HUP0101711A2 - Eljárás kémiai hatóanyagok azonosítására és hatóanyagok az 1-dezoxi-D-xilulóz-5-foszfát bioszintézisút gátlására - Google Patents
Eljárás kémiai hatóanyagok azonosítására és hatóanyagok az 1-dezoxi-D-xilulóz-5-foszfát bioszintézisút gátlásáraInfo
- Publication number
- HUP0101711A2 HUP0101711A2 HU0101711A HUP0101711A HUP0101711A2 HU P0101711 A2 HUP0101711 A2 HU P0101711A2 HU 0101711 A HU0101711 A HU 0101711A HU P0101711 A HUP0101711 A HU P0101711A HU P0101711 A2 HUP0101711 A2 HU P0101711A2
- Authority
- HU
- Hungary
- Prior art keywords
- active agents
- xylulose
- desoxy
- inhibiting
- biosynthetic pathway
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000126 substance Substances 0.000 title abstract 3
- AJPADPZSRRUGHI-RFZPGFLSSA-N 1-deoxy-D-xylulose 5-phosphate Chemical compound CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O AJPADPZSRRUGHI-RFZPGFLSSA-N 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 230000006696 biosynthetic metabolic pathway Effects 0.000 title 1
- 244000045947 parasite Species 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002141 anti-parasite Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000037353 metabolic pathway Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
Abstract
A találmány eljárás egy- vagy többsejtű paraziták okoztamegbetegedések kezelésére alkalmas kémiai hatóanyagok megtalálására.Az eljárás során az 1-dezoxi-D-xilulóz-5-foszfát anyagcsereúton résztvevő proteineket vagy azonos hatású származékaikat a paraziták ellenihatására vizsgálni kívánt anyagokkal érintkeztetik, majd a proteineketvagy származékaikat gátló anyagokat kiválasztják. A találmány továbbáaz azonosított hatóanyagokra és paraziták okozta fertőző betegségekkezelésére alkamazható gyógyászati készítmények előállításához valóalkalmazásukra is vonatkozik. Ó
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19816196 | 1998-04-14 | ||
| DE19825585A DE19825585A1 (de) | 1998-04-14 | 1998-06-09 | Verwendung von Aminohydrocarbylphosphonsäurederivaten zur therapeutischen und prophylaktischen Behandlung von Infektionen, die durch Parasiten, Pilze oder Viren hervorgerufen werden |
| DE19828097A DE19828097A1 (de) | 1998-06-24 | 1998-06-24 | Kombinationspräparat von Aminohydrocarbylphosphonsäurederivaten und Hemmern des Fettstoffwechsels |
| DE19831639A DE19831639C1 (de) | 1998-07-15 | 1998-07-15 | Phosphororganische Verbindungen und ihre Verwendung |
| DE19831637A DE19831637A1 (de) | 1998-07-15 | 1998-07-15 | Verwendung von phosphororganischen Verbindungen zur therapeutischen und prophylaktischen Behandlung von Infektionen, die durch Parasiten hervorgerufen werden |
| DE19831638 | 1998-07-15 | ||
| DE19843279 | 1998-09-22 | ||
| PCT/EP1999/002463 WO1999052938A2 (de) | 1998-04-14 | 1999-04-13 | Identifizierung chemischer wirkstoffe zur hemmung des 1-desoxy-d-xylulose-5-phosphat-biosynthesewegs in parasiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0101711A2 true HUP0101711A2 (hu) | 2001-09-28 |
Family
ID=27561757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0101711A HUP0101711A2 (hu) | 1998-04-14 | 1999-04-13 | Eljárás kémiai hatóanyagok azonosítására és hatóanyagok az 1-dezoxi-D-xilulóz-5-foszfát bioszintézisút gátlására |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1071959A2 (hu) |
| JP (1) | JP2002511486A (hu) |
| CN (1) | CN1297532A (hu) |
| AP (1) | AP2000001937A0 (hu) |
| AU (1) | AU753169B2 (hu) |
| CA (1) | CA2328157A1 (hu) |
| HU (1) | HUP0101711A2 (hu) |
| IL (1) | IL138721A0 (hu) |
| MX (1) | MXPA00010069A (hu) |
| OA (1) | OA11500A (hu) |
| PL (1) | PL358989A1 (hu) |
| SK (1) | SK15232000A3 (hu) |
| TR (1) | TR200002972T2 (hu) |
| WO (1) | WO1999052938A2 (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU757440B2 (en) * | 1998-08-05 | 2003-02-20 | Sungene Gmbh And Co. Kgaa | DNA sequence coding for a 1-deoxy-d-xylulose-5-phosphate synthase and the overproduction thereof in plants |
| IL141888A0 (en) * | 1998-09-22 | 2002-03-10 | Jomaa Pharmaka Gmbh | Genes of the 1-deoxy-d-xylulose biosynthetic pathway |
| JP2002532101A (ja) * | 1998-12-14 | 2002-10-02 | バッハー，アーデルバート | テルペノイド類生合成阻害剤のためのスクリーニング |
| GB9901902D0 (en) * | 1999-01-28 | 1999-03-17 | New Royal Holloway & Bedford | Manipulating isoprenoid expression |
| CN1351715A (zh) * | 1999-05-21 | 2002-05-29 | 朱马制药有限公司 | 脱氧－d－木酮糖磷酸生物合成途径的基因在改变类异戊二烯浓度中的应用 |
| AU6280300A (en) | 1999-08-04 | 2001-03-05 | Adelbert Bacher | Isoprenoid biosynthesis |
| DE10021688A1 (de) * | 2000-05-05 | 2001-11-15 | Hassan Jomaa | Gene des 1-Desoxy-D-xylulose-Biosynthesewegs |
| DE10027821A1 (de) * | 2000-06-05 | 2001-12-06 | Adelbert Bacher | Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg |
| DE10201458A1 (de) | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
| CN102860999B (zh) * | 2012-10-12 | 2014-04-09 | 西北大学 | 1-脱氧-d-木酮糖5-磷酸还原异构化酶抑制剂及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19752700A1 (de) * | 1997-11-28 | 1999-06-02 | Hoechst Schering Agrevo Gmbh | 1-Desoxy-D-xylulose-5-phosphat Synthase, Verfahren zur Identifizierung von Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase und Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase |
-
1999
- 1999-04-13 EP EP99920648A patent/EP1071959A2/de not_active Withdrawn
- 1999-04-13 WO PCT/EP1999/002463 patent/WO1999052938A2/de not_active Application Discontinuation
- 1999-04-13 AU AU44816/99A patent/AU753169B2/en not_active Ceased
- 1999-04-13 HU HU0101711A patent/HUP0101711A2/hu unknown
- 1999-04-13 MX MXPA00010069A patent/MXPA00010069A/es unknown
- 1999-04-13 PL PL99358989A patent/PL358989A1/xx not_active Application Discontinuation
- 1999-04-13 SK SK1523-2000A patent/SK15232000A3/sk unknown
- 1999-04-13 JP JP2000543494A patent/JP2002511486A/ja active Pending
- 1999-04-13 CN CN99805023A patent/CN1297532A/zh active Pending
- 1999-04-13 CA CA002328157A patent/CA2328157A1/en not_active Abandoned
- 1999-04-13 AP APAP/P/2000/001937A patent/AP2000001937A0/en unknown
- 1999-04-13 IL IL13872199A patent/IL138721A0/xx unknown
- 1999-04-13 TR TR2000/02972T patent/TR200002972T2/xx unknown
-
2000
- 2000-10-12 OA OA1200000280A patent/OA11500A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK15232000A3 (sk) | 2001-05-10 |
| PL358989A1 (en) | 2004-08-23 |
| OA11500A (en) | 2004-05-14 |
| AU4481699A (en) | 1999-11-01 |
| CN1297532A (zh) | 2001-05-30 |
| WO1999052938A2 (de) | 1999-10-21 |
| CA2328157A1 (en) | 1999-10-21 |
| TR200002972T2 (tr) | 2001-01-22 |
| JP2002511486A (ja) | 2002-04-16 |
| WO1999052938A3 (de) | 1999-12-09 |
| AP2000001937A0 (en) | 2000-12-31 |
| EP1071959A2 (de) | 2001-01-31 |
| IL138721A0 (en) | 2001-10-31 |
| MXPA00010069A (es) | 2002-08-06 |
| AU753169B2 (en) | 2002-10-10 |
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