HUP0002668A2 - Treatment of diabetes with thiazolidinedione and metformin - Google Patents
Treatment of diabetes with thiazolidinedione and metforminInfo
- Publication number
- HUP0002668A2 HUP0002668A2 HU0002668A HUP0002668A HUP0002668A2 HU P0002668 A2 HUP0002668 A2 HU P0002668A2 HU 0002668 A HU0002668 A HU 0002668A HU P0002668 A HUP0002668 A HU P0002668A HU P0002668 A2 HUP0002668 A2 HU P0002668A2
- Authority
- HU
- Hungary
- Prior art keywords
- diabetes
- thiazolidinedione
- metformin
- treatment
- biguanidine
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 title 1
- 229940123464 Thiazolidinedione Drugs 0.000 title 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title 1
- 229960003105 metformin Drugs 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- ZILVNHNSYBNLSZ-UHFFFAOYSA-N 2-(diaminomethylideneamino)guanidine Chemical compound NC(N)=NNC(N)=N ZILVNHNSYBNLSZ-UHFFFAOYSA-N 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000002058 anti-hyperglycaemic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 231100000489 sensitizer Toxicity 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Diabetes mellitus and conditions associated with it, in a mammal, is treated by administration of an insulin sensitiser and a biguanidine antihyperglycaemic agent. A pharmaceutical composition comprises the two compounds and a suitable carrier.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9712857.3A GB9712857D0 (en) | 1997-06-18 | 1997-06-18 | Novel method of treatment |
| GBGB9806706.9A GB9806706D0 (en) | 1998-03-27 | 1998-03-27 | Novel method |
| PCT/EP1998/003690 WO1998057634A1 (en) | 1997-06-18 | 1998-06-15 | Treatment of diabetes with thiazolidinedione and metformin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0002668A2 true HUP0002668A2 (en) | 2000-12-28 |
| HUP0002668A3 HUP0002668A3 (en) | 2001-12-28 |
| HU226960B1 HU226960B1 (en) | 2010-03-29 |
Family
ID=10829472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002668A HU226960B1 (en) | 1997-06-18 | 1998-06-15 | Combination of a dioxothiazolidine and metformin, and pharmaceutical compositions containing the same for the treatment of diabetes |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB9806706D0 (en) |
| HU (1) | HU226960B1 (en) |
-
1998
- 1998-03-27 GB GBGB9806706.9A patent/GB9806706D0/en not_active Ceased
- 1998-06-15 HU HU0002668A patent/HU226960B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9806706D0 (en) | 1998-07-01 |
| HU226960B1 (en) | 2010-03-29 |
| HUP0002668A3 (en) | 2001-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |