HUP0202437A3 - New process for the preparation of (2s,3as,7as)-1-[(s)-alanile]octahydro-1h-indole-2-carboxy acid derivatives and their use for synthesing perindopril - Google Patents

New process for the preparation of (2s,3as,7as)-1-[(s)-alanile]octahydro-1h-indole-2-carboxy acid derivatives and their use for synthesing perindopril

Info

Publication number: HUP0202437A3
Authority: HU; Hungary
Prior art keywords: alanile; synthesing; perindopril; octahydro; indole
Prior art date: 2001-07-24

Application number

HU0202437A

Other languages

English (en)

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-24

Filing date

2002-07-24

Publication date

2003-05-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8865826&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0202437(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-07-24 Application filed by Servier Lab filed Critical Servier Lab

2002-10-28 Publication of HU0202437D0 publication Critical patent/HU0202437D0/hu

2003-02-28 Publication of HUP0202437A2 publication Critical patent/HUP0202437A2/hu

2003-05-28 Publication of HUP0202437A3 publication Critical patent/HUP0202437A3/hu

2013-11-28 Publication of HU229396B1 publication Critical patent/HU229396B1/hu

Links

239000002253 acid Substances 0.000 title 1
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
229960002582 perindopril Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

HU0202437A 2001-07-24 2002-07-24 Új eljárás (2S,3aS,7aS)-1-[(S)-alanil]oktahidro-1H-indol-2-karbonsav vegyületek elõállítására és ezek alkalmazása perindopril elõállítására HU229396B1 (hu)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0109839A FR2827860B1 (fr)	2001-07-24	2001-07-24	Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Publications (4)

Publication Number	Publication Date
HU0202437D0 HU0202437D0 (hu)	2002-10-28
HUP0202437A2 HUP0202437A2 (hu)	2003-02-28
HUP0202437A3 true HUP0202437A3 (en)	2003-05-28
HU229396B1 HU229396B1 (hu)	2013-11-28

Family

ID=8865826

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0202437A HU229396B1 (hu)	2001-07-24	2002-07-24	Új eljárás (2S,3aS,7aS)-1-[(S)-alanil]oktahidro-1H-indol-2-karbonsav vegyületek elõállítására és ezek alkalmazása perindopril elõállítására

Country Status (25)

Country	Link
US (1)	US7060842B2 (hu)
EP (1)	EP1256590B1 (hu)
JP (1)	JP3868957B2 (hu)
KR (1)	KR100607556B1 (hu)
CN (1)	CN1533398A (hu)
AR (1)	AR035081A1 (hu)
AT (1)	ATE318838T1 (hu)
AU (1)	AU2002334027B8 (hu)
BR (1)	BR0211334A (hu)
CA (1)	CA2455706C (hu)
DE (1)	DE60209458T2 (hu)
DK (1)	DK1256590T3 (hu)
EA (1)	EA005490B1 (hu)
ES (1)	ES2259071T3 (hu)
FR (1)	FR2827860B1 (hu)
HU (1)	HU229396B1 (hu)
MA (1)	MA27130A1 (hu)
MX (1)	MXPA04000443A (hu)
NO (1)	NO328234B1 (hu)
NZ (1)	NZ530427A (hu)
PL (1)	PL212408B1 (hu)
PT (1)	PT1256590E (hu)
SI (1)	SI1256590T1 (hu)
WO (1)	WO2003016336A1 (hu)
ZA (1)	ZA200400246B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1333026T1 (sl)	2002-01-30	2007-10-31	Servier Lab	Postopek priprave perindoprila visoke äśistoäśe in intermediatov uporabnih v sintezi
ES2249691T3 (es) *	2003-02-28	2006-04-01	Les Laboratoires Servier	Procedimiento de sintesis de derivados del acido (2s,3as,7as)-1-(s)-alanil)-octahidro-1h-indol-2-carboxilico y su utilizacion en la sintesis de perindopril.
DE60301930T2 (de) *	2003-02-28	2006-07-27	Les Laboratoires Servier	Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze
EP1603558B1 (en)	2003-02-28	2008-05-21	Les Laboratoires Servier S.A.	Process for preparation of perindopril and salts thereof
ES2250847T3 (es) *	2003-02-28	2006-04-16	Les Laboratoires Servier	Nuevo procedimiento de sintesis del acido (2s,3as,7as)-perhidroindol-2-carboxilico y sus eteres y su aplicacion a la sintesis de perindropil.
DE60300116T2 (de) *	2003-03-12	2005-12-22	Les Laboratoires Servier	Verfahren zur Synthese von (2S,3aS,7aS)-Perhydroindol-2-carbonsäure und seinen Estern, und Verwendung in der Synthese von Perindopril
SI1321471T1 (hu) *	2003-03-12	2005-08-31	Servier Lab
SI1319668T1 (en) *	2003-03-12	2005-02-28	Les Laboratoires Servier	Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril
BRPI0411966A (pt)	2003-06-24	2006-08-29	Servier Lab	formas cristalinas de perindopril erbumina
PT1367063E (pt)	2003-07-31	2006-12-29	Servier Lab	Novo processo de síntese do perindopril e dos seus sais farmacêuticamente aceitáveis
JP4720132B2 (ja) *	2003-10-30	2011-07-13	住友化学株式会社	光学活性なｎ−保護−オクタヒドロ−１ｈ−インドール−２−カルボン酸の製造方法
EP1420030A3 (fr) *	2003-12-10	2004-05-26	Les Laboratoires Servier	Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
GB2413128A (en) *	2004-04-13	2005-10-19	Neopharma Ltd	Process for the preparation of perindopril
ITFI20040174A1 (it) *	2004-08-03	2004-11-03	Protera S R L	Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
KR101329457B1 (ko)	2006-12-19	2013-11-15	에스케이바이오팜 주식회사	옥타하이드로인돌-2-카르복시산의 제조방법
FR3050380B1 (fr)	2016-04-20	2020-07-10	Les Laboratoires Servier	Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2503155A2 (fr) *	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807037B1 (fr) *	2000-03-31	2002-05-10	Adir	NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) *	2000-04-06	2002-07-19	Adir	Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) *	2000-04-11	2002-05-17	Adir	Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

2001
- 2001-07-24 FR FR0109839A patent/FR2827860B1/fr not_active Expired - Fee Related
2002
- 2002-07-23 CA CA2455706A patent/CA2455706C/fr not_active Expired - Fee Related
- 2002-07-23 DE DE60209458T patent/DE60209458T2/de not_active Expired - Lifetime
- 2002-07-23 MX MXPA04000443A patent/MXPA04000443A/es active IP Right Grant
- 2002-07-23 AT AT02291853T patent/ATE318838T1/de active
- 2002-07-23 US US10/484,022 patent/US7060842B2/en not_active Expired - Lifetime
- 2002-07-23 NZ NZ530427A patent/NZ530427A/en not_active IP Right Cessation
- 2002-07-23 KR KR1020047001052A patent/KR100607556B1/ko not_active IP Right Cessation
- 2002-07-23 EP EP02291853A patent/EP1256590B1/fr not_active Expired - Lifetime
- 2002-07-23 AR ARP020102757A patent/AR035081A1/es not_active Application Discontinuation
- 2002-07-23 PT PT02291853T patent/PT1256590E/pt unknown
- 2002-07-23 WO PCT/FR2002/002627 patent/WO2003016336A1/fr active IP Right Grant
- 2002-07-23 EA EA200400110A patent/EA005490B1/ru not_active IP Right Cessation
- 2002-07-23 SI SI200230292T patent/SI1256590T1/sl unknown
- 2002-07-23 JP JP2003521258A patent/JP3868957B2/ja not_active Expired - Fee Related
- 2002-07-23 AU AU2002334027A patent/AU2002334027B8/en not_active Ceased
- 2002-07-23 DK DK02291853T patent/DK1256590T3/da active
- 2002-07-23 ES ES02291853T patent/ES2259071T3/es not_active Expired - Lifetime
- 2002-07-23 BR BR0211334-1A patent/BR0211334A/pt not_active IP Right Cessation
- 2002-07-23 CN CNA028146093A patent/CN1533398A/zh active Pending
- 2002-07-24 HU HU0202437A patent/HU229396B1/hu not_active IP Right Cessation
- 2002-07-24 PL PL355159A patent/PL212408B1/pl unknown
2004
- 2004-01-08 MA MA27474A patent/MA27130A1/fr unknown
- 2004-01-13 NO NO20040151A patent/NO328234B1/no not_active IP Right Cessation
- 2004-01-13 ZA ZA200400246A patent/ZA200400246B/en unknown

Also Published As

Publication number	Publication date
NO20040151L (no)	2004-01-13
MXPA04000443A (es)	2004-03-18
EA005490B1 (ru)	2005-02-24
KR20040023673A (ko)	2004-03-18
CN1533398A (zh)	2004-09-29
FR2827860A1 (fr)	2003-01-31
CA2455706A1 (fr)	2003-02-27
AU2002334027B2 (en)	2006-12-14
FR2827860B1 (fr)	2004-12-10
HUP0202437A2 (hu)	2003-02-28
ES2259071T3 (es)	2006-09-16
AU2002334027B8 (en)	2007-01-25
HU229396B1 (hu)	2013-11-28
NZ530427A (en)	2005-08-26
DE60209458D1 (de)	2006-04-27
DK1256590T3 (da)	2006-06-06
NO328234B1 (no)	2010-01-11
WO2003016336A1 (fr)	2003-02-27
EA200400110A1 (ru)	2004-06-24
KR100607556B1 (ko)	2006-08-02
US7060842B2 (en)	2006-06-13
JP3868957B2 (ja)	2007-01-17
MA27130A1 (fr)	2005-01-03
CA2455706C (fr)	2012-01-24
US20040198988A1 (en)	2004-10-07
ATE318838T1 (de)	2006-03-15
AU2002334027A1 (en)	2003-03-03
HU0202437D0 (hu)	2002-10-28
AR035081A1 (es)	2004-04-14
BR0211334A (pt)	2004-09-28
PL212408B1 (pl)	2012-09-28
PT1256590E (pt)	2006-06-30
EP1256590B1 (fr)	2006-03-01
JP2005500386A (ja)	2005-01-06
EP1256590A1 (fr)	2002-11-13
SI1256590T1 (sl)	2006-06-30
DE60209458T2 (de)	2006-10-12
PL355159A1 (en)	2003-01-13
ZA200400246B (en)	2006-07-26

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Legal Events

Date	Code	Title	Description
2020-04-28	MM4A	Lapse of definitive patent protection due to non-payment of fees