HUP0001391A3 - 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands - Google Patents

1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands

Info

Publication number
HUP0001391A3
HUP0001391A3 HU0001391A HUP0001391A HUP0001391A3 HU P0001391 A3 HUP0001391 A3 HU P0001391A3 HU 0001391 A HU0001391 A HU 0001391A HU P0001391 A HUP0001391 A HU P0001391A HU P0001391 A3 HUP0001391 A3 HU P0001391A3
Authority
HU
Hungary
Prior art keywords
piperazines
isoquinolin
phenylmethyl
dopamine receptor
receptor subtype
Prior art date
Application number
HU0001391A
Other languages
Hungarian (hu)
Original Assignee
Neurogen Corp Branford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp Branford filed Critical Neurogen Corp Branford
Publication of HUP0001391A2 publication Critical patent/HUP0001391A2/en
Publication of HUP0001391A3 publication Critical patent/HUP0001391A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU0001391A 1997-03-04 1998-03-03 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands HUP0001391A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81072997A 1997-03-04 1997-03-04
PCT/US1998/004051 WO1998039301A1 (en) 1997-03-04 1998-03-03 1-(isoquinolin-1-yl)-4-(1-phenylmethyl)piperazines; dopamine receptor subtype specific ligands

Publications (2)

Publication Number Publication Date
HUP0001391A2 HUP0001391A2 (en) 2000-10-28
HUP0001391A3 true HUP0001391A3 (en) 2001-12-28

Family

ID=25204554

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001391A HUP0001391A3 (en) 1997-03-04 1998-03-03 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands

Country Status (9)

Country Link
EP (1) EP0970054A1 (en)
JP (1) JP2001512491A (en)
KR (1) KR20000075918A (en)
AU (1) AU6678598A (en)
CA (1) CA2283256A1 (en)
HU (1) HUP0001391A3 (en)
IL (1) IL131427A0 (en)
NZ (1) NZ337183A (en)
WO (1) WO1998039301A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008352A (en) * 1997-04-03 1999-12-28 Neurogen Corporation 1-(isoquinolin-1-yl)-4-(1-phenylmethyl) piperazines; dopamine receptor subtype specific ligands
WO1999021850A1 (en) * 1997-10-24 1999-05-06 Neurogen Corporation 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines being dopamine d4 receptor subtype ligands
US6040448A (en) 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
JP4596792B2 (en) * 2004-02-24 2010-12-15 あすか製薬株式会社 Drugs having both 5-HT1A agonistic action and 5-HT3 antagonistic action
US7887784B2 (en) 2007-03-21 2011-02-15 University Of Montana 1-[(2′-substituted)-piperazin-1′ -yl]-isoquinolines as norepinephrine transporter inhibitor therapeutics and positron emission tomography imaging agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3423003A1 (en) * 1984-06-22 1986-01-02 Beiersdorf Ag, 2000 Hamburg BENZO (C) (1,8) NAPHTHYRIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF, AND PREPARATIONS CONTAINING THESE COMPOUNDS
JPS63227570A (en) * 1987-03-13 1988-09-21 Ss Pharmaceut Co Ltd Isoquinoline derivative
MX9201991A (en) * 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited DERIVATIVES OF PIPERAZINE AND PROCEDURE FOR ITS PREPARATION.

Also Published As

Publication number Publication date
NZ337183A (en) 2001-05-25
KR20000075918A (en) 2000-12-26
EP0970054A1 (en) 2000-01-12
WO1998039301A1 (en) 1998-09-11
AU6678598A (en) 1998-09-22
CA2283256A1 (en) 1998-09-11
IL131427A0 (en) 2001-01-28
JP2001512491A (en) 2001-08-21
HUP0001391A2 (en) 2000-10-28

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