001017959A2 (en) 2001-03-15
AR025589A1 (es) 2002-12-04
TR200200614T2 (tr) 2002-07-22
AU7354300A (en) 2001-04-10
CN1377269A (zh) 2002-10-30
CZ2002822A3 (cs) 2002-07-17
PT1218005E (pt) 2005-05-31
EP1218005A4 (en) 2002-10-09
PE20010582A1 (es) 2001-06-23
BR0013749A (pt) 2003-06-10
EP1218005B1 (en) 2004-12-15
NO322109B1 (no) 2006-08-14
PL200404B1 (pl) 2009-01-30
HK1049110B (zh) 2005-07-22
CA2384671A1 (en) 2001-03-15
CO5200845A1 (es) 2002-09-27
EG24179A (en) 2008-09-28

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees