HUP0104000A2 - New use of taxoid derivatives - Google Patents
New use of taxoid derivativesInfo
- Publication number
- HUP0104000A2 HUP0104000A2 HU0104000A HUP0104000A HUP0104000A2 HU P0104000 A2 HUP0104000 A2 HU P0104000A2 HU 0104000 A HU0104000 A HU 0104000A HU P0104000 A HUP0104000 A HU P0104000A HU P0104000 A2 HUP0104000 A2 HU P0104000A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- formula
- optionally substituted
- cycloalkyl
- alkynyl
- Prior art date
Links
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 abstract 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000004465 cycloalkenyloxy group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000036457 multidrug resistance Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A tal lm ny t rgya az ltal nos képletű taxoid-sz rmazékok - ahol Zhidrogénatom vagy egy ltal nos képletű csoport, amelyben R1 adottesetben szubsztitu lt benzoilcsoport vagy tenoil- vagy furoilcsoportvagy egy R2-O-CO- ltal nos képletű csoport, amelyben R2 adott esetbenszubsztitu lt alkil-, alkenil-, alkinil-, cikloalkil-, cikloalkenil-,bicikloalkil-, fenil-, naftilcsoport vagy egy arom s heterogyűrű; R3alkil-, alkenil-, alkinil-, cikloalkilcsoport, adott esetbenszubsztitu lt fenil- vagy naftilcsoport vagy egy arom s heterogyűrű;R4 és R5 egym stól függetlenül adott esetben szubsztitu lt alkoxi-,alkenil-oxi-, alkinil-oxi-, cikloalkoxi- vagy cikloalkenil-oxicsoport- új alkalmaz sa a multidrug-rezisztenci val kapcsolatos P-glikoproteint expressz ló rezisztens sejtvonalak abnorm lis szaporod snak kezelésére. Az alkalmaz s sor n egy (I) ltal nos képletű vegyületvagy gyógy szatilag elfogadható sója szolv tja hat sos mennyiségét adjk be péld ul vastagbélr k kezelésére. ÓThe substance of the invention is the taxoid derivatives of the formula - where Hydrogen atom or a group of the formula in which R1 is optionally substituted benzoyl group or thenoyl or furoyl group or a group of the formula R2-O-CO- in which R2 is given an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl, naphthyl group or an aromatic heteroring; R3 is an alkyl, alkenyl, alkynyl, cycloalkyl group, an optionally substituted phenyl or naphthyl group or an aromatic heteroring; R4 and R5 independently of each other are optionally substituted alkyloxy, alkenyloxy, alkynyloxy, cycloalkyl or cycloalkenyloxy group- a new application for the treatment of abnormal proliferation of P-glycoprotein-expressing resistant cell lines associated with multidrug resistance. In the application line, enter an effective amount of a solution of a compound of the formula (I) or a medicinally acceptable salt thereof, for example for the treatment of the colon. HE
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98115650A EP0982028A1 (en) | 1998-08-20 | 1998-08-20 | New use of taxoid derivatives |
| US12384399P | 1999-03-11 | 1999-03-11 | |
| PCT/EP1999/006292 WO2000010547A2 (en) | 1998-08-20 | 1999-08-18 | New use of taxoid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104000A2 true HUP0104000A2 (en) | 2002-04-29 |
| HUP0104000A3 HUP0104000A3 (en) | 2003-01-28 |
Family
ID=26149552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104000A HUP0104000A3 (en) | 1998-08-20 | 1999-08-18 | New use of taxoid derivatives |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1105119A2 (en) |
| JP (1) | JP2002523364A (en) |
| KR (1) | KR20010079665A (en) |
| CN (1) | CN1313764A (en) |
| AU (1) | AU5742099A (en) |
| BG (1) | BG105273A (en) |
| CA (1) | CA2341191A1 (en) |
| EE (1) | EE200100082A (en) |
| HU (1) | HUP0104000A3 (en) |
| IL (1) | IL141231A0 (en) |
| MX (1) | MXPA01001721A (en) |
| NO (1) | NO20010655D0 (en) |
| SK (1) | SK2352001A3 (en) |
| TR (1) | TR200100575T2 (en) |
| WO (1) | WO2000010547A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2922107B1 (en) * | 2007-10-10 | 2010-02-26 | Aventis Pharma Sa | NEW TAXOID COMPOSITIONS |
| CA2779009A1 (en) | 2009-10-29 | 2011-05-05 | Aventis Pharma S.A. | Novel antitumoral use of cabazitaxel |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2697522B1 (en) * | 1992-10-30 | 1994-11-25 | Rhone Poulenc Rorer Sa | Process for the preparation of taxane derivatives. |
| MA23823A1 (en) * | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | NEW TAXOIDS, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM |
| FR2732968B1 (en) * | 1995-04-14 | 1997-05-16 | Rhone Poulenc Rorer Sa | NOVEL TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1999
- 1999-08-18 JP JP2000565869A patent/JP2002523364A/en active Pending
- 1999-08-18 TR TR2001/00575T patent/TR200100575T2/en unknown
- 1999-08-18 SK SK235-2001A patent/SK2352001A3/en unknown
- 1999-08-18 EE EEP200100082A patent/EE200100082A/en unknown
- 1999-08-18 CN CN99809900A patent/CN1313764A/en active Pending
- 1999-08-18 WO PCT/EP1999/006292 patent/WO2000010547A2/en not_active Application Discontinuation
- 1999-08-18 IL IL14123199A patent/IL141231A0/en unknown
- 1999-08-18 HU HU0104000A patent/HUP0104000A3/en unknown
- 1999-08-18 AU AU57420/99A patent/AU5742099A/en not_active Abandoned
- 1999-08-18 CA CA002341191A patent/CA2341191A1/en not_active Abandoned
- 1999-08-18 MX MXPA01001721A patent/MXPA01001721A/en unknown
- 1999-08-18 EP EP99944532A patent/EP1105119A2/en not_active Withdrawn
- 1999-08-18 KR KR1020017002136A patent/KR20010079665A/en not_active Application Discontinuation
-
2001
- 2001-02-07 NO NO20010655A patent/NO20010655D0/en unknown
- 2001-02-20 BG BG105273A patent/BG105273A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20010655L (en) | 2001-02-07 |
| IL141231A0 (en) | 2002-03-10 |
| SK2352001A3 (en) | 2001-07-10 |
| TR200100575T2 (en) | 2001-07-23 |
| BG105273A (en) | 2001-11-30 |
| MXPA01001721A (en) | 2005-06-03 |
| HUP0104000A3 (en) | 2003-01-28 |
| WO2000010547A2 (en) | 2000-03-02 |
| NO20010655D0 (en) | 2001-02-07 |
| CA2341191A1 (en) | 2000-03-02 |
| KR20010079665A (en) | 2001-08-22 |
| EE200100082A (en) | 2002-06-17 |
| WO2000010547A3 (en) | 2000-06-29 |
| EP1105119A2 (en) | 2001-06-13 |
| CN1313764A (en) | 2001-09-19 |
| AU5742099A (en) | 2000-03-14 |
| JP2002523364A (en) | 2002-07-30 |
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