HUP0003584A2 - Method of increasing bone volume - Google Patents
Method of increasing bone volumeInfo
- Publication number
- HUP0003584A2 HUP0003584A2 HU0003584A HUP0003584A HUP0003584A2 HU P0003584 A2 HUP0003584 A2 HU P0003584A2 HU 0003584 A HU0003584 A HU 0003584A HU P0003584 A HUP0003584 A HU P0003584A HU P0003584 A2 HUP0003584 A2 HU P0003584A2
- Authority
- HU
- Hungary
- Prior art keywords
- bone volume
- patient
- bone
- increasing bone
- agent
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 102000000471 Prostaglandin F receptors Human genes 0.000 abstract 1
- 108050008995 Prostaglandin F receptors Proteins 0.000 abstract 1
- 102000015433 Prostaglandin Receptors Human genes 0.000 abstract 1
- 108010050183 Prostaglandin Receptors Proteins 0.000 abstract 1
- 102000003923 Protein Kinase C Human genes 0.000 abstract 1
- 108090000315 Protein Kinase C Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- WWSWYXNVCBLWNZ-QIZQQNKQSA-N fluprostenol Chemical compound C([C@H](O)\C=C\[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C\C=C/CCCC(O)=O)OC1=CC=CC(C(F)(F)F)=C1 WWSWYXNVCBLWNZ-QIZQQNKQSA-N 0.000 abstract 1
- 229950009951 fluprostenol Drugs 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 208000005368 osteomalacia Diseases 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 102000017953 prostanoid receptors Human genes 0.000 abstract 1
- 108050007059 prostanoid receptors Proteins 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A találmány tárgyát elsősorban a beteg proteinkináz C sejten belülikalciumpályáit aktiváló ágens alkalmazása képezi a betegcsonttérfogatának, trabeculaszámának növelésére, vagycsontrendellenességeinek, így az osteoporosis, osteoarthritis, Paget-betegség, osteomalacia és a csonttörés kezelésére szolgáló gyógyszerelőállítására. Az említett ágens egy nem természetes előfordulású FPagonista, egy olyan prosztaglandin-analóg, így a fluprosztenol, amelyaz egyéb serkentő prosztaglandin receptorokkal, az összes többiprosztanoid receptorokkal szemben legalább 1 : 10 arányban szelektívaz FP receptorra. ÓThe subject of the invention is primarily the use of an agent that activates the intracellular calcium pathways of the patient's protein kinase C to increase the patient's bone volume and trabeculae number, or to produce a drug for the treatment of bone disorders, such as osteoporosis, osteoarthritis, Paget's disease, osteomalacia, and bone fracture. The mentioned agent is a non-naturally occurring FP agonist, a prostaglandin analog, such as fluprostenol, which is selective for the FP receptor in a ratio of at least 1:10 compared to other stimulating prostaglandin receptors and all other prostanoid receptors. HE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5821897P | 1997-09-09 | 1997-09-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0003584A2 true HUP0003584A2 (en) | 2001-02-28 |
| HUP0003584A3 HUP0003584A3 (en) | 2002-12-28 |
Family
ID=22015432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003584A HUP0003584A3 (en) | 1997-09-09 | 1998-09-04 | Method of increasing bone volume |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1035853A1 (en) |
| JP (1) | JP2001515863A (en) |
| CN (1) | CN1269720A (en) |
| AR (1) | AR013478A1 (en) |
| AU (1) | AU9130298A (en) |
| BR (1) | BR9811775A (en) |
| CA (1) | CA2303799A1 (en) |
| CO (1) | CO5070621A1 (en) |
| HU (1) | HUP0003584A3 (en) |
| ID (1) | ID24759A (en) |
| IL (1) | IL134759A0 (en) |
| NO (1) | NO20001172L (en) |
| PE (1) | PE118899A1 (en) |
| PL (1) | PL339297A1 (en) |
| SK (1) | SK3402000A3 (en) |
| WO (1) | WO1999012550A1 (en) |
| ZA (1) | ZA988229B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1159266B1 (en) * | 1999-03-05 | 2004-11-03 | Duke University | C-16 unsaturated fp-selective prostaglandins analogs |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993015767A1 (en) * | 1992-02-05 | 1993-08-19 | Merck & Co., Inc. | Implant therapy for bone growth stimulation |
| HN1996000101A (en) * | 1996-02-28 | 1997-06-26 | Inc Pfizer | COMBINED THERAPY FOR OSTEOPOROSIS |
-
1998
- 1998-09-04 HU HU0003584A patent/HUP0003584A3/en unknown
- 1998-09-04 SK SK340-2000A patent/SK3402000A3/en unknown
- 1998-09-04 PL PL98339297A patent/PL339297A1/en unknown
- 1998-09-04 BR BR9811775-0A patent/BR9811775A/en not_active Application Discontinuation
- 1998-09-04 AU AU91302/98A patent/AU9130298A/en not_active Abandoned
- 1998-09-04 WO PCT/US1998/018337 patent/WO1999012550A1/en not_active Application Discontinuation
- 1998-09-04 CA CA002303799A patent/CA2303799A1/en not_active Abandoned
- 1998-09-04 EP EP98943532A patent/EP1035853A1/en not_active Withdrawn
- 1998-09-04 ID IDW20000638A patent/ID24759A/en unknown
- 1998-09-04 IL IL13475998A patent/IL134759A0/en unknown
- 1998-09-04 JP JP2000510447A patent/JP2001515863A/en not_active Withdrawn
- 1998-09-04 CN CN98808884A patent/CN1269720A/en active Pending
- 1998-09-08 AR ARP980104480A patent/AR013478A1/en not_active Application Discontinuation
- 1998-09-09 CO CO98051809A patent/CO5070621A1/en unknown
- 1998-09-09 PE PE1998000855A patent/PE118899A1/en not_active Application Discontinuation
- 1998-09-09 ZA ZA988229A patent/ZA988229B/en unknown
-
2000
- 2000-03-07 NO NO20001172A patent/NO20001172L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20001172D0 (en) | 2000-03-07 |
| NO20001172L (en) | 2000-05-08 |
| PL339297A1 (en) | 2000-12-04 |
| JP2001515863A (en) | 2001-09-25 |
| AU9130298A (en) | 1999-03-29 |
| HUP0003584A3 (en) | 2002-12-28 |
| ZA988229B (en) | 1999-03-09 |
| WO1999012550A1 (en) | 1999-03-18 |
| PE118899A1 (en) | 2000-02-03 |
| ID24759A (en) | 2000-08-03 |
| EP1035853A1 (en) | 2000-09-20 |
| CA2303799A1 (en) | 1999-03-18 |
| BR9811775A (en) | 2000-08-29 |
| SK3402000A3 (en) | 2000-12-11 |
| AR013478A1 (en) | 2000-12-27 |
| CO5070621A1 (en) | 2001-08-28 |
| CN1269720A (en) | 2000-10-11 |
| IL134759A0 (en) | 2001-04-30 |
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