HUP0003513A2 - Apoptózist indukáló monoklonális antitest - Google Patents

Apoptózist indukáló monoklonális antitest

Info

Publication number
HUP0003513A2
HUP0003513A2 HU0003513A HUP0003513A HUP0003513A2 HU P0003513 A2 HUP0003513 A2 HU P0003513A2 HU 0003513 A HU0003513 A HU 0003513A HU P0003513 A HUP0003513 A HU P0003513A HU P0003513 A2 HUP0003513 A2 HU P0003513A2
Authority
HU
Hungary
Prior art keywords
inducing apoptosis
subject
monoclonal antibodies
monoclonal antibody
antibodies according
Prior art date
Application number
HU0003513A
Other languages
English (en)
Inventor
Naoshi Fukushima
Shinsuke Uno
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of HUP0003513A2 publication Critical patent/HUP0003513A2/hu
Publication of HUP0003513A3 publication Critical patent/HUP0003513A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A találmány tárgyát monoklonális antitestek képezik, amelyek képesekintegrinasszociált fehérjéket (Integrin Associated Proteins, IAP)tartalmazó, sejtmaggal rendelkező vérsejtek apoptózisát indukálni; atalálmány tárgyát képezik továbbá a találmány szerinti monoklonálisantitestek fragmensei, peptidjei és kis molekulatömegű vegyületei; atalálmány tárgyát képezik a találmány szerinti monoklonálisantitesteket termelő hibridómák is. A találmány szerinti antitestekterápiás ágensként alkalmazhatók mieloid leukémia és limfoid leukémiaesetében. Ó
HU0003513A 1997-09-11 1998-09-11 Monoclonal antibody inducing apoptosis HUP0003513A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26485397 1997-09-11

Publications (2)

Publication Number Publication Date
HUP0003513A2 true HUP0003513A2 (hu) 2001-02-28
HUP0003513A3 HUP0003513A3 (en) 2004-05-28

Family

ID=17409137

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003513A HUP0003513A3 (en) 1997-09-11 1998-09-11 Monoclonal antibody inducing apoptosis

Country Status (14)

Country Link
US (1) US20030157100A1 (hu)
EP (1) EP1035132B1 (hu)
KR (2) KR20010023866A (hu)
CN (1) CN1198845C (hu)
AT (1) ATE395362T1 (hu)
AU (1) AU740225B2 (hu)
CA (1) CA2303072A1 (hu)
DE (1) DE69839492D1 (hu)
HU (1) HUP0003513A3 (hu)
NO (1) NO20001238L (hu)
PL (1) PL339265A1 (hu)
RU (1) RU2212413C2 (hu)
SK (1) SK3232000A3 (hu)
WO (1) WO1999012973A1 (hu)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0721015B1 (en) * 1993-09-03 2004-10-27 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody that induces apoptosis
US7531643B2 (en) * 1997-09-11 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
AU2940900A (en) * 1999-03-10 2000-09-28 Chugai Seiyaku Kabushiki Kaisha Single-stranded fv inducing apoptosis
US7696325B2 (en) 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis
TWI241345B (en) * 2000-03-10 2005-10-11 Chugai Pharmaceutical Co Ltd Apoptosis inducing polypeptide
US20040058393A1 (en) * 2000-04-17 2004-03-25 Naoshi Fukishima Agonist antibodies
AU2001246934A1 (en) * 2000-04-17 2001-10-30 Chugai Seiyaku Kabushiki Kaisha Agonist antibodies
KR100870123B1 (ko) * 2000-10-20 2008-11-25 츄가이 세이야꾸 가부시키가이샤 저분자화 아고니스트 항체
ATE391174T1 (de) 2000-10-20 2008-04-15 Chugai Pharmaceutical Co Ltd Modifizierter tpo-agonisten antikörper
CA2424371A1 (en) * 2000-10-20 2003-04-01 Chugai Seiyaku Kabushiki Kaisha Agonistic monoclonal antibody fragments
EP1327680B1 (en) * 2000-10-20 2008-04-02 Chugai Seiyaku Kabushiki Kaisha Modified tpo agonist antibody
EP2075256A2 (en) 2002-01-14 2009-07-01 William Herman Multispecific binding molecules
AU2003271175A1 (en) 2002-10-11 2004-05-04 Masahiro Abe Cell death-inducing agent
JP2004279086A (ja) 2003-03-13 2004-10-07 Konica Minolta Holdings Inc 放射線画像変換パネル及び放射線画像変換パネルの製造方法
JPWO2004087763A1 (ja) * 2003-03-31 2006-07-27 中外製薬株式会社 Ｃｄ２２に対する改変抗体およびその利用
US8613922B2 (en) 2003-04-24 2013-12-24 The University Of North Carolina At Chapel Hill Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP)
JP4637749B2 (ja) * 2003-11-11 2011-02-23 中外製薬株式会社 ヒト化抗ｃｄ４７抗体
US20070280951A1 (en) * 2003-12-12 2007-12-06 Naoki Kimura Cell Death Inducing Agents
TW200530269A (en) 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Anti-Mpl antibodies
US20070281327A1 (en) * 2003-12-12 2007-12-06 Kiyotaka Nakano Methods of Screening for Modified Antibodies With Agonistic Activities
TW200530266A (en) * 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Method of reinforcing antibody activity
EP1870458B1 (en) 2005-03-31 2018-05-09 Chugai Seiyaku Kabushiki Kaisha sc(Fv)2 STRUCTURAL ISOMERS
WO2006123724A1 (ja) * 2005-05-18 2006-11-23 The University Of Tokushima 抗hla抗体を利用した新規医薬品
CN101262885B (zh) 2005-06-10 2015-04-01 中外制药株式会社 含有sc(Fv)2的药物组合物
EP1908482B1 (en) 2005-06-10 2017-09-06 Chugai Seiyaku Kabushiki Kaisha Stabilizer for protein preparation comprising meglumine and use thereof
WO2007033221A2 (en) * 2005-09-13 2007-03-22 The General Hospital Corporation Methods and compositions for inhibition of immune responses
PE20081004A1 (es) * 2006-07-13 2008-09-18 Chugai Pharmaceutical Co Ltd Agentes inductores de muerte celular
CL2008000719A1 (es) * 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
CA3170329A1 (en) * 2008-01-15 2009-07-23 Siddhartha Jaiswal Methods for manilpulating phagocytosis mediated by cd47
AU2009205706B2 (en) 2008-01-15 2015-03-19 The Board Of Trustees Of The Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
AU2009279676C1 (en) 2008-08-07 2015-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Radioprotectants targeting thrombospondin-1 and CD47
PL2812443T3 (pl) * 2012-02-06 2020-01-31 Inhibrx, Inc. Przeciwciała CD47 i sposoby ich zastosowania
US9221908B2 (en) 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
SG11201504469XA (en) 2012-12-12 2015-07-30 Vasculox Inc Therapeutic cd47 antibodies
CN116425875A (zh) 2015-09-18 2023-07-14 安驰肿瘤公司 治疗性cd47抗体
AU2017295704B2 (en) 2016-07-13 2023-07-13 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
WO2018075960A1 (en) 2016-10-21 2018-04-26 Tioma Therapeutics, Inc. Therapeutic cd47 antibodies
WO2019108733A2 (en) 2017-12-01 2019-06-06 Seattle Genetics, Inc. Cd47 antibodies and uses thereof for treating cancer
CN110066336B (zh) * 2019-05-12 2021-11-09 杭州科兴生物科技有限公司 抗cd47单克隆抗体、片段及其医药用途
CA3234825A1 (en) 2021-10-28 2023-05-04 Lyell Immunopharma, Inc. Methods of generating cells
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2150262C (en) * 1992-12-04 2008-07-08 Kaspar-Philipp Holliger Multivalent and multispecific binding proteins, their manufacture and use
EP0721015B1 (en) * 1993-09-03 2004-10-27 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody that induces apoptosis
US6719972B1 (en) * 1994-06-03 2004-04-13 Repligen Corporation Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies
US5885574A (en) * 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
AU2232597A (en) * 1996-03-06 1997-09-22 Chugai Seiyaku Kabushiki Kaisha Method of screening apoptosis inducing substances
US7531643B2 (en) * 1997-09-11 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
US7696325B2 (en) * 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis

Also Published As

Publication number Publication date
US20030157100A1 (en) 2003-08-21
DE69839492D1 (de) 2008-06-26
KR20010023866A (ko) 2001-03-26
EP1035132A1 (en) 2000-09-13
CN1276798A (zh) 2000-12-13
NO20001238L (no) 2000-05-11
KR20040106585A (ko) 2004-12-17
SK3232000A3 (en) 2000-09-12
RU2212413C2 (ru) 2003-09-20
EP1035132B1 (en) 2008-05-14
EP1035132A4 (en) 2005-02-09
CN1198845C (zh) 2005-04-27
WO1999012973A1 (fr) 1999-03-18
AU740225B2 (en) 2001-11-01
NO20001238D0 (no) 2000-03-09
AU9002898A (en) 1999-03-29
ATE395362T1 (de) 2008-05-15
CA2303072A1 (en) 1999-03-18
HUP0003513A3 (en) 2004-05-28
PL339265A1 (en) 2000-12-04

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees