HUP0100328A2 - Novel triazolo(4,5-d)pyrimidine compounds, and pharmaceutical compositions containing the compounds - Google Patents
Novel triazolo(4,5-d)pyrimidine compounds, and pharmaceutical compositions containing the compoundsInfo
- Publication number
- HUP0100328A2 HUP0100328A2 HU0100328A HUP0100328A HUP0100328A2 HU P0100328 A2 HUP0100328 A2 HU P0100328A2 HU 0100328 A HU0100328 A HU 0100328A HU P0100328 A HUP0100328 A HU P0100328A HU P0100328 A2 HUP0100328 A2 HU P0100328A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- group
- alkyl
- optionally
- carbon atoms
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- -1 substituted Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A találmány (I) általános képletű vegyületekre, gyógyászatilagalkalmazható sóikra és ezek szolvátjaira vonatkozik - a képletben R11-6 szénatomos alkil-, 2-6 szénatomos alkenil-, 2-6 szénatomosalkinil-, 3-8 szénatomos cikloalkil-, aril- vagy tienilcsoportotjelent, amelyek bármelyikéhez adott esetben egy vagy többszubsztituens kapcsolódhat; R2 1-8 szénatomos alkil-, 2-8 szénatomosalkenil- vagy 3-8 szénatomos cikloalkilcsoportot jelent, amelyekbármelyikéhez adott esetben egy vagy több szubsztituens kapcsolódhat;R3 és R4 hidroxilcsoportot jelent; R5 hidrogénatomot vagy 1-6szénatomos alkilcsoportot jelent; és R6 adott esetben szubsztituált 1-6 szénatomos alkilcsoportot, vagy 3-6 szénatomos cikloalkilcsoportot,vagy adott esetben szubsztituált -A-fenil- vagy -A-piridil-csoportotjelent; vagy R5 és R6 a közbezárt nitrogénatommal együtt 5-7 tagútelített, adott esetben alkil-szubsztituált gyűrűt alkothat. Az (I)általános képletű vegyületeket tartalmazó gyógyszerkészítményektrombózis ellenes hatással rendelkezik. ÓThe invention relates to compounds of general formula (I), their medicinally applicable salts and their solvates - in the formula, R11 represents a C-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, aryl or thienyl group, to any of which one or more substituents may optionally be attached; R2 represents a C1-8 alkyl, C2-8 alkenyl or C3-8 cycloalkyl group, to any of which one or more substituents may be attached as appropriate; R3 and R4 represent a hydroxyl group; R5 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; and R6 optionally represents a substituted alkyl group of 1-6 carbon atoms, or a cycloalkyl group of 3-6 carbon atoms, or an optionally substituted -A-phenyl- or -A-pyridyl group; or R5 and R6 together with the nitrogen atom enclosed in between can form a 5-7 membered saturated, optionally alkyl-substituted ring. Pharmaceutical preparations containing compounds of general formula (I) have an anti-thrombosis effect. HE
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9800458A SE9800458D0 (en) | 1998-02-17 | 1998-02-17 | Novel compounds |
| SE9803669A SE9803669D0 (en) | 1998-10-26 | 1998-10-26 | Novel compounds |
| PCT/SE1999/000154 WO1999041254A1 (en) | 1998-02-17 | 1999-02-05 | NOVEL TRIAZOLO(4,5-d)PYRIMIDINE COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100328A2 true HUP0100328A2 (en) | 2001-09-28 |
| HUP0100328A3 HUP0100328A3 (en) | 2003-04-28 |
Family
ID=26663214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100328A HUP0100328A3 (en) | 1998-02-17 | 1999-02-05 | Novel triazolo(4,5-d)pyrimidine compounds, and pharmaceutical compositions containing the compounds |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6369064B1 (en) |
| EP (1) | EP1056749B1 (en) |
| JP (1) | JP2002503663A (en) |
| KR (1) | KR20010078696A (en) |
| CN (1) | CN1291193A (en) |
| AR (1) | AR015515A1 (en) |
| AT (1) | ATE232866T1 (en) |
| AU (1) | AU2650099A (en) |
| BR (1) | BR9907934A (en) |
| CA (1) | CA2316264A1 (en) |
| DE (1) | DE69905451T2 (en) |
| HU (1) | HUP0100328A3 (en) |
| ID (1) | ID27127A (en) |
| IL (1) | IL137812A0 (en) |
| MX (1) | MXPA00007634A (en) |
| NO (1) | NO20004089L (en) |
| NZ (1) | NZ505250A (en) |
| PL (1) | PL342430A1 (en) |
| SK (1) | SK12242000A3 (en) |
| TR (1) | TR200002380T2 (en) |
| WO (1) | WO1999041254A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9702773D0 (en) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| SE9904129D0 (en) * | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
| GB0013488D0 (en) * | 2000-06-02 | 2000-07-26 | Astrazeneca Ab | Chemical compound |
| TWI290549B (en) * | 2000-06-02 | 2007-12-01 | Astrazeneca Ab | Process for the preparation of cyclopropyl carboxylic acid ester and derivatives |
| US7086397B2 (en) * | 2002-02-16 | 2006-08-08 | Graham Lindley Spruiell | Patient usable emergency medical kit |
| GB0219746D0 (en) | 2002-08-23 | 2002-10-02 | Inst Of Ex Botany Ascr | Azapurine derivatives |
| EP1685135B1 (en) * | 2003-10-21 | 2010-05-26 | Inspire Pharmaceuticals, Inc. | TETRAHYDRO-FURO[3,4-d]DIOXOLE COMPOUNDS AND COMPOSITIONS AND METHOD FOR INHIBITING PLATELET AGGREGATION |
| US7749981B2 (en) | 2003-10-21 | 2010-07-06 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound |
| US7335648B2 (en) * | 2003-10-21 | 2008-02-26 | Inspire Pharmaceuticals, Inc. | Non-nucleotide composition and method for inhibiting platelet aggregation |
| US7504497B2 (en) | 2003-10-21 | 2009-03-17 | Inspire Pharmaceuticals, Inc. | Orally bioavailable compounds and methods for inhibiting platelet aggregation |
| US7932376B2 (en) | 2005-05-05 | 2011-04-26 | Inspire Pharmaceuticals, Inc. | Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation |
| WO2007020935A1 (en) * | 2005-08-17 | 2007-02-22 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for pain comprising p2y12 receptor and/or p2y14 receptor blocker |
| WO2008054795A2 (en) * | 2006-10-31 | 2008-05-08 | Janssen Pharmaceutica, N.V. | Triazolopyrimidine derivatives as adp p2y12 receptor antagonists |
| EP2340252B1 (en) * | 2008-09-09 | 2015-11-11 | AstraZeneca AB | A process for preparing [1s- ]1-alpha, 2-alpha, 3-beta (1s*, 2r*) 5-beta] ]-3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino]- 5- (propylthio) -3h-1, 2, 3-triazolo [4, 5-d]pyrimidin-3-yl]-5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates |
| WO2015027431A1 (en) * | 2013-08-29 | 2015-03-05 | Merck Sharp & Dohme Corp. | 2,2-difluorodioxolo a2a receptor antagonists |
| WO2015162630A1 (en) * | 2014-04-25 | 2015-10-29 | Anlon Chemical Research Organization | Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis. |
| DK3433234T3 (en) | 2016-03-22 | 2022-01-03 | Merck Sharp & Dohme | ALLOSTERIC MODULATORS OF NICOTINACETYLCHOLINE RECEPTORS |
| CN111116592A (en) * | 2019-11-27 | 2020-05-08 | 杭州沧海帆医药科技有限公司 | Pyrimidotriazole compounds and medical application thereof |
| CN112876485A (en) * | 2021-01-25 | 2021-06-01 | 郭丽伟 | Compound for treating uterine smooth muscle high-frequency tonic contraction related diseases |
| WO2023091768A1 (en) * | 2021-11-22 | 2023-05-25 | Purdue Research Foundation | Cell-potent bisubstrate inhibitors for nicotinamide n-methyltransferase (nnmt) and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4742064A (en) | 1985-09-10 | 1988-05-03 | Regents Of The University Of Minnesota | Antiviral carbocyclic analogs of xylofuranosylpurines |
| GB8826205D0 (en) | 1988-11-09 | 1988-12-14 | Wellcome Found | Heterocyclic compounds |
| BR9609467A (en) * | 1995-07-11 | 1999-03-02 | Astra Pharma Prod | Compound use of a compound Pharmaceutical composition and processes for preparing a compound and treating plank aggregation disorders |
| EP0946561B1 (en) | 1996-12-20 | 2002-02-13 | AstraZeneca AB | Triazolo(4,5-d)pyrimidinyl derivatives and their use as medicaments |
| SE9702772D0 (en) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| SE9702774D0 (en) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
-
1999
- 1999-02-05 JP JP2000531447A patent/JP2002503663A/en active Pending
- 1999-02-05 US US09/269,330 patent/US6369064B1/en not_active Expired - Fee Related
- 1999-02-05 ID IDW20001348A patent/ID27127A/en unknown
- 1999-02-05 DE DE69905451T patent/DE69905451T2/en not_active Expired - Fee Related
- 1999-02-05 PL PL99342430A patent/PL342430A1/en not_active Application Discontinuation
- 1999-02-05 IL IL13781299A patent/IL137812A0/en unknown
- 1999-02-05 BR BR9907934-8A patent/BR9907934A/en not_active IP Right Cessation
- 1999-02-05 TR TR2000/02380T patent/TR200002380T2/en unknown
- 1999-02-05 MX MXPA00007634A patent/MXPA00007634A/en unknown
- 1999-02-05 SK SK1224-2000A patent/SK12242000A3/en unknown
- 1999-02-05 CN CN99802951A patent/CN1291193A/en active Pending
- 1999-02-05 HU HU0100328A patent/HUP0100328A3/en unknown
- 1999-02-05 KR KR1020007008936A patent/KR20010078696A/en not_active Application Discontinuation
- 1999-02-05 NZ NZ505250A patent/NZ505250A/en unknown
- 1999-02-05 WO PCT/SE1999/000154 patent/WO1999041254A1/en not_active Application Discontinuation
- 1999-02-05 EP EP99906644A patent/EP1056749B1/en not_active Expired - Lifetime
- 1999-02-05 AU AU26500/99A patent/AU2650099A/en not_active Abandoned
- 1999-02-05 AT AT99906644T patent/ATE232866T1/en not_active IP Right Cessation
- 1999-02-05 CA CA002316264A patent/CA2316264A1/en not_active Abandoned
- 1999-02-08 AR ARP990100529A patent/AR015515A1/en unknown
-
2000
- 2000-08-16 NO NO20004089A patent/NO20004089L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ID27127A (en) | 2001-03-01 |
| NO20004089L (en) | 2000-10-16 |
| NO20004089D0 (en) | 2000-08-16 |
| CA2316264A1 (en) | 1999-08-19 |
| EP1056749A1 (en) | 2000-12-06 |
| JP2002503663A (en) | 2002-02-05 |
| BR9907934A (en) | 2000-10-24 |
| SK12242000A3 (en) | 2001-03-12 |
| AU2650099A (en) | 1999-08-30 |
| DE69905451T2 (en) | 2003-11-20 |
| KR20010078696A (en) | 2001-08-21 |
| DE69905451D1 (en) | 2003-03-27 |
| TR200002380T2 (en) | 2001-03-21 |
| NZ505250A (en) | 2002-10-25 |
| EP1056749B1 (en) | 2003-02-19 |
| AR015515A1 (en) | 2001-05-02 |
| HUP0100328A3 (en) | 2003-04-28 |
| PL342430A1 (en) | 2001-06-04 |
| CN1291193A (en) | 2001-04-11 |
| MXPA00007634A (en) | 2003-09-10 |
| ATE232866T1 (en) | 2003-03-15 |
| US6369064B1 (en) | 2002-04-09 |
| WO1999041254A1 (en) | 1999-08-19 |
| IL137812A0 (en) | 2001-10-31 |
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