HUP0001311A2 - 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists and pharmaceutical compositions containing them - Google Patents

5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists and pharmaceutical compositions containing them

Info

Publication number
HUP0001311A2
HUP0001311A2 HU0001311A HUP0001311A HUP0001311A2 HU P0001311 A2 HUP0001311 A2 HU P0001311A2 HU 0001311 A HU0001311 A HU 0001311A HU P0001311 A HUP0001311 A HU P0001311A HU P0001311 A2 HUP0001311 A2 HU P0001311A2
Authority
HU
Hungary
Prior art keywords
group
dihydroquinoxaline
aminoalkoxy
diones
pharmaceutical compositions
Prior art date
Application number
HU0001311A
Other languages
Hungarian (hu)
Inventor
Richard Eric Mewshaw
James Albert Nelson
Uresh Shantilal Shah
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of HUP0001311A2 publication Critical patent/HUP0001311A2/en
Publication of HUP0001311A3 publication Critical patent/HUP0001311A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A találmány szerinti vegyületek (I) általános képletében R1 és R2jelentése egymástól függetlenül hidrogénatom, egyenes vagy elágazószénláncú, legfeljebb 10 szénatomos alkilcsoport vagy -(CH2)mAráltalános képletű csoport, ahol Ar jelentése fenilcsoport,naftilcsoport vagy tienilcsoport, amelyek adott esetben egy vagy kettő1-6 szénatomos alkilcsoporttal, halogénatommal, 1-6 szénatomosalkoxicsoporttal és/vagy trifluor-metil-csoporttal szubsztituálvalehetnek, vagy NR1R2 jelentése 1, 2, 3, 4-tetrahidrokinolin-1-il-csoport vagy 1, 2, 3, 4-tetrahidroizokinolin-2-il-csoport, m értéke 1-5, n értéke 1 vagy 2, Y jelentése hidrogénatom, halogénatom, 1-6szénatomos alkilcsoport vagy 1-6 szénatomos alkoxicsoport. A találmánykiterjed a fenti vegyületeket tartalmazó gyógyszerkészítményekre,amelyek antipszichotikus szerként és a Parkinson-kór kezelésérealkalmazhatók. ÓIn the general formula (I) of the compounds according to the invention, R1 and R2 are independently a hydrogen atom, a straight or branched alkyl group with up to 10 carbon atoms or a group with the general formula -(CH2)mAr, where Ar is a phenyl group, a naphthyl group or a thienyl group, which may be one or two 1-6 may be substituted with a carbon alkyl group, a halogen atom, a 1-6 carbon alkoxy group and/or a trifluoromethyl group, or NR1R2 is 1,2,3,4-tetrahydroquinolin-1-yl or 1,2,3,4-tetrahydroisoquinolin-2- il-group, m is 1-5, n is 1 or 2, Y is a hydrogen atom, a halogen atom, a C1-C6 alkyl group or a C1-6 C-alkoxy group. The invention extends to pharmaceutical preparations containing the above compounds, which can be used as antipsychotic agents and for the treatment of Parkinson's disease. HE

HU0001311A 1997-02-18 1998-01-13 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists and pharmaceutical compositions containing them HUP0001311A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80132497A 1997-02-18 1997-02-18
PCT/US1998/001170 WO1998035948A1 (en) 1997-02-18 1998-01-13 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists

Publications (2)

Publication Number Publication Date
HUP0001311A2 true HUP0001311A2 (en) 2001-05-28
HUP0001311A3 HUP0001311A3 (en) 2001-07-30

Family

ID=25180799

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001311A HUP0001311A3 (en) 1997-02-18 1998-01-13 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists and pharmaceutical compositions containing them

Country Status (14)

Country Link
EP (1) EP0963372A1 (en)
JP (1) JP2001511805A (en)
KR (1) KR20000071162A (en)
CN (1) CN1248249A (en)
AR (1) AR011669A1 (en)
AU (1) AU722616B2 (en)
BR (1) BR9807230A (en)
CA (1) CA2278757A1 (en)
HU (1) HUP0001311A3 (en)
IL (1) IL131160A0 (en)
NZ (1) NZ336971A (en)
TW (1) TW434230B (en)
WO (1) WO1998035948A1 (en)
ZA (1) ZA981306B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2285786B1 (en) 2008-06-16 2013-10-09 Merck Patent GmbH Quinoxalinedione derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO179551C (en) * 1987-11-10 1996-10-30 Novo Nordisk As Analogous Process for Preparing Therapeutically Effective Quinoxaline Compounds
DK715888D0 (en) * 1988-12-22 1988-12-22 Ferrosan As QUINOXAL COMPOUNDS, THEIR PREPARATION AND USE
US4975430A (en) * 1989-06-16 1990-12-04 The State Of Oregon Acting By And Through The State Board Of Education On Behalf Of The Oregon Health Sciences University CNQX and its analogs as therapeutics for degenerative neural diseases
PT99864B (en) * 1990-12-21 1999-06-30 Schering Ag METHOD FOR PREPARING NEW PHARMACEUTICAL COMPOSITIONS CONTAINING QUISQUALATE RECEPTOR ANTAGONISTS
US5159083A (en) * 1990-12-28 1992-10-27 Neurogen Corporation Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
WO1994000124A1 (en) * 1992-06-22 1994-01-06 Eckard Weber Glycine receptor antagonists and the use thereof
GB9419318D0 (en) * 1994-09-24 1994-11-09 Pfizer Ltd Therapeutic agents
PT707007E (en) * 1994-10-14 2002-06-28 Merck Patent Gmbh AMINO DERIVATIVES (TIO) ETER AS ACTIVE AGENTS IN THE CNS
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists

Also Published As

Publication number Publication date
CN1248249A (en) 2000-03-22
WO1998035948A1 (en) 1998-08-20
AR011669A1 (en) 2000-08-30
AU6035098A (en) 1998-09-08
HUP0001311A3 (en) 2001-07-30
ZA981306B (en) 1999-08-17
BR9807230A (en) 2000-04-25
TW434230B (en) 2001-05-16
CA2278757A1 (en) 1998-08-20
NZ336971A (en) 2000-10-27
AU722616B2 (en) 2000-08-10
KR20000071162A (en) 2000-11-25
IL131160A0 (en) 2001-01-28
EP0963372A1 (en) 1999-12-15
JP2001511805A (en) 2001-08-14

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